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内部出版物
SpringerLink电子期刊(4)
Elsevier电子期刊(20)
ACS电子期刊(9)
在“
Elsevier电子期刊
”中,
命中:
20
条,耗时:小于0.01 秒
在所有数据库中总计命中:
33
条
1.
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
作者:
Izzat T. Raheem
;
Michael J. Breslin
;
Christine F
;
ozzi
;
Joy Fuerst
;
Nicole Hill
;
Sarah Huszar
;
Monika K
;
ebo
;
Somang H. Kim
;
Bennett Ma
;
Georgia
McGaughey
;
John J. Renger
;
John D. Schreier
;
Sujata Sharma
;
Sean Smith
;
Jason Uslaner
;
Youwei Yan
;
Paul J. Coleman
;
Christopher D. Cox
关键词:
Phosphodiesterase 10A inhibitor
;
Schizophrenia
;
Hyperlocomotion assay
;
Conditioned avoidance response assay
;
Tetrahydropyridopyrimidine
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2012
2.
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
作者:
Paul J. Coleman
;
John D. Schreier
;
Anthony J. Roecker
;
Swati P. Mercer
;
Georgia
B.
McGaughey
;
Christopher D. Cox
;
George D. Hartman
;
C. Meacham Harrell
;
Duane R. Reiss
;
Scott M. Doran
;
Susan L. Garson
关键词:
Sleep
;
Insomnia
;
Diazepane
;
GPCR antagonist
;
Brain penetration
;
Orexin
;
Receptor
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
3.
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
作者:
Jeffrey Y. Melamed
;
Amy E. Zartman
;
Nathan R. Kett
;
Anthony L. Gotter
;
Victor N. Uebele
;
Duane R. Reiss
;
Cindra L. Condra
;
Christine F
;
ozzi
;
Laura S. Lubbers
;
Blake A. Rowe
;
Georgia
B.
McGaughey
;
Mart
关键词:
uropeptide S receptor
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
4.
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists
作者:
Paul J. Coleman
;
John D. Schreier
;
Georgia
B.
McGaughey
;
Michael J. Bogusky
;
Christopher D. Cox
;
George D. Hartman
;
Richard G. Ball
;
C. Meacham Harrell
;
Duane R. Reiss
;
Thomayant Prueksaritanont
;
Chri
关键词:
Orexin receptor
;
Sleep disorders
;
Diazepanes
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
5.
SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pK
a
in enzyme inhibition
作者:
Hemaka A. Rajapakse
;
Philippe G. Nantermet
;
Harold G. Selnick
;
James C. Barrow
;
Georgia
B.
McGaughey
;
Sanjeev Munshi
;
Stacey R. Lindsley
;
Mary Beth Young
;
Phung L. Ngo
;
M. Katherine Holloway
;
Ming-Tai
关键词:
BACE1
;
Tertiary carbinamine
;
Cell assay
;
Enzyme assay
;
Correlation
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
6.
Identification of a small molecule β-secretase inhibitor that binds without catalytic aspartate engagement
作者:
Thomas G. Steele
;
Ivory D. Hills
;
Ashley A. Noml
;
Pablo de Leó
n ;
Timothy Allison
;
Georgia
McGaughey
;
Dennis Colussi
;
Katherine Tugusheva
;
Sharie J. Haugabook
;
Amy S. Espeseth
;
Paul Zuck
;
Samuel
关键词:
Alzheimer’
;
s disease
;
BACE
;
Aspartyl protease inhibitors
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2009
7.
Conformational analysis of N,N
作者:
Christopher D. Cox
;
Georgia
B.
McGaughey
;
Michael J. Bogusky
;
David B. Whitman
;
Richard G. Ball
;
Christopher J. Winrow
;
John J. Renger
;
Paul J. Coleman
关键词:
Orexin receptor antagonist
;
Diazepane
;
Pi-stacking
;
Macrocyclicization
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2009
8.
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations
作者:
Thomas J. Tucker
;
S
;
eep Saggar
;
John T. Sisko
;
Robert M. Tynebor
;
Theresa M. Williams
;
Peter J. Felock
;
Jessica A. Flynn
;
Ming-Tain Lai
;
Yuexia Liang
;
Georgia
McGaughey
;
Meiquing Liu
;
Mike Miller
;
Gre
关键词:
NNRTI
;
HIV
;
Mutations
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2008
9.
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors
作者:
Stacey R. Lindsley
;
Keith P. Moore
;
Hemaka A. Rajapakse
;
Harold G. Selnick
;
Mary Beth Young
;
Hong Zhu
;
Sanjeev Munshi
;
Lawrence Kuo
;
Georgia
B.
McGaughey
;
Dennis Colussi
;
et al.
关键词:
BACE
;
AD
;
Aspartate protease
;
Macrocycle
;
P-gp
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2007
10.
β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites
作者:
Georgia
B.
McGaughey
;
Dennis Colussi
;
Samuel L. Graham
;
Ming-Tain Lai
;
Sanjeev K. Munshi
;
Philippe G. Nantermet
;
Beth Pietrak
;
Hemaka A. Rajapakse
;
Harold G. Selnick
;
Shaun R. Stauffer
;
et al.
关键词:
BACE
;
Scoring functions
;
Molecular mechanics
;
Tertiary carbinamine inhibitors
;
Molecular modeling
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2007
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