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在“
Elsevier电子期刊
”中,
命中:
1,711
条,耗时:0.0419802 秒
在所有数据库中总计命中:
2,630
条
1.
Tyrosine Kinase and
Mammalian
Target
of
Rapamycin
Inhibitors in
the
Treatment
of
Advanced Renal Cell Carcinoma: Practical Clinical Implications
of
Pharmacologic Features
作者:
Rahul A. Parikh
1
;
Leonard J. Appleman
1
;
applemanlj@upmc.edu
;
Jan H. Beumer
2
;
Ewa Matczak
3
;
Edward Chu
1
关键词:
Decision-making
;
Kidney cancer
;
Management
;
Pharmacology
;
Target
ed
the
rapy
刊名:Clinical Genitourinary Cancer
出版年:2017
2.
Kinetic modelling
of
in vitro data
of
PI3K, mTOR1, PTEN enzymes and on-
target
inhibitors
Rapamycin
, BEZ235, and LY294002
作者:
Alexey Goltsov
a
;
a.goltsov@abertay.ac.uk
;
Ghassan Tashkandi
b
;
s1163633@exseed.ed.ac.uk
;
Simon P. Langdon
b
;
Simon.Langdon@ed.ac.uk
;
David J. Harrison
c
;
David.Harrison@st-andrews.ac.uk
;
James L. Bown
a
;
d
;
j.bown@abertay.ac.uk
关键词:
Kinetic modelling
;
PI3K
;
mTOR1
;
PTEN
;
Rapamycin
;
BEZ235
刊名:European Journal
of
Pharmaceutical Sciences
出版年:2017
3.
Rapamycin
inhibits mTOR/p70S6K activation in CA3 region
of
the
hippocampus
of
the
rat and impairs long term memory
作者:
D. Lana
a
;
J. Di Russo
b
;
T. Mello
c
;
G.L. Wenk
d
;
M.G. Giovannini
a
;
mariagrazia.giovannini@unifi.it
关键词:
ACQ
;
acquisition
;
ACh
;
acetylcholine
;
DMSO
;
dimethyl sulfoxide
;
IA
;
inhibitory avoidance
;
i.c.v.
;
intracerebroventricular
;
i.p.
;
intraperitoneal
;
mTOR
;
mammalian
Target
of
Rapamycin
;
mAChR
;
muscarinic acetylcholine receptors
;
mTORC1
2 ;
mammalian
Target
of
Rapamycin
Complex 1
2 ;
MEC
;
mecamylamine
;
nAChR
;
nicotinic acetylcholine receptors
;
p70S6K
;
p70S6Kinase
;
P-mTOR
;
phospho-mTOR
;
P-p70S6K
;
phospho-p70S6K
;
RAPA
;
rapamycin
;
SCOP
;
scopolamine
;
SEM
;
standard error
of
the
mean
刊名:Neurobiology
of
Learning and Memory
出版年:2017
4.
Rapamycin
inhibits
the
proliferation
of
endo
the
lial cells in hemangioma by blocking
the
mTOR-FABP4 pathway
作者:
Ying Wang
1
;
a
;
Jiarui Chen
1
;
a
;
Weiqing Tang
b
;
Yanping Zhang
a
;
Xiaoyan Li
a
;
chhshent@126.com
关键词:
HemECs
;
hemangioma derived endo
the
lial cells
;
HDVECs
;
human dermal microvascular endo
the
lial cells
;
ECs
;
endo
the
lial cells
;
VEGFA
;
vascular endo
the
lial growth factor A
;
mTOR
;
mammalian
target
of
rapamycin
;
HIF
;
hypoxia inducible factor
;
FABP4
;
fatty acid-binding protein4
刊名:Biomedicine & Pharmaco
the
rapy
出版年:2017
5.
New
the
rapeutic strategies for malignant pleural meso
the
lioma
作者:
Mara A. Bonelli
mara.bonelli@unipr.it
;
Claudia Fumarola
claudia.fumarola@unipr.it
;
Silvia La Monica
silvia.lamonica@unipr.it
;
Roberta Alfieri
;
roberta.alfieri@unipr.it
关键词:
AE
;
adverse event
;
CTLA-4
;
cytotoxic T-lymphocyte-associated antigen 4
;
EGFR
;
epidermal growth factor receptor
;
FAK
;
focal adhesion kinase
;
IGFR
;
insulin growth factor receptor
;
MPM
;
malignant pleural meso
the
lioma
;
MTD
;
maximum tolerated dose
;
mTOR
;
mammalian
target
of
rapamycin
;
NSCLC
;
non-small cell lung cancer
;
OS
;
overall survival
;
PD
;
progressive disease
;
PFS
;
progression free survival
;
PD-1
;
programmed death 1
;
PDL-1
;
programmed death ligand 1
;
PI3K
;
phosphatidylinositol 3-kinase
;
PR
;
part
刊名:Biochemical Pharmacology
出版年:2017
6.
The
cochaperone BAG3 coordinates protein syn
the
sis and autophagy under mechanical strain through spatial regulation
of
mTORC1
作者:
Barbara Kathage
a
;
Sebastian Gehlert
b
;
Anna Ulbricht
a
;
Laura Lü
;
decke
a
;
Victor E. Tapia
c
;
Zacharias Orfanos
a
;
Daniela Wenzel
d
;
Wilhelm Bloch
b
;
Rudolf Volkmer
c
;
Bernd K. Fleischmann
d
;
Dieter O. Fü
;
rst
a
;
& Jö
;
rg Hö
;
hfeld
a
;
hoehfeld@uni-bonn.de
关键词:
BAG3
;
BCL2-associated athanogene
;
mTOR
;
mammalian
target
of
rapamycin
;
mTORC1
;
mammalian
target
of
rapamycin
complex 1
;
TSC
;
tuberous sclerosis
;
CASA
;
chaperone-assisted selective autophagy
;
CMA
;
chaperone-mediated autophagy
;
RE
;
maximal eccentric resistance exercise
;
ES
;
electrical stimulation
;
MBP
;
maltose-binding protein
;
CBD
;
chitin-binding domain
刊名:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
出版年:2017
7.
Dual
target
ing
of
eIF4E by blocking MNK and mTOR pathways in leukemia
作者:
Ewa M. Kosciuczuk
a
;
b
;
ewa.kosciuczuk@northwestern.edu
;
Diana Saleiro
a
;
Leonidas C. Platanias
a
;
b
关键词:
Translation initiation
;
eIF4E
;
MNK
;
mTOR
;
Acute myeloid leukemia
刊名:Cytokine
出版年:2017
8.
The
Journey
of
the
Autophagosome through
Mammalian
Cell Organelles and Membranes
作者:
Diana Molino
;
Naï
;
ma Zemirli
;
Patrice Codogno
;
Etienne Morel
;
etienne.morel@inserm.fr
关键词:
ER
;
endoplasmic reticulum
;
ATG
;
autophagy-related gene
;
mTORC1
;
mammalian
target
of
rapamycin
complex 1
;
PI3KC3
;
class III PI3 kinase
;
PI3P
;
phosphatidyl-inositol-3-phosphate
;
COPs
;
coating proteins
;
SNAREs
;
small Rab GTPases
;
membrane fusion proteins
;
MAMs
;
mitochondria-associated membranes
;
ERGIC
;
ER-to-Golgi intermediate compartment
;
TGN
;
trans-Golgi network
;
PM
;
plasma membrane
;
LAP
;
LC3-associated phagocytosis
;
TSC
;
tuberous sclerosis complex
;
ROS
;
reactive oxygen species
;
ERS
;
ER stress
;
T
刊名:Journal
of
Molecular Biology
出版年:2017
9.
A 15-gene signature for prediction
of
colon cancer recurrence and prognosis based on SVM
作者:
Guangru Xu
1
;
Minghui Zhang
1
;
Hongxing Zhu
;
Jinhua Xu
;
wuwuuwgdg@aliyun.com
关键词:
TCGA
;
The
Cancer Genome Atlas
;
LIMMA
;
Linear Models for Microarray data
;
DEGs
;
differentially expressed genes
;
SVM
;
support vector machine
;
d-CEA
;
draining venous blood
;
GEO
;
Gene Expression Omnibus
;
RMA
;
Robust Multichip Average
;
RFE
;
recursive feature elimination
;
ROC
;
receiver operation characteristic
;
2D
;
two-dimensional
;
HES5
;
Hairy and enhancer
of
split 5
;
RHEB
;
Ras homolog enriched in brain
;
mTORC1
;
mammalian
target
of
rapamycin
complex 1
;
SRY
;
sex-determining region Y
刊名:Gene
出版年:2017
10.
Genomic Biomarkers
of
a Randomized Trial Comparing First-line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma
作者:
James J. Hsieh
a
;
hsiehj@mskcc.org
;
David Chen
b
;
Patricia I. Wang
a
;
Mahtab Marker
b
;
Almedina Redzematovic
a
;
Ying-Bei Chen
a
;
S. Duygu Selcuklu
a
;
Nils Weinhold
a
;
Nancy Bouvier
a
;
Kety H. Huberman
a
;
Umesh Bhanot
a
;
Michael S. Chevinsky
a
;
c
;
Parul Patel
b
;
Patrizia Pinciroli
a
;
d
;
Helen H. Won
a
;
Daoqi You
a
;
Agnes Viale
a
;
William Lee
a
;
A. Ari Hakimi
a
;
Michael F. Berger
a
;
Nicholas D. Socci
a
;
Emily H. Cheng
a
;
Jennifer Knox
e
;
Martin H. Voss
a
;
Maurizio Voi
b
;
Robert J. Motzer
a
关键词:
Genomic biomarker
;
Kidney cancer
;
Target
ed
the
rapy
;
Everolimus
;
Sunitinib
;
Tumor suppressor gene
;
PBRM1
;
SETD2
;
BAP1
;
KDM5C
刊名:European Urology
出版年:2017
1
2
3
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5
6
7
8
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