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内部出版物
Wiley电子期刊(3)
NATURE电子期刊(2)
ACS电子期刊(2)
SpringerLink电子期刊(102)
Elsevier电子期刊(237)
在“
Elsevier电子期刊
”中,
命中:
237
条,耗时:0.040974 秒
在所有数据库中总计命中:
346
条
1.
Cardiac activation-repolarization patterns and ion channel expression mapping in intact isolated normal human hearts
作者:
Tobias Opthof
;
PhD
*
;
&dagger
;
;
Carol Ann Remme
;
MD
;
PhD
*
;
Esther Jorge
;
DVM
;
PhD
&Dagger
;
;
Francisco Noriega
;
MD
&Dagger
;
;
Rob F. Wiegerinck
;
PhD
&Dagger
;
;
Arlin Tasiam
*
;
Leander Beekman
*
;
Jesus Alvarez-Garcia
;
MD
&Dagger
;
;
Cristian Munoz-Guijosa
;
MD
;
PhD
§
;
;
Ruben Coronel
;
MD
;
PhD
*
;
¶
;
;
rubencoronel@gmail.com
;
Juan Cinca
;
MD
;
PhD
&Dagger
;
关键词:
Human heart
;
Repolarization pattern
;
Activation&ndash
;
recovery interval
;
Activation pattern
;
mRNA expression levels
;
Kv7.1 protein
;
Cardiac ion channel
刊名:Heart Rhythm
出版年:2017
2.
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
作者:
Scott E. Wolkenberg
a
;
scott_wolkenberg@merck.com
;
M. Brad Nolt
a
;
Mark T. Bilodeau
a
;
B. Wesley Trotter
a
;
Peter J. Manley
a
;
Nathan R. Kett
a
;
Kausik K. Nanda
a
;
Zhicai Wu
a
;
Matthew J. Cato
b
;
Stefanie A. Kane
b
;
Laszlo Kiss
b
;
Robert H. Spencer
b
;
Jixin Wang
b
;
Joseph J. Lynch
c
;
Christopher P. Regan
c
;
Gary L. Stump
c
;
Bing Li
d
;
Rebecca White
d
;
Suzie Yeh
d
;
Christopher J. Dinsmore
a
;
Craig W. Lindsley
a
;
George D. Hartman
a
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
3.
Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-
rapid
delayed
rectifie
r K
+
current in human atrial myocytes
作者:
Huan Wang
a
;
Hong-fei Wang
b
;
Chen Wang
a
;
Yu-fang Chen
a
;
Rong Ma
a
;
Ji-zhou Xiang
a
;
Xin-ling Du
b
;
Qiang Tang
a
;
tangqiang_tjmu@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
Hesperetin (PubChem CID
;
72281)
;
Dimethyl sulfoxide (PubChem CID
;
679)
;
BAPTA-AM (PubChem CID
;
2293)
;
Flecainide (PubChem CID
;
3356)
;
Dapoxetine (PubChem CID
;
71353)
;
Maleimide (PubChem CID
;
10935)
;
Atropine (PubChem CID
;
174174)
;
Cadmium Dichloride (PubChem CID
;
24947)
;
Barium Dichloride (PubChem CID
;
25204)
;
Ketanserin (PubChem CID
;
3822)
;
Nicardipine (PubChem CID
;
4474)
刊名:European Journal of Pharmacology
出版年:2016
4.
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
作者:
Yihong Zhang
a
;
Charlotte K. Colenso
b
;
1
;
Aziza El Harchi
a
;
Hongwei Cheng
a
;
Harry J. Witchel
c
;
Chris E. Dempsey
b
;
C.Dempsey@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author
;
Jules C. Hancox
a
;
Jules.hancox@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author
关键词:
AF
;
atrial fibrillation
;
diLQTS
;
drug induced long QT syndrome
;
DEA
;
desethylamiodarone
;
HEK
;
human embryonic kidney
;
hERG
;
human-Ether-à
;
-go-go-Related Gene
;
IC50
;
half-maximal inhibitory concentration
;
IhERG
;
ionic current carried by hERG potassium channels
;
IKr
;
rapid
delayed
rectifie
r potassium current
;
IKs
;
slow
delayed
rectifie
r potassium current
;
LQTS
;
long QT syndrome
刊名:Biochemical Pharmacology
出版年:2016
5.
Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes
作者:
Stefan A. Mann
a
;
b
;
1
;
Mohammad Imtiaz
a
;
Annika Winbo
c
;
2
;
Annika Rydberg
c
;
Matthew D. Perry
a
;
b
;
Jean-Philippe Couderc
d
;
Bronislava Polonsky
d
;
Scott McNitt
d
;
Wojciech Zareba
d
;
Adam P. Hill
a
;
b
;
a.hill@victorchang.edu.au
;
Jamie I. Vandenberg
a
;
b
;
j.vandenberg@victorchang.edu.au
关键词:
LQTS
;
long-QT syndrome
;
VM
;
ventricular myocyte
;
APD
;
Action potential duration
;
IKr
;
rapid
ly activating
delayed
rectifie
r current
;
IKs
;
slowly activating
delayed
rectifie
r current
;
INaL
;
late (persistent) sodium current
;
ICaL
;
L-type calcium current
;
NCX
;
Sodium-calcium exchanger
;
NaK
;
Sodium-potassium pump
刊名:Journal of Molecular and Cellular Cardiology
出版年:2016
6.
The positive frequency-dependent electrophysiological effects of the I
Kur
inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation
作者:
John Ford
;
PhD
*
;
James Milnes
;
PhD
*
;
Said El Haou
;
PhD
*
;
Erich Wettwer
;
PhD
&dagger
;
;
Simone Loose
;
MD
&dagger
;
;
Klaus Matschke
;
MD
&Dagger
;
;
Benoit Tyl
;
MD
§
;
;
Patrick Round
;
MBBS
*
;
Ursula Ravens
;
MD
&dagger
;
;
ravens@rcs.urz.tu-dresden.de" class="auth_mail" title="E-mail the corresponding author
关键词:
AF
;
atrial fibrillation
;
ANOVA
;
analysis of variance
;
AP
;
action potential
;
APA
;
action potential amplitude
;
APD20
;
APD50
;
APD90
;
action potential duration at 20%
;
50%
;
and 90% of repolarization
;
cAF
;
chronic atrial fibrillation
;
DMSO
;
dimethyl sulfoxide
;
dV/dtmax
;
maximum upstroke velocity
;
ECG
;
electrocardiogram/electrocardiographic
;
ERP
;
effective refractory period
;
HR
;
heart rate
;
IKur
;
ultra-
rapid
ly activating
delayed
-
rectifie
r potassium current
;
pAF
;
paroxysmal atrial fibrillation
;
PLT20
刊名:Heart Rhythm
出版年:2016
7.
Proteolytic cleavage in the S1-S2 linker of the Kv1.5 channel does not affect channel function
作者:
Andrew Hogan-Cann
;
Wentao Li
;
Jun Guo
;
Tonghua Yang
;
Shetuan Zhang
;
shetuan.zhang@queensu.ca" class="auth_mail" title="E-mail the corresponding author
关键词:
CHX
;
Cycloheximide
;
co-IP
;
Co-immunoprecipitation
;
hERG
;
Human ether-a-go-go-related gene
;
IKur
;
The ultra-
rapid
ly activating
delayed
rectifie
r potassium current
;
PK
;
Proteinase K
刊名:Biochimica et Biophysica Acta (BBA)-Biomembranes
出版年:2016
8.
Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development
作者:
P. Morissette
;
pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author
;
C. Regan
;
K. Fitzgerald
;
P. Gerenser
;
J. Travis
;
S. Wang
;
P. Fanelli
;
F. Sannajust
关键词:
ANES GP
;
anesthetized guinea pig
;
AUC
;
area under the curve
;
CAVB
;
complete atrioventricular blockade
;
Cmax
;
maximal plasmatic concentration
;
ECG
;
electrocardiogram
;
EMw
;
electromechanical window
;
EMw-10
;
;
&minus
;
;
10% shortening of the EMw
;
GP
;
guinea pig
;
FDA
;
Food and Drug Administration
;
hERG
;
human Ether-a-go-go Related Gene
;
HR
;
heart rate
;
ICH
;
International Conference on Harmonization
;
IKr
;
rapid
ly-activating
delayed
rectifie
r potassium current
;
LVP
;
left ventricular pressure
;
N
刊名:Journal of Pharmacological and Toxicological Methods
出版年:2016
9.
Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes
作者:
Stefano Morotti
a
;
Andrew D. McCulloch
b
;
Donald M. Bers
a
;
Andrew G. Edwards
c
;
d
;
Eleonora Grandi
a
;
ele.grandi@gmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
ACh
;
acetylcholine
;
AF
;
atrial fibrillation
;
AP
;
action potential
;
APD
;
action potential duration
;
[Ca2
;
+]i
;
intracellular Ca2
;
+ concentration
;
CaMKII
;
Ca2
;
+/calmodulin-dependent protein kinase II
;
DAD
;
delayed
afterdepolarization
;
EAD
;
early afterdepolarization
;
Em
;
membrane potential
;
ICa
;
L-type Ca2
;
+ current
;
INa
;
Na+ current
;
IKr
;
delayed
rectifie
r K+ current
;
INCX
;
Na+/Ca2
;
+ exchanger current
;
ISO
;
isoproterenol
;
NCX
;
Na+/Ca2
;
+ exchanger
;
pAF
;
paroxysmal atria
刊名:Journal of Molecular and Cellular Cardiology
出版年:2016
10.
Channeling your inner ear potassium: K
+
channels in vestibular hair cells
作者:
Frances L. Meredith
a
;
Katherine J. Rennie
a
;
b
;
katie.rennie@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
K+ conductance
;
Type I hair cell
;
Type II hair cell
;
Calyx
;
Crista
;
Utricle
;
Saccule
刊名:Hearing Research
出版年:2016
1
2
3
4
5
6
7
8
9
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