搜索页_ NS3/4A

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

外文资源

Elsevier电子期刊(161)

在“Elsevier电子期刊”中，命中：161条，耗时：小于0.01 秒

在所有数据库中总计命中：161条

1.Identification of drug resistance and immune-driven variations in hepatitis C virus (HCV) NS3/4A, NS5A and NS5B regions reveals a new approach toward personalized medicine

作者：Aqsa Ikram^a ; Ayesha Obaid^a ; Faryal Mehwish Awan^a ; Rumeza Hanif^b ; Anam Naz^a ; Rehan Zafar Paracha^c ; Amjad Ali^a ; Hussnain Ahmed Janjua^a ; ^{janjua.hussnain@gmail.com} ; ^{hussnain.janjua@asab.nust.edu.pk}

关键词：Direct acting antiviral drugs ; Drug resistance mutations ; Epitope mutations ; Overlap

刊名：Antiviral Research

出版年：2017

2.Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

作者：Alan Xiangdong Wang^a ; ^{alan.wang@bms.com} ; Jie Chen^a ; Qian Zhao^a ; Li-Qiang Sun^a ; Jacques Friborg^b ; Fei Yu^b ; Dennis Hernandez^b ; Andrew C. Good^c ; Herbert E. Klei^c ; Ramkumar Rajamani^c ; Kathy Mosure^d ; Jay O. Knipe^d ; Danshi Li^d ; Jialong Zhu^d ; Paul C. Levesque^d ; Fiona McPhee^b ; Nicholas A. Meanwell^a ; Paul M. Scola^a ;

关键词：HCV NS3/4A serine protease inhibitors ; Tripeptide acylsulfonamides ; C4 aryl ; C4 hydroxy-proline ; Potent and orally bioavailable ; Cardiovascular profiles

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Regulatory Analysis of Effects of Hepatitis C Virus NS5A Polymorphisms on Efficacy of Elbasvir and Grazoprevir

作者：Takashi E. Komatsu¹ ; ^{takashi.komatsu@fda.hhs.gov} ; Sarita Boyd¹ ; Adam Sherwat¹ ; LaRee Tracy² ; Lisa K. Naeger¹ ; Julian J. O&rsquo ; Rear¹ ; Patrick R. Harrington¹ ; ^{patrick.harrington@fda.hhs.gov}

关键词：DAA ; Replication ; FDA ; Post-Hoc Analysis

刊名：Gastroenterology

出版年：2017

4.Effectiveness of Elbasvir and Grazoprevir Combination, With or Without Ribavirin, for Treatment-Experienced Patients With Chronic Hepatitis C Infection

作者：Paul Kwo¹ ; ^{pkwo@stanford.edu} ; Edward J. Gane² ; Cheng-Yuan Peng³ ; Brian Pearlman⁴ ; John M. Vierling⁵ ; Lawrence Serfaty⁶ ; Maria Buti⁷ ; Stephen Shafran⁸ ; Paul Stryszak⁹ ; Li Lin⁹ ; Jacqueline Gress⁹ ; Stuart Black⁹ ; Frank J. Dutko⁹ ; Michael Robertson⁹ ; Janice Wahl⁹ ; Lisa Lupinacci⁹ ; Eliav Barr⁹ ; Barbara Haber⁹

关键词：Hepatitis C ; Randomized ; Therapy ; C-EDGE Treatment-Experienced

刊名：Gastroenterology

出版年：2017

5.Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease

作者：Hiroki Kataoka^a ; Tomoyuki Ohe^a ; ^{ohe-tm@pha.keio.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Kyoko Takahashi^a ; Shigeo Nakamura^b ; Tadahiko Mashino^a ; ^{mashino-td@pha.keio.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：HCV ; Hepatitis C virus ; NS ; non-structural

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-Naïve or Previously Treated Patients With Hepatitis C Virus Genotype 1 or 3 Infections

作者：Edward J. Gane¹ ; ^{edgane@adhb.govt.nz" class="auth_mail" title="E-mail the corresponding author} ; Christian Schwabe² ; Robert H. Hyland³ ; Yin Yang³ ; Evguenia Svarovskaia³ ; Luisa M. Stamm³ ; Diana M. Brainard³ ; John G. McHutchison³ ; Catherine A. Stedman⁴

关键词：Clinical Trial ; LEPTON ; Difficult to Treat ; Time of Treatment

刊名：Gastroenterology

出版年：2016

7.Direct anti-HCV agents

作者：Xingquan Zhang ^{xiz002@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Hepatitis C virus ; Cure HCV ; Sustained virologic response ; Direct antiviral agents ; NS3/4A protease inhibitor

刊名：Acta Pharmaceutica Sinica B

出版年：2016

8.Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320

作者：Christophe C. Parsy^a ; ^{christophe.parsy@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Franç ; ois-René ; Alexandre^a ; Valé ; rie Bidau^a ; ^&dagger ; ; Florence Bonnaterre^a ; ^&dagger ; ; Guillaume Brandt^a ; Catherine Caillet^a ; ^&dagger ; ; Sylvie Cappelle^a ; Dominique Chaves^a ; ^&dagger ; ; Thierry Convard^a ; Michel Derock^a ; ^&dagger ; ; Damien Gloux^a ; ^&dagger ; ; Yann Griffon^a ; ^&dagger ; ; Lisa B. Lallos^b ; ^&dagger ; ; Frederic Leroy^a ; ^&dagger ; ; Michel Liuzzi^b ; ^&dagger ; ; Anna-Giulia Loi^b ; ^&dagger ; ; Laure Moulat^a ; ^&dagger ; ; Musiu Chiara^b ; ^&dagger ; ; Houcine Rahali^a ; Virginie Roques^a ; ^&dagger ; ; Elodie Rosinovsky^a ; ^&dagger ; ; Simon Savin^a ; ^&dagger ; ; Maria Seifer^b ; David Standring^b ; ^&dagger ; ; Dominique Surleraux^a ; ^&dagger ;

关键词：Hepatitis C ; HCV NS3/4A protease inhibitors ; Macrocycle

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

9.Hepatitis C virus NS3/4a protease inhibitors

作者：John A McCauley ^{john_mccauley@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Michael T Rudd

刊名：Current Opinion in Pharmacology

出版年：2016

10.Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Genotype 1 Hepatitis C Virus Infection in an Open-Label, Phase 2 Trial

作者：Eric Lawitz¹ ; ^{lawitz@txliver.com" class="auth_mail" title="E-mail the corresponding author} ; Nancy Reau² ; Federico Hinestrosa³ ; Mordechai Rabinovitz⁴ ; Eugene Schiff⁵ ; Aasim Sheikh⁶ ; Ziad Younes⁷ ; Robert Herring Jr.⁸ ; K. Rajender Reddy⁹ ; Tram Tran¹⁰ ; Michael Bennett¹¹ ; Ronald Nahass¹² ; Jenny C. Yang¹³ ; Sophia Lu¹³ ; Hadas Dvory-Sobol¹³ ; Luisa M. Stamm¹³ ; Diana M. Brainard¹³ ; John G. McHutchison¹³ ; Brian Pearlman¹⁴ ; Mitchell Shiffman¹⁵ ; Trevor Hawkins¹⁶ ; Michael Curry¹⁷ ; Ira Jacobson¹⁸

关键词：Direct-Acting Antiviral Agent ; NS5A ; NS5B ; NS3/4A

刊名：Gastroenterology

出版年：2016

按检索点细分(161)

题名(87)

关键词(36)

文摘(111)

按出版年细分(161)

2027年及以后(6)

2017年(4)

2016年(14)

2015年(10)

2013年(13)

2012年(29)

2011年(13)

2010年(20)

2009年(15)

2008年(13)

2007年(5)

2006年(4)

2005年(2)

2004年(2)

2003年(3)

2002年(1)

2000年(1)

2000年及以前(6)