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Wiley电子期刊(43)
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Elsevier电子期刊(4298)
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NATURE电子期刊(43)
ACS电子期刊(455)
在“
Elsevier电子期刊
”中,
命中:
4,298
条,耗时:0.0209842 秒
在所有数据库中总计命中:
5,901
条
1.
Structure-guided development of covalent TAK1
inhibitors
作者:
Li Tan
a
;
b
;
j
;
Deepak Gurbani
c
;
d
;
j
;
Ellen L. Weisberg
e
;
f
;
John C. Hunter
c
;
d
;
Lianbo Li
c
;
d
;
Douglas S. Jones
g
;
h
;
Scott B. Ficarro
a
;
b
;
Samar Mowafy
a
;
b
;
i
;
Chun-Pong Tam
a
;
b
;
Suman Rao
a
;
b
;
g
;
Guangyan Du
a
;
b
;
James D. Griffin
e
;
f
;
Peter K. Sorger
g
;
Jarrod A. Marto
a
;
b
;
Kenneth D. Westover
c
;
d
;
Kenneth.Westover@UTSouthwestern.edu
;
Nathanael S. Gray
a
;
b
;
Nathanael_Gray@dfci.harvard.edu
关键词:
Structure-based design
;
TAK1 kinase
inhibitors
;
Covalent
inhibitors
;
2
;
4-Disubstituted pyrimidine
;
Structure-activity relationship
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
2.
An overview of the binding models of FGFR tyrosine
kinases
in complex with small molecule
inhibitors
作者:
Weiyan Cheng
a
;
Mixiang Wang
b
;
Xin Tian
a
;
tianx@zzu.edu.cn
;
Xiaojian Zhang
a
;
firstpha@163.com
关键词:
FGFR
;
Small molecule inhibitor
;
Crystal structure
;
DFG-in/out
;
Irreversible
;
Pharmacological activity
刊名:European Journal of Medicinal Chemistry
出版年:2017
3.
The Strange Case of CDK4/6
Inhibitors
: Mechanisms, Resistance, and Combination Strategies
作者:
Erik S. Knudsen
1
;
2
;
eknudsen@email.arizona.edu
;
Agnieszka K. Witkiewicz
1
;
2
;
3
;
awitki@email.arizona.edu
关键词:
cell cycle
;
cyclin D1
;
E2F
;
RB
;
breast cancer.
刊名:Trends in Cancer
出版年:2017
4.
Class I phosphatidylinositol 3-kinase
inhibitors
for cancer therapy
作者:
Wennan Zhao
&dagger
;
;
Yuling Qiu
&dagger
;
;
Dexin Kong
;
kongdexin@tmu.edu.cn
关键词:
Phosphatidylinositol 3-kinase
;
PI3K inhibitor
;
Drug candidate
;
Cancer therapy
;
PI3K/mTOR selectivity
;
Anticancer
刊名:Acta Pharmaceutica Sinica B
出版年:2017
5.
Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target
inhibitors
Rapamycin, BEZ235, and LY294002
作者:
Alexey Goltsov
a
;
a.goltsov@abertay.ac.uk
;
Ghassan Tashkandi
b
;
s1163633@exseed.ed.ac.uk
;
Simon P. Langdon
b
;
Simon.Langdon@ed.ac.uk
;
David J. Harrison
c
;
David.Harrison@st-andrews.ac.uk
;
James L. Bown
a
;
d
;
j.bown@abertay.ac.uk
关键词:
Kinetic modelling
;
PI3K
;
mTOR1
;
PTEN
;
Rapamycin
;
BEZ235
刊名:European Journal of Pharmaceutical Sciences
出版年:2017
6.
Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family
kinases
作者:
Gen Kano
a
;
b
;
Bruce S. Bochner
c
;
Nives Zimmermann
a
;
d
;
nives.zimmermann@cchmc.org
关键词:
Eosinophils
;
Cell death
刊名:Immunobiology
出版年:2017
7.
Receptor Tyrosine
Kinases
: Translocation Partners in Hematopoietic Disorders
作者:
Katelyn N. Nelson
1
;
Malalage N. Peiris
1
;
April N. Meyer
1
;
Asma Siari
2
;
Daniel J. Donoghue
1
;
3
;
ddonoghue@ucsd.edu
关键词:
leukemia
;
lymphoma
;
oncogenic fusion
;
ALK
;
FGFR
;
PDGFR.
刊名:Trends in Molecular Medicine
出版年:2017
8.
AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts
作者:
Koji Nakamura
;
koji.nakamura@astellas.com
;
Masamichi Inami
;
Hiroki Morio
;
Kenji Okuma
;
Misato Ito
;
Takahisa Noto
;
Shohei Shirakami
;
Jun Hirose
;
Tatsuaki Morokata
关键词:
JAK
;
Inhibitor
;
Cardiac transplantation
;
Allograft rejection
;
Vasculopathy
;
Tacrolimus
刊名:European Journal of Pharmacology
出版年:2017
9.
A graphene oxide-based multiplexed fluorescence assay for the detection of protein kinase activity in cell lysates and the evaluation of protein kinase inhibition
作者:
Yong Huang
;
huangyong_2009@163.com" class="auth_mail" title="E-mail the corresponding author
Author Vitae
;
Huakui Huang
;
Jian Qin
;
Xiaoqian Liu
;
Shulin Zhao
;
zhaoshulin001@163.com" class="auth_mail" title="E-mail the corresponding author
Author Vitae
;
Zhen-Feng Chen
;
Hong Liang
;
hliang@gxnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
Author Vitae
关键词:
Graphene oxide
;
Multiplexed detection
;
Protein kinase
;
Cell lysates
刊名:Sensors & Actuators: B. Chemical
出版年:2017
10.
A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore
作者:
Yihui Shi
;
Jaehyeon Park
;
Chandraiah Lagisetti
;
Wei Zhou
;
Lidia C. Sambucetti
;
Thomas R. Webb
;
thomas.webb@sri.com
关键词:
CLK
;
cdc2-like kinase
;
MDM2
;
mouse double minute 2 homolog
;
Luc
;
luciferase
;
TEA
;
triethylamine
;
DIPEA
;
diisopropylethylamine
;
EtOAc
;
ethyl acetate
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
1
2
3
4
5
6
7
8
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