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Elsevier电子期刊(22)
ACS电子期刊(2)
在“
Elsevier电子期刊
”中,
命中:
22
条,耗时:小于0.01 秒
在所有数据库中总计命中:
24
条
1.
Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles
作者:
Scott P. Webster
;
Margaret Binnie
;
Kirsty M.M. McConnell
;
Karen Sooy
;
Peter Ward
;
Michael F. Greaney
;
Andy Vinter
;
T. David Pallin
;
Hazel
J
.
Dyke
;
Matthew I.A. Gill
;
Ines Warner
;
J
onathan R. Seckl
;
Br
关键词:
11β
;
-Hydroxysteroid dehydrogenase type 1
;
11β
;
-HSD1
;
Drug discovery
;
Metabolic syndrome
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
2.
Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists
作者:
Sue Cramp
;
Hazel
J
.
Dyke
;
Christopher Higgs
;
David E. Clark
;
Matthew Gill
;
Pascal Savy
;
Neil
J
ennings
;
Steve Price
;
Peter M. Lockey
;
Dennis Norman
;
Soraya Porres
;
Francis Wilson
;
Alison
J
ones
;
Nigel R
关键词:
Hit-to-lead
;
Hiatamine H4
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
3.
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity
作者:
Robin D. Clark
;
Nicholas C. Ray
;
Karen Williams
;
Paul Blaney
;
Stuart Ward
;
Peter H. Crackett
;
Christopher Hurley
;
Hazel
J
.
Dyke
;
David E. Clark
;
Peter Lockey
;
Rene Devos
;
Melanie Wong
;
Soraya S. Porre
关键词:
Glucocorticoid receptor (GR) antagonist
;
Pyrazolo-fused azadecalins
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2008
4.
2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists
作者:
Robin D. Clark
;
Nicholas C. Ray
;
Paul Blaney
;
Peter H. Crackett
;
Christopher Hurley
;
Karen Williams
;
Hazel
J
.
Dyke
;
David E. Clark
;
Peter M. Lockey
;
Rene Devos
;
Melanie Wong
;
Anne White
;
J
oseph K. Be
关键词:
Glucocorticoid receptor (GR) antagonists
;
Azadecalin
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2007
5.
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators
作者:
Nicholas C. Ray
;
Robin D. Clark
;
David E. Clark
;
Karen Williams
;
H.G. Hickin
;
Peter H. Crackett
;
Hazel
J
.
Dyke
;
Peter M. Lockey
;
Melanie Wong
;
René
;
Devos
;
Anne White
;
J
oseph K. Belanoff
关键词:
Glucocorticoid
;
Depression
;
Psychotic
;
Antagonist
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2007
6.
Quinazoline and benzimidazole MCH-1R antagonists
作者:
Rosa Arienzo
;
Sue Cramp
;
Hazel
J
.
Dyke
;
Peter M. Lockey
;
Dennis Norman
;
Alan G. Roach
;
Phil Smith
;
Melanie Wong
;
Stephen P. Wren
关键词:
Obesity
;
Melanin-concentrating hormone
;
MCH-1
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2007
7.
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
作者:
Steve Price
;
Walter Bordogna
;
Ruth Braganza
;
Richard
J
. Bull
;
Hazel
J
.
Dyke
;
Sophie Gardan
;
Matthew Gill
;
Neil V. Harris
;
Robert A. Heald
;
Marco van den Heuvel
;
et al.
关键词:
Histone deacetylase inhibitors
;
HDAC
;
Hydroxamic acids
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2007
8.
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
作者:
Steve Price
;
Walter Bordogna
;
Richard
J
. Bull
;
David E. Clark
;
Peter H. Crackett
;
Hazel
J
.
Dyke
;
Matthew Gill
;
Neil V. Harris
;
J
ulia Gorski
;
J
ulia Lloyd
;
et al.
关键词:
Histone deacetylase inhibitors
;
HDAC
;
Hydroxamic acids
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2007
9.
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure??????activity relationships
作者:
Buckley
;
George M.
;
Davies
;
Natasha
;
Dyke
;
Hazel
J
.
;
Gilbert
;
Philip
J
.
;
Hannah
;
Duncan R.
;
et. al.
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2005
10.
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors
作者:
Helen L. Birch
;
George M. Buckley
;
Natasha Davies
;
Hazel
J
.
Dyke
;
Elizabeth
J
. Frost
;
Philip
J
. Gilbert
;
Duncan R. Hannah
;
Alan F. Haughan
;
Michael
J
. Madigan
;
Trevor Morgan
et al.
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2005
1
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