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Elsevier电子期刊(243)
在“
Elsevier电子期刊
”中,
命中:
243
条,耗时:0.0549731 秒
在所有数据库中总计命中:
348
条
1.
IMI - oral biopharmaceutics tools project - evaluation of bottom-up
PBPK
prediction success part 1: Characterisation of the OrBiTo database of compounds
作者:
Alison Margolskee
a
;
alison.margolskee@manchester.ac.uk
;
Adam S. Darwich
a
;
Xavier Pepin
b
;
c
;
Shriram M. Pathak
d
;
Michael B. Bolger
e
;
Leon Aarons
a
;
Amin Rostami-Hodjegan
a
;
d
;
Jonas Angstenberger
f
;
Franziska Graf
f
;
Loic Laplanche
f
;
Thomas Mü
;
ller
f
;
Sara Carlert
g
;
Pankaj Daga
h
;
Dó
;
nal Murphy
b
;
Christer Tannergren
g
;
Mohammed Yasin
b
;
Susanne Greschat-Schade
i
;
Wolfgang Mü
;
ck
i
;
Uwe Muenster
i
;
Dorina van der Mey
i
;
Kerstin Julia Frank
j
;
Richard Lloyd
k
;
Lieve Adriaenssen
l
;
Jan Bevernage
l
;
Loeckie De Zwart
l
;
Dominique Swerts
l
;
Christophe Tistaert
l
;
An Van Den Bergh
l
;
Achiel Van Peer
l
;
Stefania Beato
m
;
Anh-Thu Nguyen-Trung
m
;
Joanne Bennett
n
;
Mark McAllister
n
;
Mei Wong
n
;
Patricia Zane
o
;
Cé
;
line Ollier
c
;
Pascale Vicat
c
;
Markus Kolhmann
p
;
Alexander Marker
p
;
Priscilla Brun
c
;
Florent Mazuir
c
;
Sté
;
phane Beilles
c
;
Marta Venczel
p
;
Xavier Boulenc
c
;
Petra Loos
p
;
Hans Lennernä
;
s
q
;
Bertil Abrahamsson
g
关键词:
API
;
active pharmaceutical ingredient
;
AUC
;
area under the curve
;
BCS
;
biopharmaceutics classification system
;
BP
;
blood-to-plasma ratio
;
Cmax
;
maximum concentration
;
CL
;
clearance
;
Do
;
dose number according to BCS
;
DDI
;
drug-drug interaction
;
EFPIA
;
European Federation of Pharmaceutical Industries and Associations
;
Foral
;
absolute oral bioavailability
;
Frel
;
relative bioavailability
;
fup
;
fraction unbound in plasma
;
IMI
;
Innovative Medicines Initiative
;
LogP
;
logarithm of the octanol/water part
刊名:European Journal of Pharmaceutical Sciences
出版年:2017
2.
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up
PBPK
prediction success part 2: An introduction to the simulation exercise and overview of results
作者:
Alison Margolskee
a
;
alison.margolskee@manchester.ac.uk
;
Adam S. Darwich
a
;
Xavier Pepin
b
;
c
;
Leon Aarons
a
;
Aleksandra Galetin
a
;
Amin Rostami-Hodjegan
a
;
d
;
Sara Carlert
e
;
Maria Hammarberg
e
;
Constanze Hilgendorf
e
;
Pernilla Johansson
e
;
Eva Karlsson
e
;
Dó
;
nal Murphy
b
;
Christer Tannergren
e
;
Helena Thö
;
rn
e
;
Mohammed Yasin
b
;
Florent Mazuir
c
;
Olivier Nicolas
c
;
Sergej Ramusovic
f
;
Christine Xu
g
;
Shriram M. Pathak
d
;
Timo Korjamo
h
;
Johanna Laru
b
;
h
;
Jussi Malkki
h
;
Sari Pappinen
h
;
Johanna Tuunainen
h
;
Jennifer Dressman
i
;
Simone Hansmann
i
;
Edmund Kostewicz
i
;
Handan He
j
;
Tycho Heimbach
j
;
Fan Wu
j
;
Carolin Hoft
k
;
Loic Laplanche
k
;
Yan Pang
k
;
Michael B. Bolger
l
;
Eva Huehn
l
;
Viera Lukacova
l
;
James M. Mullin
l
;
Ke X. Szeto
l
;
Chester Costales
m
;
Jian Lin
m
;
Mark McAllister
n
;
Sweta Modi
m
;
Charles Rotter
m
;
Manthena Varma
n
;
Mei Wong
n
;
Amitava Mitra
o
;
Jan Bevernage
p
;
Jeike Biewenga
p
;
Achiel Van Peer
p
关键词:
API
;
Active pharmaceutical ingredient
;
AUC
;
Area under the curve
;
BCS
;
Biopharmaceutics classification system
;
BE
;
Bioequivalence
;
BP
;
Blood-to-plasma ratio
;
CL
;
Clearance
;
CL/F
;
Apparent clearance
;
Cmax
;
Maximum concentration
;
Do
;
Dose number
;
fa
;
Fraction absorbed
;
FIM
;
First in man
;
Foral
;
Absolute oral bioavailability
;
Frel
;
Relative bioavailability
;
fup
;
Fraction unbound in plasma
;
IMI
;
Innovative Medicines Initiative
;
i.v.
;
Intravenous
;
IR
;
Immediate release
;
LogP
;
Logarithm of the octanol
刊名:European Journal of Pharmaceutical Sciences
出版年:2017
3.
Physiologically based pharmacokinetic toolkit to evaluate environmental exposures: Applications of the dioxin
model
to study real life exposures
作者:
Claude Emond
a
;
claude.emond@biosmc.com
;
Patricia Ruiz
b
;
Moiz Mumtaz
b
关键词:
Berkeley-Madonna
;
Dioxin
;
PBPK
;
Risk assessment
刊名:Toxicology and Applied Pharmacology
出版年:2017
4.
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up
PBPK
prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
作者:
Adam S. Darwich
a
;
Alison Margolskee
a
;
alison.margolskee@manchester.ac.uk
;
Xavier Pepin
b
;
c
;
Leon Aarons
a
;
Aleksandra Galetin
a
;
Amin Rostami-Hodjegan
a
;
d
;
Sara Carlert
e
;
Maria Hammarberg
e
;
Constanze Hilgendorf
e
;
Pernilla Johansson
e
;
Eva Karlsson
e
;
Dó
;
nal Murphy
b
;
Christer Tannergren
e
;
Helena Thö
;
rn
e
;
Mohammed Yasin
b
;
Florent Mazuir
c
;
Olivier Nicolas
c
;
Sergej Ramusovic
f
;
Christine Xu
g
;
Shriram M. Pathak
d
;
Timo Korjamo
h
;
Johanna Laru
b
;
h
;
Jussi Malkki
h
;
Sari Pappinen
h
;
Johanna Tuunainen
h
;
Jennifer Dressman
i
;
Simone Hansmann
i
;
Edmund Kostewicz
i
;
Handan He
j
;
Tycho Heimbach
j
;
Fan Wu
j
;
Carolin Hoft
k
;
Yan Pang
k
;
Michael B. Bolger
l
;
Eva Huehn
l
;
Viera Lukacova
l
;
James M. Mullin
l
;
Ke X. Szeto
l
;
Chester Costales
m
;
Jian Lin
m
;
Mark McAllister
n
;
Sweta Modi
m
;
Charles Rotter
m
;
Manthena Varma
n
;
Mei Wong
n
;
Amitava Mitra
o
;
Jan Bevernage
p
;
Jeike Biewenga
p
;
Achiel Van Peer
p
;
Richard Lloyd
q
关键词:
AFE
;
Average Fold Error
;
AAFE
;
Absolute Average Fold Error
;
API
;
Active pharmaceutical ingredient
;
AUC
;
Area under the curve
;
BCS
;
Biopharmaceutics classification system
;
BE
;
Bioequivalence
;
BP
;
Blood-to-plasma ratio
;
CCC
;
Concordance Correlation Coefficient
;
CL
;
Clearance
;
CL/F
;
Apparent clearance
;
Cmax
;
Maximum concentration
;
Do
;
Dose number
;
fa
;
Fraction absorbed
;
FE
;
Fold Error
;
FIM
;
First In Man
;
Foral
;
Absolute oral bioavailability
;
Frel
;
Relative bioavailability
;
fup
;
fraction unbound in
刊名:European Journal of Pharmaceutical Sciences
出版年:2017
5.
Prediction of pharmacokinetic behavior of schisandrin a and schisandrin in rats and
human
using
PBPK
model
ing
作者:
Bu Fengjiao
;
Zhang Hongyan
;
Li Lei
;
Xiaoqiang Xiang
刊名:Drug Metabolism and Pharmacokinetics
出版年:2017
6.
Development of a
PBPK
model
of thiocyanate in rats with an extrapolation to
human
s: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid
作者:
Marie-Emilie Willemin
;
Annie Lumen
;
Annie.Lumen@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author
关键词:
Thiocyanate
;
Bayesian
;
PBPK
model
;
NIS
;
TPO
;
Thyroid
刊名:Toxicology and Applied Pharmacology
出版年:2016
7.
PBPK
model
ing and simulation in drug research and development
作者:
Xiaomei Zhuang
a
;
Chuang Lu
b
;
chuang.lu@biogen.com" class="auth_mail" title="E-mail the corresponding author
关键词:
PBPK
;
PK prediction
;
Absorption
;
Metabolism
;
Drug&ndash
;
drug interaction
;
Special population
刊名:Acta Pharmaceutica Sinica B
出版年:2016
8.
Model
ling ecological and
human
exposure to POPs in Venice lagoon. Part I — Application of MERLIN-Expo tool for integrated exposure assessment
作者:
Elisa Giubilato
a
;
Artur Radomyski
a
;
Andrea Critto
a
;
Philippe Ciffroy
b
;
Cé
;
line Brochot
c
;
Lisa Pizzol
a
;
Antonio Marcomini
a
;
marcom@unive.it" class="auth_mail" title="E-mail the corresponding author
关键词:
Integrated exposure assessment
;
Exposure
model
;
Aquatic food web
;
Persistent organic pollutants
;
Human
internal exposure
;
PBPK
刊名:Science of the Total Environment
出版年:2016
9.
PBPK
model
ing of the cis- and trans-permethrin isomers and their major urinary metabolites in rats
作者:
Marie-Emilie Willemin
a
;
b
;
1
;
Sophie Desmots
c
;
Rozenn Le Grand
d
;
Franç
;
ois Lestremau
e
;
Florence A. Zeman
a
;
Eric Leclerc
b
;
Christian Moesch
d
;
Cé
;
line Brochot
a
;
celine.brochot@ineris.fr" class="auth_mail" title="E-mail the corresponding author
关键词:
PBPK
model
;
cis/trans-Permethrin
;
3-Phenoxybenzoic acid
;
cis- and trans-3-(2
;
2 dichlorovinyl)-2
;
2-dimethyl-(1-cyclopropane) carboxylic acid
;
Bayesian calibration
;
Metabolites
刊名:Toxicology and Applied Pharmacology
出版年:2016
10.
Development of a
human
physiologically based pharmacokinetic (
PBPK
)
model
for dermal permeability for lindane
作者:
Megan E. Sawyer
a
;
m.sawyer@snhu.edu" class="auth_mail" title="E-mail the corresponding author
;
Marina V. Evans
b
;
Charles A. Wilson
c
;
Lauren J. Beesley
c
;
Lider S. Leon
c
;
Chris R. Eklund
b
;
Edward L. Croom
b
;
Rex A. Pegram
b
关键词:
PBPK
;
physiologically based pharmacokinetic
model
ing
;
HT
;
high-throughput
;
SC
;
stratum corneum
刊名:Toxicology Letters
出版年:2016
1
2
3
4
5
6
7
8
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