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1.
Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus
作者:
Zongyang Mou
1
;
2
;
Thomas M. Hyde
3
;
4
;
5
;
Barbara K. Lipska
6
;
Keri Martinowich
3
;
4
;
Peter Wei
1
;
7
;
Chiew-Jen Ong
1
;
7
;
Lindsay A. Hunter
1
;
7
;
Gladys I. Palaguachi
1
;
7
;
Eva Morgun
1
;
2
;
Rujia Teng
1
;
Chen Lai
1
;
7
;
Tania A. Condarco
2
;
Andrew P. Demidowich
2
;
Amanda J. Krause
2
;
Leslie J. Marshall
8
;
Karin Haack
9
;
V. Saroja Voruganti
9
;
10
;
Shelley A. Cole
9
;
Nancy F. Butte
11
;
Anthony G. Comuzzie
9
;
Michael A. Nalls
12
;
Alan B. Zonderman
13
;
Andrew B. Singleton
12
;
Michele K. Evans
14
;
Bronwen Martin
15
;
Stuart Maudsley
16
;
17
;
18
;
Jack W. Tsao
2
;
7
;
19
;
Joel E. Kleinman
3
;
4
;
5
;
Jack A. Yanovski
2
;
Joan C. Han
1
;
2
;
20
;
21
;
jhan14@uthsc.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Mou et al. show that brain-derived neurotrophic factor (BDNF) rs12291063 minor C allele disrupts binding and transactivation by the transcriptional regulator
;
heterogeneous
nuclear
ribonucleoprotein
D0B
;
and it is associated with lower ventromedial hypothalamic BDNF expression and obesity. BDNF augmentation may be specifically beneficial for treating obesity in individuals with the CC genotype
刊名:Cell Reports
出版年:2015
1
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