搜索页_+GI50+values

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

外文资源

Elsevier电子期刊(16)

在“Elsevier电子期刊”中，命中：16条，耗时：0.0669936 秒

在所有数据库中总计命中：39条

1.Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines

作者：Nitin P. Lad^a ; ^b ; Sarang Kulkarni^b ; Rajiv Sharma^b ; Malcolm Mascarenhas^b ; Mahesh R. Kulkarni^a ; ^b ; Shivaji S. Pandit^a ; ^{akankshapandit2002@yahoo.com}

关键词：Piperlongumine (PL) derived cyclic sulfonamide (sultams) ; Ring closing metathesis ; Anticancer ; GI50 values

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Novel benzothiazine-piperazine derivatives by peptide-coupling as potential anti-proliferative agents

作者：Ramineni Venkatesh^a ; Suresh Kasaboina^a ; Deepthi Bidayat^a ; U Nikhil Kumar^a ; Nishant Jain^b ; Saritha Jostna Tangeda^d ; Rajashaker Bantu^a ; Sridhara Janardhan^c ; ; Lingaiah Nagarapu^a ; ^{lnagarapuiict@yahoo.com} ; ^{nagarapu@iict.res.in}

关键词：Peptide-coupling ; Anti-proliferative activity ; Molecular docking ; Benzothiazine-piperazine ; HDAC8 ; EHMT2

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

作者：Roheeth Kumar Pavana^a ; Shruti Choudhary^a ; Anja Bastian^b ; Michael A. Ihnat^c ; Ruoli Bai^d ; Ernest Hamel^d ; Aleem Gangjee^a ; ^{gangjee@duq.edu}

关键词：AA ; antiangiogenic agents ; MTA ; microtubule targeting agents ; VEGFR-2 ; vascular endothelial growth factor receptor-2 ; PDGFR-β ; platelet-derived growth factor receptor-β ; CAM ; chorioallantoic membrane ; CA ; combretastatin A-4 ; Pgp ; P-glycoprotein ; EGFR ; epidermal growth factor receptor ; TBS ; Tris-buffered saline ; HRP ; horseradish peroxidase ; PY ; phosphotyrosine

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

4.A novel piperazine linked β-amino alcohols bearing a benzosuberone scaffolds as anti-proliferative agents

作者：Sowmya Vanguru^a ; Lavanya Jilla^a ; Yasodakrishna Sajja^a ; Rajashaker Bantu^a ; Lingaiah Nagarapu^a ; ^{lnagarapuiict@yahoo.com} ; ^{nagarapu@iict.res.in} ; Jagadeesh Babu Nanubolu^b ; Bala Bhaskar^c ; Nishant Jain^c ; Sreekanth Sivan^d ; Vijjulatha Manga^d

关键词：Benzosuberone ; Piperazine ; β-Amino alcohol ; Anti-proliferative ; Cell lines ; Molecular modeling

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

5.Synthesis, in vitro antitumor activity, dihydrofolate reductase inhibition, DNA intercalation and structure-activity relationship studies of 1,3,5-triazine analogues

作者：Prinka Singla ; Vijay Luxami ; Kamaldeep Paul ; ^{kpaul@thapar.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：DHFR ; dihydrofolate reductase ; ct-DNA ; calf thymus DNA ; NADPH ; nicotinamide adenine dinucleotide phosphate ; TGI ; total growth inhibition ; LC50 ; 50% lethal concentration ; GI50 ; 50% growth inhibition ; IC50 ; 50% inhibitory concentration ; Ka ; binding constant

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2

作者：Silvia Salerno^a ; Anna Maria Marini^a ; ^{marini@unipi.it" class="auth_mail" title="E-mail the corresponding author} ; Giacomo Fornaciari^a ; Francesca Simorini^a ; Concettina La Motta^a ; Sabrina Taliani^a ; Stefania Sartini^a ; Federico Da Settimo^a ; Aí ; da Nelly Garcí ; a-Argá ; ez^b ; Ornella Gia^b ; Sandro Cosconati^c ; Ettore Novellino^d ; Pilar D'Ocon^e ; Anna Fioravanti^f ; Paola Orlandi^f ; Guido Bocci^f ; Lisa Dalla Via^b

关键词：Tumor angiogenesis ; Receptor tyrosine kinases ; VEGFR ; Kinase inhibitors ; Benzothiopyranopirimidines

刊名：European Journal of Medicinal Chemistry

出版年：2015

7.Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines

作者：Nikhil Reddy Madadi ; Narsimha Reddy Penthala ; Venumadhav Janganati ; Peter A. Crooks

关键词：N-Benzyl indole ; Dimethylbarbituric acid ; Percentage growth inhibition ; Growth inhibitory activity (GI50) ; Lethal concentration (LC50)

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：15 January, 2014

8.Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors

作者：Jimin Woo^a ; ^b ; Hyun-Young Kim^a ; Byung Jin Byun^a ; Chong-Hak Chae^a ; Ji Young Lee^a ; ^c ; Shi Yong Ryu^a ; ^c ; Woo-Kyu Park^a ; Heeyeong Cho^a ; ^b ; ^{hycho@krict.re.kr" class="auth_mail} ; Gildon Choi^a ; ^b ; ^{gchoi@krict.re.kr" class="auth_mail}

关键词：EZH2 ; enhancer of zeste homologue 2 ; ELISA ; enzyme-linked immunosorbent assay ; IC50 ; half maximal inhibitory concentration ; GI50 ; half maximal growth-inhibitory concentration ; Ki ; dissociation constant of the enzyme&ndash ; inhibitor complex ; EED ; embryonic ectoderm development ; SUZ12 ; suppressor of zeste 12 homologue

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1 June 2014

9.2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes

作者：Sandra Piras^a ; ^{piras@uniss.it" class="auth_mail} ; Antonio Carta^a ; Irene Briguglio^a ; Paola Corona^a ; Giuseppe Paglietti^a ; Rosaria Luciani^b ; Maria Paola Costi^b ; Stefania Ferrari^b

关键词：Trifluoromehylquinoxaline ; Anticancer agents ; Enzyme inhibition ; Dihydrofolate reductase ; Thymidylate synthase

刊名：European Journal of Medicinal Chemistry

出版年：21 March, 2014

10.Safe and easy route for the synthesis of 1,3-dimethyl-1,2,3-triazolium salt and investigation of its anticancer activities

作者：Jaya P. Shrestha ; Cheng-Wei Tom Chang

关键词：Cancers ; Chemotherapeutics ; Cationic anthraquinones ; Triazoles ; Methylazide

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2013

按检索点细分(16)

关键词(1)

文摘(12)

按出版年细分(16)

2027年及以后(1)

2017年(4)

2016年(1)

2015年(1)

2013年(1)

2010年(1)

2008年(1)

2004年(1)

2002年(1)

2000年(2)

2000年及以前(2)