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Elsevier电子期刊(6353)

在“Elsevier电子期刊”中，命中：6,353条，耗时：小于0.01 秒

在所有数据库中总计命中：6,353条

1.Simultaneous Inhibition of PI3Kδ and PI3Kα Induces ABC-DLBCL Regression by Blocking BCR-Dependent and -Independent Activation of NF-κB and AKT

作者：Juliane Paul¹ ; ⁵ ; Maurice Soujon¹ ; ⁵ ; Antje M. Wengner¹ ; Sabine Zitzmann-Kolbe¹ ; Andrea Sturz¹ ; Katja Haike¹ ; Koh Hui Keng Magdalene² ; Sze Huey Tan³ ; Martin Lange¹ ; Soo Yong Tan² ; ⁶ ; Dominik Mumberg¹ ; Soon Thye Lim⁴ ; Karl Ziegelbauer¹ ; Ningshu Liu¹ ; ^{ningshu.liu@bayer.com}

关键词：PI3Kα ; PI3Kδ ; NF-κB ; BCR ; MYD88 ; CARD11 ; DLBCL ; follicular lymphoma ; ibrutinib-resistance ; copanlisib

刊名：Cancer Cell

出版年：2017

2.PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice

作者：Angelo Maffei^a ; Giuseppe Cifelli^a ; Raimondo Carnevale^a ; Roberta Iacobucci^a ; Fabio Pallante^a ; Valentina Fardella^a ; Stefania Fardella^a ; Emilio Hirsch^b ; Giuseppe Lembo^a ; ^c ; Daniela Carnevale^a ; ^c ; ^{Daniela.carnevale@uniroma1.it}

关键词：Diabetes mellitus ; Cardiomyopathy ; Investigational drugs ; PI3Kγ protein ; Mouse

刊名：Revista Española de Cardiología (English Edition)

出版年：2017

3.La inhibición de la PI3Kγ protege contra la miocardiopatía diabética en ratones

关键词：Diabetes mellitus ; Miocardiopatía ; Fá ; rmacos en investigación ; Proteí ; na PI3Kγ ; Ratón

刊名：Revista Española de Cardiología

出版年：2017

4.Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

作者：Alexey Goltsov^a ; ^{a.goltsov@abertay.ac.uk} ; Ghassan Tashkandi^b ; ^{s1163633@exseed.ed.ac.uk} ; Simon P. Langdon^b ; ^{Simon.Langdon@ed.ac.uk} ; David J. Harrison^c ; ^{David.Harrison@st-andrews.ac.uk} ; James L. Bown^a ; ^d ; ^{j.bown@abertay.ac.uk}

关键词：Kinetic modelling ; PI3K ; mTOR1 ; PTEN ; Rapamycin ; BEZ235

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

5.Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis

作者：Sabrina Giacoppo^a ; Federica Pollastro^b ; Gianpaolo Grassi^c ; Placido Bramanti^a ; Emanuela Mazzon^a ; ^{emazzon.irccs@gmail.com}

关键词：Cannabidiol ; Multiple sclerosis ; PI3K/Akt/mTOR pathway ; BDNF ; Inflammation ; Neuronal survival

刊名：Fitoterapia

出版年：2017

6.Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors

作者：Ina Terstiege^a ; ^{Ina.Terstiege@astrazeneca.com} ; Matthew Perry^a ; Jens Petersen^b ; Christian Tyrchan^a ; Tor Svensson^a ; Helena Lindmark^b ; Linda Ö ; ster^b

关键词：Phosphoinositide 3-kinase ; PI3Kδ inhibitor ; Aminopyrazine ; Inflammation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

7.Inhibiting PI3K-AKt signaling pathway is involved in antitumor effects of ginsenoside Rg3 in lung cancer cell

作者：Qipeng Xie^a ; ¹ ; Huaikai Wen^a ; ¹ ; Qiong Zhang^b ; Weihe Zhou^c ; Xiaoming Lin^d ; Deyao Xie^d ; Yu Liu^d ; ^{48936053@qq.com}

关键词：Ginsenoside Rg3 ; Lung cancer ; Apoptosis ; PI3K/Akt

刊名：Biomedicine & Pharmacotherapy

出版年：2017

8.Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

作者：Lan-Ying Qin ; ^{lan-ying.qin@bms.com} ; Zheming Ruan ; Robert J. Cherney ; T.G. Murali Dhar ; James Neels ; Carolyn A. Weigelt ; John S. Sack ; Anurag S. Srivastava ; Lyndon A.M. Cornelius ; Joseph A. Tino ; Kevin Stefanski ; Xiaomei Gu ; Jenny Xie ; Vojkan Susulic ; Xiaoxia Yang ; Melissa Yarde-Chinn ; Stacey Skala ; Ruth Bosnius ; Christine Goldstein ; Paul Davies ; Stefan Ruepp ; Luisa Salter-Cid ; Rajeev S. Bhide ; Michael A. Poss

关键词：PI3Kδ ; 7-Phenylpyrrolo[2 ; 1-f][12 ; 4]triazin-4-amine ; Autoimmune diseases ; Rheumatoid arthritis ; Phosphoinositide 3-kinases

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

9.Epigallocatechin-3-gallate inhibits adipogenesis through down-regulation of PPARγ and FAS expression mediated by PI3K-AKT signaling in 3T3-L1 cells

作者：Mengqing Wu^a ; ^b ; ¹ ; Dan Liu^a ; ^b ; ¹ ; Rong Zeng^a ; ^b ; ¹ ; Tao Xian^a ; ^b ; Yi Lu^a ; ^b ; Guohua Zeng^a ; ^b ; Zhangzetian Sun^c ; Bowei Huang^c ; Qiren Huang^a ; ^b ; ^{qrhuang@ncu.edu.cn}

关键词：4E-BP1 ; 4E-binding protein1 ; C/EBP ; CCAAT/ enhancer binding proteins ; EGCG ; epigallocatechin-3-gallate ; FAS ; fatty acid synthase ; FOXO1 ; forkhead box-O1 ; HFD ; high fat diet ; IGF ; insulin-like growth factor ; IR ; insulin resistance ; IRS1 ; insulin receptor substrate 1 ; MSCs ; mesenchymal stem cells ; PGC1 ; PPARγ coactivator 1 ; PI3K ; phosphatidylinositol 3 kinase ; PPARγ ; peroxisome proliferator activated receptor γ ; Rb ; retinoblastoma protein ; TG ; triglyceride ; TIF2 ; transcriptional intermediary facto

刊名：European Journal of Pharmacology

出版年：2017

10.Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

作者：Michelle S. Miller^a ; Sweta Maheshwari^b ; Fiona M. McRobb^c ; Kenneth W. Kinzler^d ; L. Mario Amzel^b ; Bert Vogelstein^d ; Sandra B. Gabelli^a ; ^b ; ^e ; ^{gabelli@jhmi.edu}

关键词：PIK3CA ; PI3K ; PIP2 ; PIP3 ; Fragment-based drug discovery

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

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