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在“Elsevier电子期刊”中，命中：1,260条，耗时：0.0169966 秒

在所有数据库中总计命中：1,712条

1.The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT_1A receptor over α₁-adrenoceptor and D₂-like receptor subtypes

作者：Fabio Del Bello^a ; ¹ ; Alessandro Bonifazi^a ; ^b ; ¹ ; Mario Giannella^a ; Gianfabio Giorgioni^a ; Alessandro Piergentili^a ; Riccardo Petrelli^a ; Carlo Cifani^a ; Maria Vittoria Micioni Di Bonaventura^a ; Thomas M. Keck^b ; ^c ; ^d ; Angelica Mazzolari^e ; Giulio Vistoli^e ; Antonio Cilia^f ; Elena Poggesi^f ; Rosanna Matucci^g ; Wilma Quaglia^a ; ^{wilma.quaglia@unicam.it}

关键词：5-HT1A receptor ; α1-Adrenoceptor subtypes ; D2-like receptor subtypes ; Selective 5-HT1A receptor agonists ; Docking studies ; Anxiolytic effect

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Synthesis, crystal structure, biological evaluation, and molecular docking studies of quinoline-arylpiperazine derivative as potent α_1A-adrenoceptor antagonist

作者：Wei Xu^a ; Renwang Jiang^a ; ^{rwjiang2008@126.com} ; Mu Yuan^b ; ^{mryuanmu838@sina.com}

关键词：α1-Adrenoceptor ; Quinoline-arylpiperazine ; X-ray crystallography ; Molecular docking ; Pharmacophoric model

刊名：Journal of Molecular Structure

出版年：2017

3.A benzo[b]thiophene-based selective type 4 S1P receptor agonist

作者：Wooyoung Hur^a ; ¹ ; Hugh Rosen^b ; Nathanael S. Gray^a ; ^{Nathanael_Gray@dfci.harvard.edu}

关键词：Sphingosine-1-phosphate ; S1P receptor ; S1PR4 ; S1P4 ; Selective agonist

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Subtype Selectivity of Tets on GABA-A Receptors

刊名：Biophysical Journal

出版年：2017

5.Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes

作者：Xiaofeng Ma^a ; Hodney Lubin^a ; Enikő Ioja^b ; Orsolya Ké ; kesi^b ; Á ; gnes Simon^b ; Á ; gota Apá ; ti^c ; Tamá ; s I. Orbá ; n^d ; Lá ; szló ; Hé ; ja^b ; Julianna Kardos^b ; ^{kardos.julianna@ttk.mta.hu" class="auth_mail" title="E-mail the corresponding author} ; Istvá ; n E. Markó ; ^a ; ^{istvan.marko@uclouvain.be" class="auth_mail" title="E-mail the corresponding author}

关键词：Azaspiro[4.5]decane scaffold ; γ-Aminobutyric acid (GABA) ; GABA transporter subtype GAT2 (slc6a13) ; ω-Amino acid selectivity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Discovery of highly potent dual EP₂ and EP₃ agonists with subtype selectivity

作者：Akihiro Kinoshita^a ; ^{ak.kinoshita@ono.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Masato Higashino^a ; Yoshiyuki Aratani^a ; Akito Kakuuchi^a ; Hidekazu Matsuya^b ; Kazuyuki Ohmoto^a ; ^{k.ohmoto@ono.co.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：Prostaglandin ; EP2 receptor ; EP3 receptor ; Dual agonist ; Underactive bladder

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Characterization of PCS1055, a novel muscarinic M₄ receptor antagonist

作者：Carrie H. Croy^b ; Wai Y. Chan^a ; ¹ ; Andrea M. Castetter^b ; Marla L. Watt^b ; ² ; Anne T. Quets^b ; Christian C. Felder^b ; ^{Felder@lilly.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Muscarinic M4 receptors ; Competitive antagonists ; PCS1055 ; Subtype selectivity

刊名：European Journal of Pharmacology

出版年：2016

8.Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype

作者：Carlo Matera^a ; Marta Quadri^a ; Miriam Sciaccaluga^b ; Diego Yuri Pomè ; ^a ; Francesca Fasoli^d ; ^e ; Marco De Amici^a ; Sergio Fucile^b ; ^c ; Cecilia Gotti^d ; ^e ; Clelia Dallanoce^a ; ^{clelia.dallanoce@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Giovanni Grazioso^a

关键词：Neuronal nicotinic acetylcholine receptors ; Molecular modeling ; Design ; Anabaseine-related derivatives ; α3β4 nicotinic ligands ; Binding affinity ; Functional activity/selectivity

刊名：European Journal of Medicinal Chemistry

出版年：2016

9.Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

作者：Jessica Sallander^a ; Charlotta Wallinder^b ; Anders Hallberg^b ; Johan Å ; qvist^a ; Hugo Gutié ; rrez-de-Terá ; n^a ; ^{hugo.gutierrez@icm.uu.se" class="auth_mail" title="E-mail the corresponding author}

关键词：AngII ; angiotensin II ; AT1 ; angiotensin II receptor type 1 ; AT2 ; angiotensin II receptor type 2 ; GPCR ; G-protein coupled receptor ; TM ; transmembrane domain ; EL ; extracellular loop ; IL ; intracellular loop ; MD ; molecular dynamics ; NMR ; nuclear magnetic resonance

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Molecular basis for high affinity and selectivity of peptide antagonist, Bantag-1, for the orphan BB₃ receptor

作者：Taichi Nakamura¹ ; Irene Ramos-Á ; lvarez¹ ; Tatiana Iordanskaia ; Paola Moreno ; Samuel A. Mantey ; R.T. Jensen ; ^{robertj@bdg10.niddk.nih.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：Bantag-1 ; Boc-Phe-His-4-amino-5-cyclohexyl-24 ; 5-trideoxypentonyl-Leu-(3-dimethylamino) benzylamide N-methylammonium trifluoroacetate ; BB3 receptor antagonist ; BB3 receptor or BB3 ; bombesin receptor subtype-3 ; BB3&lowast ; receptor or BB3&lowast ; His294 in BB3 receptor substituted for by Arg288 in comparable position of BB2 receptor to increase expression level ; Bn ; bombesin ; BnR ; bombesin receptor ; CHOP ; polyoma large T antigen-expressing Chinese hamster ovary cells ; DMEM ; Dulbecco&rsquo ; s mini

刊名：Biochemical Pharmacology

出版年：2016

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