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Elsevier电子期刊(35)

在“Elsevier电子期刊”中，命中：35条，耗时：0.1039484 秒

在所有数据库中总计命中：60条

1.Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease

作者：Chandra Bhushan Mishra^a ; ¹ ; Shikha Kumari^a ; ¹ ; Apra Manral^a ; ¹ ; Amresh Prakash^b ; ¹ ; Vikas Saini^a ; ¹ ; Andrew M. Lynn^b ; Manisha Tiwari^a ; ^{mtiwari07@gmail.com}

关键词：Alzheimer's disease ; Donepezil derivatives ; Synthesis ; In-vitro ; TEM assay

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

作者：Jakub Jeřá ; bek^a ; ^b ; Elisa Uliassi^a ; Laura Guidotti^a ; Jan Korá ; bečný ; ^c ; ^d ; Ondřej Soukup^c ; ^d ; Vendula Sepsova^e ; Martina Hrabinova^e ; Kamil Kuča^c ; ^d ; Manuela Bartolini^a ; Luis Emiliano Peñ ; a-Altamira^a ; Sabrina Petralla^a ; Barbara Monti^a ; Marinella Roberti^a ; ^{marinella.roberti@unibo.it} ; Maria Laura Bolognesi^a ; ^{marialaura.bolognesi@unibo.it}

关键词：Alzheimer's disease ; Amyloid ; Acetylcholinesterase ; Multitarget compounds ; Neuroinflammation

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.Design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs

作者：Songwen Lin¹ ; Yingbo Li¹ ; Yufen Zheng ; Laichun Luo ; Qi Sun ; ^{sunqi@bjmu.edu.cn} ; Zemei Ge ; Tieming Cheng ; Runtao Li ; ^{lirt@bjmu.edu.cn}

关键词：Multi-target-directed ligands ; Anticancer drugs ; EGFR/HER2 inhibitors ; DNA alkylating agents ; Phosphoramide mustard

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

作者：Dawid Panek^a ; ¹ ; Anna Więckowska^a ; ¹ ; Tomasz Wichur^a ; Marek Bajda^a ; Justyna Godyń^a ; Jakub Jończyk^a ; Kamil Mika^a ; Jana Janockova^b ; Ondrej Soukup^b ; Damijan Knez^c ; Jan Korabecny^b ; Stanislav Gobec^c ; Barbara Malawska^a ; ^{mfmalaws@cyf-kr.edu.pl}

关键词：Alzheimer's disease ; Multifunctional agents ; Acetylcholinesterase inhibitors ; BACE1 inhibitors ; Aβ aggregation ; Molecular docking

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT₆ receptor antagonists. Design, synthesis and biological evaluation

作者：Anna Więckowska^a ; ^{anna.wieckowska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Marcin Kołaczkowski^b ; Adam Bucki^b ; Justyna Godyń^a ; Monika Marcinkowska^b ; Krzysztof Więckowski^c ; Paula Zaręba^a ; Agata Siwek^d ; Grzegorz Kazek^e ; Monika Głuch-Lutwin^d ; Paweł Mierzejewski^f ; Przemysław Bienkowski^f ; Halina Sienkiewicz-Jarosz^f ; Damijan Knez^g ; Tomasz Wichur^a ; Stanislav Gobec^g ; Barbara Malawska^a

关键词：Alzheimer's disease ; Multi-target-directed ligands ; Acetylcholinesterase inhibitors ; Butyrylcholinesterase inhibitors ; 5-HT6 receptor antagonists

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease

作者：Chao Zhang ; ^{chao-zh@163.com" class="auth_mail" title="E-mail the corresponding author} ; Qiao-Yi Du ; Lang-Di Chen ; Wen-Hao Wu ; Si-Yan Liao ; Li-Hong Yu ; Xin-Tong Liang

关键词：Tacrine ; Multi-target-directed ligands ; Alzheimer's disease ; Cholinesterase inhibitors ; Self-induced Aβ aggregation

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer’s disease based on the fusion of donepezil and melatonin

作者：Jin Wang ; Zhi-Min Wang ; Xue-Mei Li ; Fan Li ; Jia-Jia Wu ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Bing Wang ; ^{xbwang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：AchE ; Acetylcholinesterase ; BuChE ; Butyrylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-Amyloid ; CAS ; Catalytic anionic site ; PAS ; Peripheral anionic site ; BBB ; Blood&ndash ; brain barrier ; AβOs ; Soluble Aβ oligomers ; CNS ; Central nervous system ; NFTS ; Neurofibrillary tangles ; ChEs ; Cholinesterases ; ChEIs ; Cholinesterase inhibitors ; CDI ; 1 ; 1&prime ; -Carbonyldiimidazole ; ORAC ; Oxygen radical absorbance capacity ; PAMPA ; Parallel artificial membrane permeation assay

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX

作者：Ladan Pourabdi^a ; Mehdi Khoobi^b ; ^c ; Hamid Nadri^d ; Alireza Moradi^d ; Farshad Homayouni Moghadam^e ; Saeed Emami^f ; Mohammad M. Mojtahedi^a ; ; Ismaeil Haririan^b ; Hamid Forootanfar^g ; Alieh Ameri^h ; Alireza Foroumadi^c ; Abbas Shafiee^c ; ^{ashafiee@ams.ac.ir" class="auth_mail" title="E-mail the corresponding author}

关键词：Acetylcholinesterase ; Butyrylcholinesterase ; 15-Lipoxygenase ; Alzheimer's disease ; Tacrine

刊名：European Journal of Medicinal Chemistry

出版年：2016

9.Structure-guided development of dual β₂ adrenergic/dopamine D₂ receptor agonists

作者：Dietmar Weichert^&dagger ; ; Markus Stanek ; Harald Hü ; bner ; Peter Gmeiner ; ^{peter.gmeiner@fau.de" class="auth_mail" title="E-mail the corresponding author}

关键词：G protein-coupled receptors ; Dopamine receptor ; β2 adrenergic receptor ; Neurodegenerative disorders ; Parkinson&rsquo ; s disease ; Molecular probes ; Polypharmacology

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of 伪7 nicotinic acetylcholine receptor

作者：Ró ; mulo Ará ; oz¹ ; ² ; Monika Bouet³ ; Manuela Bartolini⁴ ; Nicolas Coquelle⁵ ; Jacques-Philippe Colletier⁵ ; ⁶ ; Denis Servent² ; Jordi Molgo¹ ; ² ; Ludovic Jean³ ; Pierre-Yves Renard³

刊名：Biochemical Pharmacology

出版年：2015

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