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Elsevier电子期刊(82)

在“Elsevier电子期刊”中，命中：82条，耗时：0.034983 秒

在所有数据库中总计命中：127条

1.Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache

作者：Maria-Jesus Blanco^a ; ^{blanco_maria@lilly.com} ; Dana R. Benesh^a ; James A. Knobelsdorf^a ; Albert Khilevich^a ; Guillermo S. Cortez^a ; Fese Mokube^a ; Thomas D. Aicher^b ; Todd M. Groendyke^b ; Fredrik P. Marmsater^b ; Tony P. Tang^b ; Kirk W. Johnson^a ; Amy Clemens-Smith^a ; Mark A. Muhlhauser^a ; Steven Swanson^a ; John Catlow^a ; Renee Emkey^a ; Michael P. Johnson^a ; Jeffrey M. Schkeryantz^a

关键词：Allosteric modulators ; mGlu2 ; PAMs ; Metabotropic glutamate receptor ; CysLT1 ; Migraine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.ADX71943 and ADX71441, novel positive allosteric modulators of the GABA_B receptor with distinct central/peripheral profiles, show efficacy in the monosodium iodoacetate model of chronic osteoarthritis pain in the rat

作者：Mikhail Kalinichev^a ; ^{mikhail.kalinichev@ipsen.com} ; Tansy Donovan-Rodriguez^a ; Franç ; oise Girard^a ; Hasnaá ; Haddouk^a ; Isabelle Royer-Urios^a ; Manfred Schneider^a ; Simon T. Bate^b ; Cheryl Marker^c ; James D. Pomonis^c ; Sonia Poli^a

关键词：Allosteric modulation ; GABA ; GABAB ; Chronic pain ; Osteoarthritis ; ADX71943 ; ADX71441 ; Inflammatory pain ; Neuropathic pain

刊名：European Journal of Pharmacology

出版年：2017

3.The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptors

作者：Maria C. Olianas ; ^{molianas@unica.it} ; Simona Dedoni ; Pierluigi Onali

关键词：CGP7930 (PubChem CID ; 5024764) ; GS39783 (PubChem CID ; 6604928) ; (-)-baclofen (PubChem CID ; 44602) ; SKF97541 (PubChem CID ; 5230) ; CGP55845 (PubChem CID ; 5311042) ; CGP54626 (PubChem CID ; 197584) ; phorbol 12-myristate 13 acetate (PubChem CID ; 27924) ; Go 6850 (PubChem CID ; 2396) ; 5Z-7-oxozeaenol (PubChem CID ; 9863776) ; GW5074 (PubChem CID ; 5924208)

刊名：European Journal of Pharmacology

出版年：2017

4.Triazolopyridine ethers as potent, orally active mGlu₂ positive allosteric modulators for treating schizophrenia

作者：Mendi A. Higgins ; ^{mendi.higgins@bms.com} ; Lawrence R. Marcin ; F. Christopher Zusi ; Robert Gentles ; Min Ding ; Bradley C. Pearce ; Amy Easton ; Walter A. Kostich ; Matthew A. Seager ; Clotilde Bourin ; Linda J. Bristow ; Kim A. Johnson ; Regina Miller ; John Hogan ; Valerie Whiterock ; Michael Gulianello ; Meredith Ferrante ; Yanling Huang ; Adam Hendricson ; Andrew Alt ; John E. Macor ; Joanne J. Bronson

关键词：Schizophrenia ; mGlu2 ; Metabotropic glutamate receptors ; Triazolopyridine

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

5.Challenges in the development of an M₄ PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

作者：Michael R. Wood^a ; ^c ; ¹ ; Meredith J. Noetzel^a ; ^b ; ¹ ; Michael S. Poslusney^a ; ¹ ; Bruce J. Melancon^a ; ^b ; James C. Tarr^a ; Atin Lamsal^a ; Sichen Chang^a ; Vincent B. Luscombe^a ; ^b ; Rebecca L. Weiner^a ; ^b ; Hyekyung P. Cho^a ; ^b ; Michael Bubser^a ; Carrie K. Jones^a ; ^b ; ^e ; Colleen M. Niswender^a ; ^b ; ^e ; Michael W. Wood^d ; Darren W. Engers^a ; ^b ; Nicholas J. Brandon^d ; Mark E. Duggan^d ; P. Jeffrey Conn^a ; ^b ; ^e ; Thomas M. Bridges^a ; ^b ; ^{thomas.m.bridges@vanderbilt.edu} ; Craig W. Lindsley^a ; ^b ; ^c ; ^{craig.lindsley@vanderbilt.edu}

关键词：M4 ; Muscarinic acetylcholine receptor ; Positive allosteric modulator (PAM) ; Schizophrenia ; Structure-activity relationship (SAR)

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

作者：L. Lundströ ; m^a ; C. Bissantz^b ; J. Beck^a ; M. Dellenbach^a ; T.J. Woltering^b ; J. Wichmann^b ; S. Gatti^a ; ^{silviagatti.mcarthur@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Metabotropic glutamate receptor ; mGlu2 ; mGlu3 ; mGluR ; Negative allosteric modulators ; Positive allosteric modulators ; LY354740 ; LY487379

刊名：Neuropharmacology

出版年：2016

7.Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats

作者：Agnieszka Nikiforuk ; ^{nikifor@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author} ; Tomasz Kos ; Małgorzata Hołuj ; Agnieszka Potasiewicz ; Piotr Popik

关键词：Alpha 7 nicotinic acetylcholine receptors ; Positive allosteric modulators ; Schizophrenia ; Animal models ; Cognition ; Ketamine

刊名：Neuropharmacology

出版年：2016

8.Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

作者：D.M. Bortz^a ; B.A. Upton^b ; J.D. Mikkelsen^c ; J.P. Bruno^a ; ^b ; ^{bruno.1@osu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Positive allosteric modulators ; Choline ; Microelectrode array ; Prefrontal cortex ; Glutamate ; α7 receptors

刊名：Neuropharmacology

出版年：2016

9.In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator

作者：Alessandra Porcu^a ; Carla Lobina^b ; Daniela Giunta^c ; Maurizio Solinas^c ; Claudia Mugnaini^d ; M. Paola Castelli^a ; ^{castelli@unica.it" class="auth_mail" title="E-mail the corresponding author}

关键词：GABAB receptors ; Positive allosteric modulator ; GTPγS binding ; Baclofen-induced sedation/hypnosis

刊名：European Journal of Pharmacology

出版年：2016

10.Anticonvulsant effects of structurally diverse GABA_B positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model

作者：Jordan W. Brown^a ; ^{jordan.brown@abbvie.com" class="auth_mail" title="E-mail the corresponding author} ; Achim Moeller^b ; Martin Schmidt^b ; Sean C. Turner^b ; Volker Nimmrich^b ; Junli Ma^c ; Lynne E. Rueter^a ; Elizabeth van der Kam^b ; Min Zhang^a

关键词：GABAB ; Positive allosteric modulator ; Baclofen ; Anticonvulsant ; Audiogenic seizure ; DBA/2J

刊名：Neuropharmacology

出版年：2016

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