搜索页_+IRAK4

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

外文资源

Elsevier电子期刊(45)

在“Elsevier电子期刊”中，命中：45条，耗时：小于0.01 秒

在所有数据库中总计命中：45条

1.Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

作者：Kaiwei Liang¹ ; ² ; Andrew G. Volk¹ ; ³ ; Jeffrey S. Haug² ; Stacy A. Marshall¹ ; Ashley R. Woodfin¹ ; Elizabeth T. Bartom¹ ; Joshua M. Gilmore² ; Laurence Florens² ; Michael P. Washburn² ; ⁴ ; Kelly D. Sullivan⁵ ; Joaquin M. Espinosa⁵ ; Joseph Cannova⁶ ; ⁷ ; Jiwang Zhang⁶ ; ⁷ ; Edwin R. Smith¹ ; John D. Crispino¹ ; ³ ; ⁸ ; Ali Shilatifard¹ ; ² ; ⁸ ; ⁹ ; ^{ash@northwestern.edu}

关键词：mixed-lineage leukemia ; MLL ; wild-type MLL ; MLL chimera ; UBE2O ; interleukin-1 ; IRAK4 ; IRAK1 ; super elongation complex ; SEC

刊名：Cell

出版年：2017

2.Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

作者：Sarah J. Mancini^a ; Anna D. White^a ; Silvia Bijland^a ; ¹ ; Claire Rutherford^a ; Delyth Graham^a ; Erik A. Richter^b ; Benoit Viollet^c ; ^d ; ^e ; Rhian M. Touyz^a ; Timothy M. Palmer^f ; Ian P. Salt^a ; ^{Ian.Salt@glasgow.ac.uk}

关键词：Adipocyte ; AMP-activated protein kinase ; Inflammation ; Signalling

刊名：Molecular and Cellular Endocrinology

出版年：2017

3.Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors

作者：Jennifer Hanisak^a ; ^{jennifer.hanisak@merck.com" class="auth_mail" title="E-mail the corresponding author} ; W. Michael Seganish^a ; William T. McElroy^a ; Haiquin Tang^a ; Rui Zhang^a ; Hon-Chung Tsui^a ; Theirry Fischmann^a ; Deen Tulshian^a ; James Tata^a ; Christopher Sondey^b ; Kristine Devito^b ; James Fossetta^c ; Charles G. Garlisi^b ; Daniel Lundell^c ; Xiaoda Niu^b

关键词：IRAK4 ; Interleukin receptor-associated kinases ; Toll-like receptors ; Inflammation ; SAR

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Association of polymorphisms in the MyD88, IRAK4 and TRAF6 genes and susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a southern Han Chinese population

作者：Congcong Guo^a ; ¹ ; Liju Zhang^a ; ¹ ; Lihong Nie^b ; ¹ ; Na Zhang^a ; Di Xiao^a ; Xingguang Ye^a ; Meiling Ou^a ; Yang Liu^a ; Baohuan Zhang^a ; Man Wang^a ; Hansheng Lin^c ; Guang Yang^d ; ^e ; ^{guangyangphd@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Chunxia Jing^a ; ^e ; ^{jcxphd@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Genetics ; IRAK4 ; MyD88 ; T2DM ; TRAF6

刊名：Molecular and Cellular Endocrinology

出版年：2016

5.Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

作者：Takahiro Yamamoto ; Naotaka Tsutsumi ; Hidehito Tochio ; Hidenori Ohnishi ; Kazuo Kubota ; Zenichiro Kato ; Masahiro Shirakawa ; Naomi Kondo

关键词：DD ; death domain ; HEK ; human embryonic kidney ; ID ; internal domain ; IRAK ; Interleukin-1 receptor-associated kinase ; MyD88 ; myeloid differentiating factor 88 ; Mal ; MyD88 adaptor-like ; NMR ; nuclear magnetic resonance ; ELISA ; enzyme-linked immunosorbent assay ; TIR domain ; Toll/interleukin-1 receptor homology domain ; WT ; wild type ; SNP ; single nucleotide polymorphism ; IRAK4-DD ; death domain of IRAK4 ; IRAK4-DD ; + ; ID ; death domain and internal domain of IRAK4 ; MyD88-DD ; death domain of MyD88

刊名：Molecular Immunology

出版年：March, 2014

6.IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation

作者：Kidong Kang^a ; ^b ; ¹ ; Minho Won^a ; ¹ ; Jae-Min Yuk^b ; ^c ; ¹ ; Chan-Yong Park^d ; Hee Sun Byun^a ; Kyeong Ah Park^a ; So-Ra Lee^a ; ^b ; Young-Goo Kang^d ; Han-Ming Shen^e ; Ill Young Lee^d ; ^{iylee@krict.re.kr" class="auth_mail" title="E-mail the corresponding author} ; Gang Min Hur^a ; ^b ; ^{gmhur@cnu.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：IinQ ; 2-hydroxy-5 ; 6-dihydroisoindolo[1 ; 2-a]isoquinoline-3 ; 8-dione ; NF-κB ; Nuclear factor-kappa B ; IκBα ; inhibitory kappa B alpha ; TLR ; toll like receptor ; TNFR1 ; tumor necrosis factor receptor 1 ; IKK ; IκB kinase ; LPS ; lipopolysaccharide ; MyD88 ; a myeloid differentiation factor 88 ; IRAK1 ; interleukin-1 receptor kinase 1 ; IRAK4 ; interleukin-1 receptor kinase 1-associated kinase 4 ; TRAF6 ; TNF receptor-associated factor 6 ; MAPK ; mitogen-activated protein kinase ; ERK ; extracellular signal-regulated k

刊名：Biochemical Pharmacology

出版年：2016

7.Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome

作者：Bart Ferwerda^a ; Mercedes Valls Seró ; n^a ; Aldo Jongejan^b ; Aeilko H. Zwinderman^c ; Madelijn Geldhoff^a ; Arie van der Ende^d ; ^e ; Frank Baas^f ; Matthijs C. Brouwer^a ; Diederik van de Beek^a ; ^{D.vandeBeek@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：CSF ; cerebrospinal fluid ; FDR ; False Discovery Rate ; GATK ; genome analysis tool kit ; GOS ; Glasgow Outcome Scale ; HWE ; Hardy&ndash ; Weinberg equilibrium ; IPD ; invasive pneumococcal disease ; LTA ; lipoteichoic acid ; MAF ; minor allele frequency ; MDS ; multidimensional scaling ; NLRs ; NOD-like receptors ; NRLBM ; Netherlands Reference Laboratories For Bacterial Meningitis ; OR ; odds ratio ; PAMPS ; pathogen-associated molecular pattern molecules ; PCR ; polymerase chain reaction ; RVIS ; residual variation intol

刊名：EBioMedicine

出版年：2016

8.IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae

作者：Serge Grazioli^a ; Sara J. Hamilton^b ; Margaret L. McKinnon^b ; Kate L. Del Bel^c ; Linda Hoang^d ; Victoria E. Cook^c ; Kyla J. Hildebrand^c ; Anne K. Junker^c ; Stuart E. Turvey^c ; ^{sturvey@cw.bc.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：Primary immunodeficiency ; IRAK-4 deficiency ; Toll-like receptor signaling ; Streptococcus pneumoniae ; Invasive pneumococcal disease ; Meningitis

刊名：Clinical Immunology

出版年：2016

9.Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4

作者：L. Nathan Tumey^a ; ^{Nathan.tumey@pfizer.com" class="auth_mail} ; Diane H. Boschelli^a ; Niala Bhagirath^a ; Jaechul Shim^a ; Elizabeth A. Murphy^b ; Deborah Goodwin^b ; Eric M. Bennett^c ; Mengmeng Wang^d ; Lih-Ling Lin^b ; Barry Press^a ; Marina Shen^b ; Richard K. Frisbie^a ; Paul Morgan^b ; Shashi Mohan^b ; Julia Shin^b ; Vikram R. Rao^b

关键词：TLR signaling ; Indoloquinoline ; IRAK4 ; Kinase inhibitor ; Inflammation

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：1 May, 2014

10.Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications

作者：Jongwon Lim^a ; ^{jongwon_lim@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Michael D. Altman^b ; James Baker^c ; Jason D. Brubaker^a ; Hongmin Chen^d ; Yiping Chen^d ; Melanie A. Kleinschek^e ; Chaomin Li^a ; Duan Liu^a ; John K.F. Maclean^b ; Erin F. Mulrooney^c ; Jeremy Presland^d ; Larissa Rakhilina^d ; Graham F. Smith^a ; Ruojing Yang^d

关键词：IRAK4 ; N-(1H-Pyrazol-4-yl)carboxamide ; SAR ; Serine&ndash ; threonine kinase ; Kinase inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

按检索点细分(45)

题名(11)

关键词(13)

文摘(35)

按出版年细分(45)

2027年及以后(5)

2017年(2)

2016年(5)

2015年(3)

2013年(7)

2012年(7)

2011年(1)

2010年(3)

2009年(2)

2008年(2)

2007年(3)

2006年(1)

2003年(1)

2000年及以前(3)