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Wiley电子期刊(1)	NATURE电子期刊(2)	ACS电子期刊(31)
SpringerLink电子期刊(15)	Elsevier电子期刊(67)

在“Elsevier电子期刊”中，命中：67条，耗时：小于0.01 秒

在所有数据库中总计命中：116条

1.Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors

作者：Jeffrey G. Varnes^a ; ^{jeffrey.varnes@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Stefan Geschwindner^b ; Christopher R. Holmquist^a ; Janet Forst^a ; Xia Wang^a ; Niek Dekker^b ; Clay W. Scott^a ; Gaochao Tian^a ; Michael W. Wood^a ; Jeffrey S. Albert^a ; ^{jeffrey.albert@intellisynrd.com" class="auth_mail" title="E-mail the corresponding author}

关键词：PDE10A ; Fragment-based drug discovery ; Fragment-assisted drug discovery ; Phosphodiesterase inhibitor ; Schizophrenia

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.New P2X3 receptor antagonists. Part 1: Discovery and optimization of tricyclic compounds

作者：Gá ; bor Szá ; ntó ; Attila Makó ; Imre Bata ; Bence Farkas ; Sá ; ndor Kolok ; Mó ; nika Vastag ; Attila Cselenyák

关键词：Purinergic receptor ; ATP ; Ion channel ; P2X3 antagonist ; HTS campaign ; Airway hyperractivity ; New binding site ; Chirality

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors

作者：Ting Xiao^a ; ^b ; Rui Liu^c ; ^d ; Christopher G. Proud^c ; ^d ; Ming-Wei Wang^a ; ^{mwwang@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：eEF2K ; Inhibitors ; High-throughput screening ; Luminescence ; MH-1 peptide

刊名：Acta Pharmaceutica Sinica B

出版年：2016

4.Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors

作者：Edward Ofori ; Xue Y. Zhu ; Jagan R. Etukala ; Barbara A. Bricker ; Seth Y. Ablordeppey

关键词：Structure affinity relationship ; CNS ligands ; Antipsychotic ; Multi-receptor ligands ; Dual receptor ligands

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.A novel cell-based duplex high-throughput screening assay combining fluorescent Ca²⁺ measurement with homogeneous time-resolved fluorescence technology

作者：Lá ; szló ; Kiss ; Attila Cselenyák ; Á ; gnes Varga ; Andrá ; s Visegrá ; dy ; ^{visegrady@richter.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：Cell-based assays ; High-throughput screening ; Multiplex assays and technology ; Fluorescent Ca2+ measurement ; HTRF technology

刊名：Analytical Biochemistry

出版年：2016

6.Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

作者：Kai Schiemann^a ; ^{kai.schiemann@merckgroup.com" class="auth_mail" title="E-mail the corresponding author} ; Auré ; lie Mallinger^b ; Dirk Wienke^a ; Christina Esdar^a ; Oliver Poeschke^a ; Michael Busch^a ; Felix Rohdich^a ; Suzanne A. Eccles^b ; Richard Schneider^a ; Florence I. Raynaud^b ; Paul Czodrowski^a ; Djordje Musil^a ; Daniel Schwarz^a ; Klaus Urbahns^a ; Julian Blagg^b

关键词：JMTPOBLXKZZYCU-UHFFFAOYSA-N ; KBXKPZZOWBAGTC-UHFFFAOYSA-N ; ZKGWDQMQMQRGLJ-UHFFFAOYSA-N ; OHNXBYACIOVGBQ-UHFFFAOYSA-N ; MJZXLJIFSOYQOU-UHFFFAOYSA-N ; LZRZCEHXAQZTIA-UHFFFAOYSA-N ; BGVLCUOYRCTJCU-UHFFFAOYSA-N ; UQRFZZAOVZWDSA-UHFFFAOYSA-N ; ZWTOETHVOACJIW-UHFFFAOYSA-N ; DDMBDFURJHEOSG-UHFFFAOYSA-N ; DALLTCCRBXGGIY-UHFFFAOYSA-N ; CISPMBXZQNYLKC-UHFFFAOYSA-N ; UETJKJCLDAZMNX-UHFFFAOYSA-N ; WVZGDHXIWUSKHK-UHFFFAOYSA-N ; MUKGYZFIZLFCGL-IBGZPJMESA-N ; MUKGYZFIZLFCGL-LJQANCHMSA-N ; LCUMHIHAYAXPDL-UHFFFAOYSA-N ; QOHBWKY

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Trypsin inhibitors for the treatment of pancreatitis

作者：Trixi Brandl^a ; ^{trixi.brandl@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Oliver Simic^a ; Philip R. Skaanderup^a ; Kenji Namoto^a ; Frederic Berst^a ; Claus Ehrhardt^a ; Nikolaus Schiering^a ; Irene Mueller^a ; Julian Woelcke^b

关键词：YBZBHUMSHGXQNF-FIBWVYCGSA-N ; AYVQDWAWTUYBGU-RVUATISTSA-N ; PZBPHXPZLFDRAP-REWPJTCUSA-N

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Discovery and optimization of a novel series of highly CNS penetrant M₄ PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

作者：Michael R. Wood^a ; ^c ; ^&dagger ; ; Meredith J. Noetzel^a ; ^b ; ^&dagger ; ; Julie L. Engers^a ; Katrina A. Bollinger^a ; Bruce J. Melancon^a ; ^b ; James C. Tarr^a ; Changho Han^a ; Mary West^a ; Alison R. Gregro^a ; Atin Lamsal^a ; Sichen Chang^a ; Sonia Ajmera^a ; Emery Smith^d ; Peter Chase^d ; Peter S. Hodder^e ; Michael Bubser^a ; Carrie K. Jones^a ; ^b ; ^g ; Corey R. Hopkins^a ; ^b ; ^c ; Kyle A. Emmitte^a ; ^b ; ^c ; Colleen M. Niswender^a ; ^b ; ^g ; Michael W. Wood^f ; Mark E. Duggan^f ; P. Jeffrey Conn^a ; ^b ; ^g ; Thomas M. Bridges^a ; ^b ; ^{thomas.m.bridges@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author} ; Craig W. Lindsley^a ; ^b ; ^c ; ^{craig.lindsley@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：M4 ; Muscarinic acetylcholine receptor ; Positive allosteric modulator (PAM) ; Schizophrenia ; Structure&ndash ; Activity Relationship (SAR)

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors

作者：Matthew G. LaPorte^a ; ; Zhuzhu Wang^a ; ^b ; Raffaele Colombo^a ; Atefeh Garzan^a ; Vsevolod A. Peshkov^a ; Mary Liang^a ; ^b ; Paul A. Johnston^b ; ^c ; Mark E. Schurdak^c ; ^d ; Malabika Sen^e ; Daniel P. Camarco^b ; Yun Hua^b ; Netanya I. Pollock^e ; John S. Lazo^f ; Jennifer R. Grandis^g ; Peter Wipf^a ; ^b ; ^c ; ^d ; ; Donna M. Huryn^a ; ^b ;

关键词：STAT3 inhibitor ; Triazolo-thiadiazines ; Anti-cancer agents ; STAT1

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR

作者：Jayme L. Dahlin^a ; ^b ; J. Willem M. Nissink^c ; Subhashree Francis^d ; Jessica M. Strasser^d ; Kristen John^d ; Zhiguo Zhang^e ; Michael A. Walters^d ; ^{mwalters@umn.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：acetyl-CoA ; acetyl coenzyme A ; ALARM NMR ; a La assay to detect reactive molecules by nuclear magnetic resonance ; Asf1 ; anti-silencing function 1 ; AZ ; AstraZeneca ; BME ; 尾-mercaptoethanol ; BSA ; bovine serum albumin ; CoA ; coenzyme A ; CPM ; N-[4-(7-diethylamino-4-methylcoumarin-3-yl)phenyl]maleimide ; dH3&ndash ; H4 ; Drosophila histone H3&ndash ; H4 ; DMSO ; dimethyl sulfoxide ; DNA ; deoxyribonucleic acid ; DTT ; dithiothreitol ; EDTA ; ethylenediaminetetraacetic acid ; GSH ; Glutathione ; H3K9 ; histone H3 lysine 9

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

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