设为首页
收藏本站
网站地图
|
English
|
公务邮箱
About the library
Background
History
Leadership
Organization
Readers' Guide
Opening Hours
Collections
Help Via Email
Publications
Electronic Information Resources
常用资源
电子图书
期刊论文
学位会议
外文资源
特色专题
内部出版物
Wiley电子期刊(10)
SpringerLink电子期刊(503)
Elsevier电子期刊(1798)
Springer电子图书(2)
NATURE电子期刊(16)
ACS电子期刊(170)
在“
Elsevier电子期刊
”中,
命中:
1,798
条,耗时:0.0809882 秒
在所有数据库中总计命中:
2,499
条
1.
Linker-switch approach towards new ATP
binding
site
inhibitor
s
of
DNA
gyrase B
作者:
Marko Jukič
a
;
Janez Ila&scaron
;
a
;
Matjaž Brvar
b
;
Danijel Kikelj
a
;
Jožko Cesar
a
;
Marko Anderluh
a
;
marko.anderluh@ffa.uni-lj.si
关键词:
Antibiotics
;
Antibacterials
;
Inhibitor
;
DNA
gyrase B
;
ATP
binding
site
;
Pyrrole-2-carboxamides
;
Structure-based drug design
;
Ligand-based drug design
刊名:European Journal
of
Medicinal Chemistry
出版年:2017
2.
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity
作者:
Xin Luo
1
;
2
;
3
;
8
;
Keun Woo Ryu
1
;
2
;
3
;
8
;
Dae-Seok Kim
1
;
2
;
Tulip Nandu
1
;
2
;
Carlos J. Medina
4
;
Rebecca Gupte
1
;
2
;
Bryan A. Gibson
1
;
2
;
5
;
Raymond E. Soccio
4
;
Yonghao Yu
6
;
Rana K. Gupta
7
;
W. Lee Kraus
1
;
2
;
3
;
9
;
lee.kraus@utsouthwestern.edu
关键词:
adipogenesis
;
C/EBPβ
;
DNA
binding
;
gene expression
;
PARP
inhibitor
;
PARP-1
;
PARylation
;
poly(ADP-ribose)
;
transcription
刊名:Molecular Cell
出版年:2017
3.
Design, synthesis and biological evaluation
of
4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel
DNA
gyrase
inhibitor
s
作者:
Tihomir Toma&scaron
;
ič
a
;
tihomir.tomasic@ffa.uni-lj.si
;
Matic Mirt
a
;
Michaela Barančoková
;
a
;
Janez Ila&scaron
;
a
;
Nace Zidar
a
;
Pä
;
ivi Tammela
b
;
Danijel Kikelj
a
关键词:
Antibacterial
;
DNA
gyrase
;
Docking
;
Inhibitor
;
Thiazole
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
4.
Reversal
of
platinum drug resistance by the histone deacetylase
inhibitor
belinostat
作者:
Kenneth Kin-Wah To
a
;
kennethto@cuhk.edu.hk
;
Wing-Sum Tong
a
;
Li-wu Fu
b
关键词:
ABC
;
ATP-
binding
cassette
;
CFDA
;
carboxy-2&rsquo
;
7&rsquo
;
-dichlor
of
luorescein diacetate
;
MDR
;
multidrug resistance
;
NC2
;
negative c
of
actor 2
;
NSCLC
;
non-small cell lung cancer
;
Pt
;
platinum
;
SRB
;
sulforhodamine B
刊名:Lung Cancer
出版年:2017
5.
Rational design, synthesis and in vitro evaluation
of
novel exo-methylene butyrolactone salicyloylamide as NF-κB
inhibitor
作者:
Kulrawee Sidthipong
a
;
Jun Ma
b
;
Wei Lin Yu
b
;
Yan Feng Wang
b
;
Susumu Kobayashi
c
;
Satoshi Kishino
d
;
Naoki Koide
e
;
Takashi Yokochi
e
;
Kuniki Kato
a
;
Shoshiro Okada
f
;
Kazuo Umezawa
a
;
umezawa@aichi-med-u.ac.jp
关键词:
(&minus
;
)-DHMEQ
;
Cysteine
;
NF-κB
;
α-Exomethylene-γ-lactone
;
Bioconjugate
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
6.
13-Ethylberberine reduces HMGB1 release through AMPK activation in LPS-activated RAW264.7 cells and protects endotoxemic mice from organ damage
作者:
Dong Ung Lee
c
;
1
;
Young Shin Ko
a
;
1
;
Hye Jung Kim
a
;
b
;
Ki Churl Chang
a
;
b
;
kcchang@gnu.kr
关键词:
BBR
;
berberine
;
CLP
;
cecal ligation and puncture
;
HMGB1
;
high mobility group box 1
;
HO-1
;
heme oxygenase-1
;
iNOS
;
inducible nitric oxide synthase
;
LPS
;
lipopolysaccharide
;
NF-κB
;
Nuclear factor kappa B
;
NO
;
nitric oxide
;
siRNA
;
small interfering RNA
;
H&E
;
hematoxylin and eosin
;
PCNA
;
proliferating cell nuclear antigen
;
DMEM
;
dulbecco&rsquo
;
s modified eagle&rsquo
;
s medium
;
FBS
;
fatal bovine serum
;
AMPK
;
AMP-activated protein kinase
;
13-EBR
;
13-ethylberberine
;
TNF-α
;
tumor necrosis factor-alpha
;
I
刊名:Biomedicine & Pharmacotherapy
出版年:2017
7.
Recent progress in the development
of
protein-protein interaction
inhibitor
s targeting androgen receptor-coactivator
binding
in prostate cancer
作者:
Eric Biron
a
;
b
;
eric.biron@pha.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
;
Franç
;
ois Bé
;
dard
a
;
b
关键词:
AB
;
Sandrogen-
binding
site
;
AF
;
activation function
;
AR
;
androgen receptor
;
ARA
;
androgen receptor-associated protein
;
ARE
;
androgen-responsive elements
;
BF3
;
binding
function 3
;
CBI
;
coactivator
binding
inhibitor
;
CBP
;
CREB-
binding
protein
;
CPRC
;
castration-resistant prostate cancer
;
CYP
;
cytochrome P450
;
DBD
;
DNA
-
binding
domain
;
DHT
;
5α-dihydrotestosterone
;
ER
;
estrogen receptor
;
FP
;
fluorescence polarization
;
GRIP1
;
glutamate receptor interacting protein 1
;
LBD
;
ligand-
binding
domain
;
NLS
;
n
刊名:Journal
of
Steroid Biochemistry and Molecular Biology
出版年:2016
8.
Discovery
of
selective
inhibitor
s
of
tyrosyl-
DNA
phosphodiesterase 2 by targeting the enzyme DNA-
binding
cleft
作者:
Bradley R. Kossmann
a
;
Monica Abdelmalak
b
;
Sophia Lopez
b
;
Gabrielle Tender
b
;
Chunli Yan
a
;
Yves Pommier
b
;
Christophe Marchand
b
;
marchanc@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
;
Ivaylo Ivanov
a
;
iivanov@gsu.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Tyrosyl-
DNA
phosphodiesterase 2
;
TDP2
;
Inhibitor
;
Virtual screening
;
Rational drug design
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
9.
Inhibition
of
c-Rel
DNA
binding
is critical for the anti-inflammatory effects
of
novel PIKfyve
inhibitor
作者:
Masaomi Terajima
;
masaomi.terajima@astellas.com" class="auth_mail" title="E-mail the corresponding author
;
Yoko Kaneko-Kobayashi
;
Naoto Nakamura
;
Masatoshi Yuri
;
Masashi Hiramoto
;
Masanori Naitou
;
Kazuyuki Hattori
;
Hiroyuki Yokota
;
Hidekazu Mizuhara
;
Yasuyuki Higashi
关键词:
AIA
;
adjuvant-induced arthritis
;
DC
;
dendritic cell
;
DMF
;
N
;
N-dimethylformamide
;
IRF
;
interferon regulatory factor
;
MALDI-T
OF
MS
;
MALDI-T
OF
mass spectrometry
;
MDP
;
muramyldipeptide
;
PI
;
phosphoinositide
;
Poly(I
;
C)
;
polyinosinic-polycytidylic acid
;
TNP
;
2
4 ;
6-trinitrophenol
刊名:European Journal
of
Pharmacology
出版年:2016
10.
Synthesis and antiproliferative activity
of
9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent
DNA
-
binding
ligands and topoisomerase II
inhibitor
s
作者:
Wei Zhang
a
;
b
;
c
;
Bin Zhang
c
;
Wei Zhang
b
;
c
;
Ti Yang
a
;
Ning Wang
a
;
b
;
Chunmei Gao
a
;
b
;
chunmeigao@sz.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Chunyan Tan
b
;
d
;
Hongxia Liu
b
;
Yuyang Jiang
a
;
b
;
d
;
jiangyy@sz.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
Acridine derivatives
;
Topoisomerase II
inhibitor
;
Antiproliferative activity
;
DNA
damage
刊名:European Journal
of
Medicinal Chemistry
出版年:2016
1
2
3
4
5
6
7
8
9
按检索点细分(1798)
题名(39)
关键词(59)
文摘(1491)
按出版年细分(1798)
2027年及以后(65)
2017年(6)
2016年(49)
2015年(18)
2013年(95)
2012年(114)
2011年(119)
2010年(80)
2009年(78)
2008年(126)
2007年(96)
2006年(93)
2005年(95)
2004年(89)
2003年(89)
2002年(78)
2001年(75)
2000年(87)
2000年及以前(346)
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via
email
.