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Wiley电子期刊(1)
NATURE电子期刊(1)
ACS电子期刊(9)
SpringerLink电子期刊(3)
Elsevier电子期刊(20)
在“
Elsevier电子期刊
”中,
命中:
20
条,耗时:0.0129934 秒
在所有数据库中总计命中:
34
条
1.
Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as
G9a
inhibitor
through a combination of shape-based virtual screening and structure-based molecular modification
作者:
Wei-Lin Chen
a
;
Zhi-Hui Wang
a
;
Tao-Tao Feng
a
;
Dong-Dong Li
a
;
Chu-Hui Wang
a
;
Xiao-Li Xu
a
;
b
;
Xiao-Jin Zhang
a
;
b
;
c
;
Qi-Dong You
a
;
b
;
youqidong@gmail.com" class="auth_mail" title="E-mail the corresponding author
;
Xiao-Ke Guo
a
;
b
;
kexin95@126.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Histone methyltransferases
;
G9a
inhibitor
;
Virtual screening
;
Structure&ndash
;
activity relationship
;
Anti-cancer
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
2.
Discovery of novel small molecule
inhibitor
s of lysine methyltransferase
G9a
and their mechanism in leukemia cell lines
作者:
Shukkoor M. Kondengaden
a
;
1
;
Liu-fei Luo
b
;
1
;
Kenneth Huang
a
;
Mengyuan Zhu
a
;
Lanlan Zang
a
;
c
;
Eudoxie Bataba
a
;
Runling Wang
c
;
Cheng Luo
d
;
Binghe Wang
a
;
Keqin Kathy Li
a
;
b
;
kli10@gsu.edu" class="auth_mail" title="E-mail the corresponding author
;
Peng George Wang
a
;
pwang11@gsu.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Lysine methyltransferase
;
G9a
inhibitor
;
Leukemia
;
MALDI-TOF assay
刊名:European Journal of Medicinal Chemistry
出版年:2016
3.
Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (
G9a
) and reduced FGF21 gene expression in Sprague-Dawley rats fed prenatal low protein and postnatal high-fat diets
作者:
Kate J. Claycombe
;
kate.claycombe@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author
;
Emilie E. Vomhof-DeKrey
;
Rolando Garcia
;
William Thomas Johnson
;
Eric Uthus
;
James N. Roemmich
关键词:
Beige adipocyte
;
FGF21
;
G9a
;
Mitochondrial respiration
;
Prenatal low-protein diet
;
Postnatal high-fat diet
;
Subcutaneous adipose tissue
刊名:Journal of Nutritional Biochemistry
出版年:2016
4.
Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase
G9a
作者:
Xi Zhang
a
;
Jianguo Wu
a
;
Jonathan Choiniere
a
;
Zhihong Yang
a
;
b
;
Yi Huang
a
;
c
;
Jason Bennett
a
;
Li Wang
a
;
b
;
c
;
d
;
li.wang@uconn.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
PDK4
;
Arsenic
;
H3K9 methylation
;
G9a
;
BRD4770
刊名:Toxicology and Applied Pharmacology
出版年:2016
5.
G9a
inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status
作者:
Pallavi Agarwal
a
;
Stephen P. Jackson
a
;
b
;
s.jackson@gurdon.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
关键词:
Cancer epigenetics
;
Chemical probes
;
UNC0638
;
Chemotherapeutics
;
Non-homologous end joining
刊名:Cancer Letters
出版年:2016
6.
H3S10 phosphorylation-mediated transcriptional regulation by Aurora kinase A
作者:
Se-Ryeon Kim
;
Kee-Beom Kim
;
Yun-Cheol Chae
;
Jin Woo Park
;
Sang-Beom Seo
;
sangbs@cau.ac.kr" class="auth_mail" title="E-mail the corresponding author
关键词:
Aurora kinase A
;
H3S10 phosphorylation
;
Transcription
;
G9a
;
Leukemia cell differentiation
刊名:Biochemical and Biophysical Research Communications
出版年:2016
7.
Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase
G9a
inhibitor
s: Reducing cytotoxicity by structural simplification
作者:
Shinya Fujishiro
a
;
Kosuke Dodo
a
;
b
;
Eriko Iwasa
a
;
b
;
Yuou Teng
a
;
b
;
&dagger
;
;
Yoshihiro Sohtome
a
;
Yoshitaka Hamashima
a
;
c
;
Akihiro Ito
a
;
Minoru Yoshida
a
;
Mikiko Sodeoka
a
;
b
;
sodeoka@riken.jp
关键词:
Methyltransferase
inhibitor
;
Protein methylation
;
Epigenetics
;
Epidithiodiketopiperazines
;
Chaetocin
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2013
8.
Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their
inhibitor
s
作者:
Hongfang Chi
;
Yasushi Takemoto
;
Tienabe K. Nsiama
;
Tamaki Kato
;
Norikazu Nishino
;
Akihiro Ito
;
Minoru Yoshida
关键词:
AcOH
;
acetic acid
;
Ac2O
;
acetic anhydride
;
AcOEt
;
ethyl acetate
;
AMC
;
7-amino-4-methylcoumarin
;
DCM
;
dichloromethane
;
DCC
;
dicyclohexylcarbodiimide
;
DIEA
;
N
;
N-diisopropylethylamine
;
DMF
;
N
;
N-dimethylformamide
;
Fmoc
;
fluorenylmethyloxycarbonyl
;
HOBt·
;
H2O
;
1-hydroxybenzotriazole hydrate
;
HBTU
;
O-(benzotriazol-1-yl)-N
N ;
N&prime
;
N&prime
;
-tetramethyluronium hexafluorophosphate
;
MCA
;
4-methylcoumaryl-7-amide
;
HPLC
;
high performance liquid chromategraphy
;
HRMS (FAB)
;
high resolution fast atom bo
刊名:Bioorganic and Medicinal Chemistry
出版年:15 February, 2014
9.
Using 鈥榖iased-privileged鈥?scaffolds to identify lysine methyltransferase
inhibitor
s
作者:
Sudhir Kashyap
a
;
b
;
skashyap@iict.res.in" class="auth_mail
;
Joel Sandler
a
;
Ulf Peters
a
;
Eduardo J. Martinez
a
;
Tarun M. Kapoor
a
;
kapoor@rockefeller.edu" class="auth_mail
关键词:
XPJOGIGKCTXMJB-UHFFFAOYSA-N
;
IVEVDWPTYKHHAW-UHFFFAOYSA-N
;
FMEFYYNWPMLLSQ-UHFFFAOYSA-N
;
ZAGVMEFISXIDTO-UHFFFAOYSA-N
;
SHHHJVSEDBVTGU-UHFFFAOYSA-N
;
QKZXPNBIWYTRTN-UHFFFAOYSA-N
;
USUVSCPICQILNG-UHFFFAOYSA-N
;
MTABNHIDEZACNF-UHFFFAOYSA-N
;
HJADUZUHNRQUKM-UHFFFAOYSA-N
;
IKHVAXXUCNOOEX-UHFFFAOYSA-N
;
OONFZBRZWOTLPV-UHFFFAOYSA-N
;
AKAGQDKIIOVNKF-UHFFFAOYSA-N
;
MZXCPWOMNDHPTO-UHFFFAOYSA-N
刊名:Bioorganic and Medicinal Chemistry
出版年:1 April, 2014
10.
Detecting S-adenosyl-l-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay
作者:
Ying Lin
a
;
1
;
Hong Fan
a
;
1
;
Mathias Frederiksen
b
;
Kehao Zhao
a
;
Lei Jiang
a
;
Zhaofu Wang
a
;
Shaolian Zhou
a
;
Weihui Guo
a
;
Jun Gao
a
;
Shu Li
c
;
Edmund Harrington
c
;
Peter Meier
b
;
Clemens Scheufler
b
;
Yao-Chang Xu
a
;
Peter Atadja
a
;
Chris Lu
a
;
En Li
a
;
X. Justin Gu
a
;
justin.gu@novartis.com
关键词:
HMT
;
Uncompetitive
inhibitor
;
G9a
;
BIX-01294
;
SAM
;
Sinefungin
;
Conformational change
;
SET domain
;
CJP702
刊名:Analytical Biochemistry
出版年:2012
1
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