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中国地质文献-英文(19)	SpringerLink电子期刊(884)	NATURE电子期刊(8)	Elsevier电子期刊(12726)
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在“Elsevier电子期刊”中，命中：12,726条，耗时：0.2968572 秒

在所有数据库中总计命中：14,325条

1.Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells

作者：Qiwen Wang^a ; Chenyao Ma^a ; Yun Ma^a ; Xiang Li^a ; ^c ; ^{lixiang_8182@163.com} ; Yong Chen^a ; ^{achenyongmail@163.com} ; Jianwei Chen^a ; ^b

关键词：Xanthone ; Cytotoxic activity ; Multidrug resistant ; Structure-activity relationships

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies

作者：Dongmei Zhao^a ; ^{medchemzhao@163.com} ; Shizhen Zhao^a ; Liyu Zhao^a ; Xiangqian Zhang^a ; Peng Wei^a ; Chunchi Liu^a ; Chenzhou Hao^a ; Bin Sun^c ; Xin Su^b ; ^{suxin1966@163.com} ; Maosheng Cheng^a

关键词：Antifungal activity ; CYP51 ; Structure-activity relationship ; Azole antifungals

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Diversity selection, screening and quantitative structure-activity relationships of osmolyte-like additive effects on the thermal stability of a monoclonal antibody

作者：Olubukayo-Opeyemi Oyetayo^a ; ^{oyetayophdhbc@gmail.com} ; Oscar Mé ; ndez-Lucio^b ; Andreas Bender^b ; Hans Kiefer^a

关键词：mAb ; Monoclonal antibody ; MOE ; Molecular Operating Environment ; MDS ; Multi-dimensional scaling ; QSAR ; Quantitative structure&ndash ; activity relationship ; DSC ; Differential scanning calorimetry ; DSF ; Differential scanning fluorimetry ; DMSO ; Dimethyl sulfoxide ; NaOH ; Sodium hydroxide ; HCl ; Hydrochloric acid ; LOO-CV ; Leave-one-out cross-validation ; PCA ; Principal components analysis ; PLS ; Partial least squares ; TMAO ; Trimethylamine N-oxide ; Tm ; Melting temperature ; TS potency ; Thermal stabilization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

4.Design, synthesis and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

作者：Wei-Huang Zhou^a ; ^b ; Xi-Guo Xu^a ; ^b ; Jin Li^b ; Xiao Min^b ; Jian-Zhong Yao^b ; Guo-Qiang Dong^b ; Chun-Lin Zhuang^b ; ^{zclnathan@163.com} ; Zhen-Yuan Miao^b ; ^{miaozhenyuan@hotmail.com} ; Wan-Nian Zhang^a ; ^b ; ^{zhangwnk@hotmail.com}

关键词：p53-MDM2 ; Protein&ndash ; protein interaction ; Inhibitors ; Drug design ; Structure&ndash ; activity relationships ; Antiproliferative

刊名：Chinese Chemical Letters

出版年：2017

5.Structure-activity relationships and optimization of acyclic acylphloroglucinol analogues as novel antimicrobial agents

作者：Haibo Tan^a ; ¹ ; Hongxin Liu^a ; ^b ; ¹ ; Liyun Zhao^a ; ^c ; Yao Yuan^a ; ^c ; Bailin Li^a ; ^c ; Yueming Jiang^a ; Liang Gong^a ; ^{lianggong@scbg.ac.cn} ; Shengxiang Qiu^a ; ^{sxqiu@scbg.ac.cn}

关键词：Anti-MRSA ; Acylphloroglucinol ; Mechanism ; Structure-activity relationship

刊名：European Journal of Medicinal Chemistry

出版年：2017

6.Cytotoxic activity, apoptosis induction and structure-activity relationship of 8-OR-2-aryl-3,4-dihydroisoquinolin-2-ium salts as promising anticancer agents

作者：Fang-Jun Cao¹ ; Li-Fei Zhu¹ ; Qian Kuang ; Xing-Qiang Li ; Bo-Hang Zhou ; Xin-Juan Yang ; ^{yxjsn2@163.com} ; Le Zhou ; ^{zhoulechem@nwsuaf.edu.cn}

关键词：Isoquinoline ; Benzo[c]phenanthridine alkaloid ; Cytotoxicity ; Apoptosis induction ; Structure&ndash ; activity relationship

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

7.The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum

作者：Shuzhen Yang^a ; ^{yszhen@mail.hzau.edu.cn} ; Jie Zhou^a ; ^{631458741@qq.com} ; Dongmei Li^b ; ^{daisyallen2008@163.com} ; Chunyu Shang^a ; ^{897080430@qq.com} ; Litao Peng^a ; ^{penglt12@mail.hzau.edu.cn} ; Siyi Pan^a ; ^{pansiyi@mail.hzau.edu.cn}

关键词：5 ; 7-Dihydroxyflavonoids ; P. italicum ; Spore germination ; Respiration ; Structure-activity relationship

刊名：Food Chemistry

出版年：2017

8.An orientation sensitive approach in biomolecule interaction quantitative structure-activity relationship modeling and its application in ion-exchange chromatography

作者：Jö ; rg Kittelmann^a ; Katharina M.H. Lang^a ; Marcel Ottens^b ; Jü ; rgen Hubbuch^a ; ^{Juergen.Hubbuch@kit.edu}

关键词：Quantitative structure&ndash ; activity relationship (QSAR) ; Predictive modeling ; Ion-exchange chromatography ; Binding orientation ; Retention modeling ; Isotherm

刊名：Journal of Chromatography A

出版年：2017

9.A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A

作者：William A. Harrell Jr.^a ; ^d ; Rebecca C. Vieira^a ; ^e ; Susan M. Ensel^b ; Vicki Montgomery^a ; Rebecca Guernieri^a ; Vanessa S. Eccard^a ; ^f ; Yvette Campbell^a ; Virginia Roxas-Duncan^a ; ^g ; John H. Cardellina II^a ; ^h ; Robert P. Webb^a ; ^{robert.p.webb6.civ@mail.mil} ; Leonard A. Smith^c

关键词：BoNTs ; botulinum neurotoxins ; BoNT/A ; botulinum neurotoxin serotype A ; HC ; heavy chain ; LC ; light chain ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptor ; SNAP-25 ; 25 ; kDa synaptosomal-associated protein ; BIG-IV ; Botulism Immune Globulin Intravenous (Human) ; SAR ; structure-activity relationship ; IC50 ; 50% inhibitory concentration ; MPNHDA ; mouse phrenic nerve hemidiaphragm assay

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

10.Identification of novel peptides from 3 to 10 kDa pine nut (Pinus koraiensis) meal protein, with an exploration of the relationship between their antioxidant activities and secondary structure

作者：Ruiwen Yang^a ; Xingfang Li^a ; Songyi Lin^a ; ^b ; ^{linsongyi730@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zuoming Zhang^c ; ; Feng Chen^d

关键词：Pine nut meal protein ; Antioxidant peptides ; Pulsed electric field (PEF) ; Circular dichroism (CD) ; Activity-structure relationship ; Random coil

刊名：Food Chemistry

出版年：2017

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