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Elsevier电子期刊(263)
在“
Elsevier电子期刊
”中,
命中:
263
条,耗时:小于0.01 秒
在所有数据库中总计命中:
263
条
1.
Studies of
TAK1
-centered polypharmacology with novel covalent TAK1 inhibitors
作者:
Li Tan
a
;
b
;
j
;
Deepak Gurbani
c
;
j
;
Ellen L. Weisberg
e
;
f
;
j
;
Douglas S. Jones
g
;
h
;
j
;
Suman Rao
a
;
b
;
g
;
William D. Singer
c
;
d
;
Faviola M. Bernard
c
;
d
;
Samar Mowafy
a
;
b
;
i
;
Annie Jenney
g
;
Guangyan Du
a
;
b
;
Atsushi Nonami
e
;
f
;
James D. Griffin
e
;
f
;
Douglas A. Lauffenburger
h
;
Kenneth D. Westover
c
;
d
;
Kenneth.Westover@UTSouthwestern.edu
;
Peter K. Sorger
g
;
Peter_Sorger@hms.harvard.edu
;
Nathanael S. Gray
a
;
b
;
Nathanael_Gray@dfci.harvard.edu
关键词:
TAK1
;
Polypharmacology
;
Multitarget
;
Cancer
;
Cytokine secretion
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
2.
Structure-guided development of covalent
TAK1
inhibitors
作者:
Li Tan
a
;
b
;
j
;
Deepak Gurbani
c
;
d
;
j
;
Ellen L. Weisberg
e
;
f
;
John C. Hunter
c
;
d
;
Lianbo Li
c
;
d
;
Douglas S. Jones
g
;
h
;
Scott B. Ficarro
a
;
b
;
Samar Mowafy
a
;
b
;
i
;
Chun-Pong Tam
a
;
b
;
Suman Rao
a
;
b
;
g
;
Guangyan Du
a
;
b
;
James D. Griffin
e
;
f
;
Peter K. Sorger
g
;
Jarrod A. Marto
a
;
b
;
Kenneth D. Westover
c
;
d
;
Kenneth.Westover@UTSouthwestern.edu
;
Nathanael S. Gray
a
;
b
;
Nathanael_Gray@dfci.harvard.edu
关键词:
Structure-based design
;
TAK1
kinase inhibitors
;
Covalent inhibitors
;
2
;
4-Disubstituted pyrimidine
;
Structure-activity relationship
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
3.
Loss of TRADD attenuates pressure overload-induced cardiac hypertrophy through regulating
TAK1
/P38 MAPK signalling in mice
作者:
Lianpin Wu
a
;
b
;
1
;
Zhiyong Cao
c
;
1
;
Ling Ji
d
;
Liqin Mei
e
;
Qike Jin
b
;
Jingjing Zeng
b
;
Jiafeng Lin
b
;
Maoping Chu
b
;
Lei Li
b
;
lileiii@yahoo.com
;
Xiangjun Yang
a
;
th.reestonee@gmail.com
关键词:
TAK1
;
Pressure overload
;
TRADD
;
Cardiac hypertrophy
刊名:Biochemical and Biophysical Research Communications
出版年:2017
4.
Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries
作者:
Takaaki Miura
a
;
miuratka@chugai-pharm.co.jp
;
Atsushi Matsuo
b
;
Terushige Muraoka
b
;
Mitsuaki Ide
b
;
Kenji Morikami
b
;
Takayuki Kamikawa
a
;
Masamichi Nishihara
b
;
Hirotaka Kashiwagi
b
关键词:
TAK1
;
Chemogenomic approach
;
Selective Type I inhibitor
;
Biophysical screening
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
5.
Corrigendum to “Modification of
TAK1
by O-linked N-acetylglucosamine facilitates TAK1 activation and promotes M1 macrophage polarization” [Cell Signal. 28 (11) (2016) 1742-1752]
作者:
Dongmei Zhang
a
;
c
;
1
;
Zhiwei Xu
b
;
c
;
1
;
Tao Tao
b
;
c
;
Xiaojuan Liu
a
;
c
;
Xiaolei Sun
a
;
c
;
Yuhong Ji
b
;
Lijian Han
c
;
Huiyuan Qiu
c
;
Guizhou Zhu
b
;
Yifen Shen
b
;
Liang Zhu
c
;
Aiguo Shen
c
;
d
;
shag@ntu.edu.cn
刊名:Cellular Signalling
出版年:2017
6.
Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (
TAK1
) inhibitor by structure based drug design (SBDD)
作者:
Terushige Muraoka
a
;
muraokatrs@chugai-pharm.co.jp" class="auth_mail" title="E-mail the corresponding author
;
Mitsuaki Ide
a
;
Kenji Morikami
a
;
Machiko Irie
b
;
Mitsuaki Nakamura
b
;
Takaaki Miura
b
;
Takayuki Kamikawa
b
;
Masamichi Nishihara
a
;
Hirotaka Kashiwagi
a
关键词:
TAK1
;
SBDD
;
Inhibitor
;
Kinase selectivity
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
7.
TAK1
knockdown enhances lipopolysaccharide-induced secretion of proinflammatory cytokines in myeloid cells via unleashing MEKK3 activity
作者:
Kun Li
a
;
b
;
Meichen Wang
c
;
Yaping Hu
a
;
Na Xu
a
;
Qin Yu
d
;
Qinfu Wang
a
;
qinfuwang@126.com
关键词:
TGF-β activating protein kinase 1 (
TAK1
)
;
Lipopolysaccharide (LPS)
;
Toll-like receptor 4 (TLR4)
;
Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MEKK3)
;
Myeloid cell
刊名:Cellular Immunology
出版年:2016
8.
Lack of
TAK1
in dendritic cells inhibits the contact hypersensitivity response induced by trichloroethylene in local lymph node assay
作者:
Pan Yao
;
Chu Hongqian
;
Meng Qinghe
;
Shang Lanqin
;
Jiang Jianjun
;
Yang Xiaohua
;
Wei Xuetao
;
Hao Weidong
;
whao@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
TCE
;
trichloroethylene
;
CHS
;
contact hypersensitivity
;
TAK1
;
transforming growth factor-β activated kinase-1
;
DC
;
dendritic cell
;
LLNA
;
local lymph node assay
;
ACD
;
allergic contact dermatitis
;
DNFB
;
2
;
4-dinirofluorobenzene
刊名:Toxicology and Applied Pharmacology
出版年:2016
9.
IL-1β-induced MCP-1 expression and secretion of human dental pulp cells is related to
TAK1
, MEK/ERK, and PI3K/Akt signaling pathways
作者:
Mei-Chi Chang
a
;
Yi-Ling Tsai
b
;
1
;
Hsiao-Hua Chang
b
;
1
;
hhchang.pedo@gmail.com" class="auth_mail" title="E-mail the corresponding author
;
Sheng-Yang Lee
c
;
Ming-Shu Lee
b
;
Chun-Wei Chang
c
;
Chiu-Po Chan
d
;
Chien-Yang Yeh
b
;
Ru-Hsiu Cheng
c
;
Jiiang-Huei Jeng
b
;
jhjeng@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author
关键词:
Cyclooxygenase
;
Inflammation
;
Interleukin-1β
;
MCP-1
;
MEK/ERK
;
PI3K/Akt
;
Pulp
;
Signal transduction
;
TAK1
刊名:Archives of Oral Biology
出版年:2016
10.
Tetrandrine regulates hepatic stellate cell activation via
TAK1
and NF-κB signaling
作者:
Xia Li
a
;
1
;
Quan Jin
a
;
1
;
Yan-Ling Wu
a
;
Peng Sun
b
;
Shuang Jiang
a
;
Yu Zhang
a
;
De-Quan Zhang
a
;
Yu-Jing Zhang
a
;
Li-Hua Lian
a
;
lihualian@ymail.com" class="auth_mail" title="E-mail the corresponding author
;
Ji-Xing Nan
a
;
jxnan@ybu.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
α-SMA
;
α-smooth muscle actin
;
ECM
;
extracellular matrix
;
ERK
;
extracellular signal-regulated kinases
;
FADD
;
Fas-associated death domain protein
;
HSC
;
hepatic stellate cell
;
JNK
;
c-Jun N-terminal kinase
;
MAPK
;
mitogen-activated protein kinases
;
NF-κB
;
nuclear factor-κB
;
TNF-α
;
tumor necrosis factor-α
;
TAK1
;
TGF-β&ndash
;
activated kinase-1
;
TRADD
;
TNFR-1-associated death domain
刊名:International Immunopharmacology
出版年:2016
1
2
3
4
5
6
7
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