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Wiley电子期刊(14)
NATURE电子期刊(7)
ACS电子期刊(213)
SpringerLink电子期刊(256)
Elsevier电子期刊(930)
在“
Elsevier电子期刊
”中,
命中:
930
条,耗时:0.0239899 秒
在所有数据库中总计命中:
1,420
条
1.
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid
derivative
s active as novel potent allosteric inhibitors of protein
tyrosine
phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents
作者:
Rosaria Ottanà
;
a
;
Paolo Paoli
b
;
Alexandra Naß
;
c
;
Giulia Lori
b
;
Venera Cardile
d
;
Ilenia Adornato
a
;
Archimede Rotondo
e
;
Adriana Carol Eleonora Graziano
d
;
Gerhard Wolber
c
;
Rosanna Maccari
a
;
rmaccari@unime.it
关键词:
Protein
tyrosine
phosphatases
;
Enzyme inhibitors
;
Insulinomimetic effects
;
Anti-inflammatory activity
;
Molecular docking
;
5-Arylidene-4-thiazolidinone
derivative
s
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
A tetramic acid
derivative
with protein
tyrosine
phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.
作者:
Wilmar Maarisit
a
;
b
;
Hiroyuki Yamazaki
a
;
yamazaki@tohoku-mpu.ac.jp
;
Syu-ichi Kanno
a
;
Ayako Tomizawa
a
;
Henki Rotinsulu
c
;
Defny S. Wewengkang
c
;
Deiske A. Sumilat
b
;
Kazuyo Ukai
a
;
Magie M. Kapojos
d
;
Michio Namikoshi
a
关键词:
Tetramic acid
;
Melophlin
;
Sarasinoside
;
Marine sponge
;
Petrosia sp.
;
Protein
tyrosine
phosphatase 1B
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
3.
Design, synthesis and biological evaluation of indolin-2-one-based
derivative
s as potent, selective and efficacious inhibitors of FMS-like
tyrosine
kinase3 (FLT3)
作者:
Fei Ma
a
;
Peng Liu
a
;
Min Lei
a
;
Jian Liu
b
;
liujian623@njucm.edu.cn
;
Hongtao Wang
c
;
Shaohua Zhao
c
;
Lihong Hu
a
;
b
;
lhhu@simm.ac.cn
关键词:
Indolin-2-one
derivative
s
;
FLT3 inhibitors
;
Structure-activity relationships (SARs)
;
Acute myeloid leukemia (AML)
;
In vivo study
刊名:European Journal of Medicinal Chemistry
出版年:2017
4.
Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid
derivative
s as protein
tyrosine
phosphatase 1B inhibitors
作者:
Sujay Basu
;
sujay.basu@advinus.com
;
Philip Prathipati
;
Sachin Thorat
;
Shariq Ansari
;
Meena Patel
;
Vaibhav Jain
;
Ramana R. Jinugu
;
Sanjay Niranjan
;
Siddhartha De
;
Satyanarayana Reddy
关键词:
Protein
tyrosine
phosphatase 1B
;
Pharmacophore
;
Permeability
;
Hydrophobic
;
Oxadiazole
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
5.
Inhibition kinetics and molecular simulation of p-substituted cinnamic acid
derivative
s on tyrosinase
作者:
Yi Cui
a
;
Yong-Hua Hu
a
;
Feng Yu
a
;
Jing Zheng
a
;
Lin-Shan Chen
a
;
Qing-Xi Chen
a
;
b
;
Qin Wang
a
;
qwang@xmu.edu.cn
关键词:
4-CCA
;
4-chlorocinnamic acid
;
4-ECA
;
4-ethoxycinnamic acid
;
4-NCA
;
4-nitrocinnamic acid
;
DMSO
;
dimethyl-sulfoxide
;
L-Tyr
;
L-
tyrosine
;
L-DOPA
;
L-3
;
4-Dihydroxyphenylalanine
;
Km
;
Michaelis-Menten constant
;
KI
;
equilibrium constant of the inhibitor combining with the free enzyme
;
IC50
;
inhibitor concentration leading to a 50% loss of activity
刊名:International Journal of Biological Macromolecules
出版年:2017
6.
Synthesis and antiproliferative activity of monocationic arylthiophene
derivative
s
作者:
Mohamed A. Ismail
a
;
b
;
ismail_158@yahoo.com
;
mismail@mans.edu.eg
;
Magdy M. Youssef
a
;
b
;
Reem K. Arafa
c
;
Shar S. Al-Shihry
a
;
Wael M. El-Sayed
d
;
waelelhalawany@hotmail.com
;
wael_farag@sci.asu.edu.eg
关键词:
Monocationic arylthiophenes
;
Suzuki coupling
;
Antiproliferative activity
;
DNA affinity
;
tyrosine
kinase inhibition
刊名:European Journal of Medicinal Chemistry
出版年:2017
7.
Design and discovery of 4-anilinoquinazoline-urea
derivative
s as dual TK inhibitors of EGFR and VEGFR-2
作者:
Hai-Qi Zhang
1
;
Fei-Hu Gong
1
;
Ji-Qing Ye
;
Chi Zhang
;
Xiao-Hong Yue
;
Chuan-Gui Li
;
Yun-Gen Xu
;
Li-Ping Sun
关键词:
4-Anilinoquinazoline-urea
;
EGFR
;
VEGFR-2
;
Tyrosine
kinase inhibitor
;
Antitumor
刊名:European Journal of Medicinal Chemistry
出版年:2017
8.
Structural optimization of diphenylpyrimidine
derivative
s (DPPYs) as potent Bruton's
tyrosine
kinase (BTK) inhibitors with improved activity toward B leukemia cell lines
作者:
Dan Zhao
a
;
Shanshan Huang
a
;
Menghua Qu
a
;
Changyuan Wang
a
;
Zhihao Liu
a
;
Zhen Li
a
;
Jinyong Peng
a
;
Kexin Liu
a
;
Yanxia Li
b
;
Xiaodong Ma
a
;
xiaodong.ma@139.com
;
Xiaohong Shu
a
;
xiaohong_shu@dmu.edu.cn
关键词:
Leukemia
;
BTK
;
Pyrimidine
;
Synthesis
;
Inhibitor
刊名:European Journal of Medicinal Chemistry
出版年:2017
9.
Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine
derivative
inhibitor at 1.70 Å resolution
作者:
Manish Kumar Thakur
a
;
b
;
Swarnakumari Birudukota
b
;
Srinivasan Swaminathan
b
;
Sivarama Krishna Battula
b
;
Sarvanan Vadivelu
b
;
Rajiv Tyagi
b
;
Ramachandraiah Gosu
a
;
b
;
ramachandraiah_gosu@jubilantbiosys.com
关键词:
PTK6
;
BRK
;
Tyrosine
kinase
;
Co-crystal structure
;
Dasatinib
;
Inhibitor
刊名:Biochemical and Biophysical Research Communications
出版年:2017
10.
Identification of new pyrrolo[2,3-d]pyrimidines as Src
tyrosine
kinase inhibitors in vitro active against Glioblastoma
作者:
Francesca Musumeci
a
;
1
;
Anna Lucia Fallacara
b
;
1
;
Chiara Brullo
a
;
Giancarlo Grossi
a
;
Lorenzo Botta
c
;
Pierpaolo Calandro
b
;
Mario Chiariello
d
;
Miroslava Kissova
e
;
Emmanuele Crespan
e
;
Giovanni Maga
e
;
Silvia Schenone
a
;
schensil@unige.it
关键词:
Pyrrolo-pyrimidines
;
Src
;
Glioblastoma
;
Kinase inhibitors
;
Small molecules
刊名:European Journal of Medicinal Chemistry
出版年:2017
1
2
3
4
5
6
7
8
9
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