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Wiley电子期刊(12)	NATURE电子期刊(4)	ACS电子期刊(63)
SpringerLink电子期刊(23)	Elsevier电子期刊(70)

在“Elsevier电子期刊”中，命中：70条，耗时：0.0280138 秒

在所有数据库中总计命中：172条

1.Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

作者：Jakub Jeřá ; bek^a ; ^b ; Elisa Uliassi^a ; Laura Guidotti^a ; Jan Korá ; bečný ; ^c ; ^d ; Ondřej Soukup^c ; ^d ; Vendula Sepsova^e ; Martina Hrabinova^e ; Kamil Kuča^c ; ^d ; Manuela Bartolini^a ; Luis Emiliano Peñ ; a-Altamira^a ; Sabrina Petralla^a ; Barbara Monti^a ; Marinella Roberti^a ; ^{marinella.roberti@unibo.it} ; Maria Laura Bolognesi^a ; ^{marialaura.bolognesi@unibo.it}

关键词：Alzheimer's disease ; Amyloid ; Acetylcholinesterase ; Multitarget compounds ; Neuroinflammation

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Macrophages in oxidative stress and models to evaluate the antioxidant function of dietary natural compounds

作者：Omir Adrian Castaneda^a ; Sheng-Chi Lee^b ; Chi-Tang Ho^c ; Tzou-Chi Huang^d ; ^{tchuang@mail.npust.edu.tw}

关键词：cell model ; epigenetic ; peroxynitrite ; tissue resident macrophages

刊名：Journal of Food and Drug Analysis

出版年：2017

3.N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

作者：Urban Ko&scaron ; ak^a ; Damijan Knez^a ; Nicolas Coquelle^b ; Boris Brus^a ; Anja Pi&scaron ; lar^a ; Florian Nachon^c ; Xavier Brazzolotto^c ; Janko Kos^a ; Jacques-Philippe Colletier^b ; Stanislav Gobec^a ; ^{stanislav.gobec@ffa.uni-lj.si}

关键词：Multitarget-directed ligands ; Butyrylcholinesterase inhibitors ; MAO-B inhibitors ; Alzheimer&rsquo ; s disease

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

4.Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy

作者：Chao Ding^a ; ^b ; Shaopeng Chen^b ; Cunlong Zhang^c ; Guangnan Hu^d ; Wei Zhang^a ; ^b ; Lulu Li^b ; Yu Zong Chen^c ; Chunyan Tan^a ; ^b ; ^{tancy@sz.tsinghua.edu.cn} ; Yuyang Jiang^b ; ^e ; ^{jiangyy@sz.tsinghua.edu.cn}

关键词：EGFR ; HER2 ; HDAC ; Multitarget ; Synergy ; Resistance

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

5.Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors

作者：Li Tan^a ; ^b ; ^j ; Deepak Gurbani^c ; ^j ; Ellen L. Weisberg^e ; ^f ; ^j ; Douglas S. Jones^g ; ^h ; ^j ; Suman Rao^a ; ^b ; ^g ; William D. Singer^c ; ^d ; Faviola M. Bernard^c ; ^d ; Samar Mowafy^a ; ^b ; ⁱ ; Annie Jenney^g ; Guangyan Du^a ; ^b ; Atsushi Nonami^e ; ^f ; James D. Griffin^e ; ^f ; Douglas A. Lauffenburger^h ; Kenneth D. Westover^c ; ^d ; ^{Kenneth.Westover@UTSouthwestern.edu} ; Peter K. Sorger^g ; ^{Peter_Sorger@hms.harvard.edu} ; Nathanael S. Gray^a ; ^b ; ^{Nathanael_Gray@dfci.harvard.edu}

关键词：TAK1 ; Polypharmacology ; Multitarget ; Cancer ; Cytokine secretion

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

6.Mefloquine inhibits voltage dependent Na_v1.4 channel by overlapping the local anaesthetic binding site

作者：Bertin Paiz-Candia^b ; ² ; ¹ ; ^{bertin.paiz@gmail.com} ; Angel A. Islas^a ; ^b ; ¹ ; ^{angelislas@gmail.com} ; Alfredo Sá ; nchez-Solano^a ; ² ; Claudia Mancilla-Simbro^a ; ^{claudia.mancilla@gmail.com} ; Thomas Scior^b ; ^{tscior@gmail.com} ; Lourdes Millan-PerezPeñ ; a^c ; ^{lourdes.millan@correo.buap.mx} ; Eduardo M. Salinas-Stefanon^a ; ^{eduardo.salinas@correo.buap.mx}

关键词：Docking ; Local anaesthetic ; Mefloquine ; Oocytes ; Selectivity filter

刊名：European Journal of Pharmacology

出版年：2017

7.In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition

作者：Malvina Hoxha^a ; ¹ ; Carola Buccellati^a ; ¹ ; Valé ; rie Capra^c ; Davide Garella^b ; Clara Cena^b ; Barbara Rolando^b ; Roberta Fruttero^b ; Silvia Carnevali^a ; Angelo Sala^a ; G.Enrico Rovati^a ; ^{genrico.rovati@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Massimo Bertinaria^b

关键词：AA ; arachidonic acid ; CV ; cardiovascular ; COX ; cyclooxygenase coxibs ; COX-2 ; selective inhibitors ; DMEM ; Dulbecco&rsquo ; s modified eagle&rsquo ; s medium ; EIA ; enzyme immunoassay ; IP ; inositol phosphate ; HEK293 ; human embryonic kidney 293 ; NSAID ; nonsteroidal anti-inflammatory drug ; PG ; prostaglandin ; TXA2 ; thromboxane A2 ; TP ; thromboxane prostanoid receptor

刊名：Pharmacological Research

出版年：2016

8.Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

作者：Laí ; s Flá ; via Nunes Lemes^a ; ^b ; Giselle de Andrade Ramos^a ; ^b ; Andressa Souza de Oliveira^a ; ^b ; Fernanda Motta R. da Silva^c ; Gina de Castro Couto^c ; Marina da Silva Boni^c ; Marcos Jorge R. Guimarã ; es^c ; Isis Nem O. Souza^c ; Manuela Bartolini^d ; Vincenza Andrisano^e ; Patrí ; cia Coelho do Nascimento Nogueira^f ; Edilberto Rocha Silveira^f ; Guilherme D. Brand^g ; Ondřej Soukup^h ; ⁱ ; Jan Korá ; bečný ; ^h ; ⁱ ; Nelilma C. Romeiro^j ; Newton G. Castro^c ; Maria Laura Bolognesi^d ; ^{marialaura.bolognesi@unibo.it" class="auth_mail" title="E-mail the corresponding author} ; Luiz Antonio Soares Romeiro^a ; ^b ; ^{luizromeiro@unb.br" class="auth_mail" title="E-mail the corresponding author}

关键词：Cashew nut shell liquid ; Alzheimer's disease ; Dual binding site AChE inhibitors ; Acetylcholinesterase ; Multitarget compounds

刊名：European Journal of Medicinal Chemistry

出版年：2016

9.Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer’s disease

作者：Shenqi Wei^a ; ^&dagger ; ; Wei Chen^b ; ^&dagger ; ; Jingfang Qin^a ; Yingzi Huangli^b ; Li Wang^a ; Yue Shen^a ; Huang Tang^a ; ^{hyhth@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Oxoisoaporphine derivatives ; Synthesis ; Cholinesterase inhibitors ; β-Amyloid aggregation ; Autophagy

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

作者：Wanli Pan^a ; Ke Hu^b ; Ping Bai^c ; Lintao Yu^a ; Qinge Ma^a ; Tao Li^a ; Xu Zhang^a ; Changzhong Chen^a ; Kelin Peng^a ; Wenmin Liu^a ; ^{liuwm1969@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhipei Sang^a ; ^{sangzhipei@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; Aβ ; β-amyloid peptide ; BBB ; blood&ndash ; brain barrier ; ACh ; acetylcholine ; MTDL ; multitarget-directed ligand ; EeAChE ; electric eel AChE ; CAS ; catalytic anionic site ; PAS ; peripheral anionic site ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT ; thioflavin T ; PAMPA-BBB ; parallel artificial membrane permeation assay of the blood&minus ; brain barrier

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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