设为首页
收藏本站
网站地图
|
English
|
公务邮箱
About the library
Background
History
Leadership
Organization
Readers' Guide
Opening Hours
Collections
Help Via Email
Publications
Electronic Information Resources
常用资源
电子图书
期刊论文
学位会议
外文资源
特色专题
内部出版物
Wiley电子期刊(13)
NATURE电子期刊(1)
ACS电子期刊(22)
SpringerLink电子期刊(575)
Elsevier电子期刊(554)
在“
Elsevier电子期刊
”中,
命中:
554
条,耗时:0.079962 秒
在所有数据库中总计命中:
1,165
条
1.
A simple and sensitive liquid chromatography-tandem mass spectrometry method for trans-ε-viniferin quantification in mouse
plasma
and its application to a pharmacokinetic study in mice
作者:
Jiseon Kim
a
;
Jee Sun Min
a
;
Doyun Kim
a
;
Yu Fen Zheng
a
;
Karabasappa Mailar
b
;
Won Jun Choi
b
;
Choongho Lee
b
;
Soo Kyung Bae
a
;
baesk@catholic.ac.kr
;
espero97@hanmail.net
关键词:
AUC0-t
;
total
area under the
plasma
concentration&minus
;
time curve from time zero to time t
;
AUC0-&infin
;
total
area under the
plasma
concentration&minus
;
time curve from time zero to time infinity
;
F
;
bioavailability
;
Cl
;
total
plasma
clearance
;
Cmax
;
peak
plasma
concentration
;
IS
;
internal standard
;
LC&ndash
;
MS/MS
;
liquid chromatography&ndash
;
tandem mass spectrometry
;
LLOQ
;
lower limit of quantitation
;
QC
;
quality control
;
RE
;
relative error
;
RSD
;
relative standard deviation
;
Vd
;
steady-state
刊名:Journal of Pharmaceutical and Biomedical Analysis
出版年:2017
2.
Pharmacokinetics of Ethionamide Delivered in Spray-Dried Microparticles to the Lungs of Guinea Pigs
作者:
Lucila Garcia-Contreras
1
;
lucila-garcia-contreras@ouhsc.edu
;
Danielle J. Padilla-Carlin
2
;
Jean Sung
3
;
4
;
Jarod VerBerkmoes
3
;
Pavan Muttil
5
;
Katharina Elbert
3
;
Charles Peloquin
6
;
David Edwards
3
;
Anthony Hickey
7
关键词:
tuberculosis
;
ethionamide
;
porous particles
;
bioavailability
;
pharmacokinetics and pulmonary absorption
刊名:Journal of Pharmaceutical Sciences
出版年:2017
3.
Could post-weaning dietary chia seed mitigate the development of dyslipidemia, liver steatosis and altered glucose homeostasis in offspring exposed to a sucrose-rich diet from utero to adulthood?
作者:
M.A. Fortino
;
M.E. Oliva
;
S. Rodriguez
;
Y.B. Lombardo
;
A. Chicco
;
achicco@fbcb.unl.edu.ar
关键词:
Chia-seed
;
α-linolenic acid (ALA)
;
Dyslipidemia
;
Liver steatosis
;
Glucose homeostasis
;
Blood pressure
刊名:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
出版年:2017
4.
Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats
作者:
Ola Sternebring
;
Jesper Kammersgaard Christensen
;
Inga Bjø
;
rnsdottir
;
Inbj@novonordisk.com" class="auth_mail" title="E-mail the corresponding author
关键词:
ADME
;
absorption
;
distribution
;
metabolism
;
and excretion
;
AMS
;
accelerator mass spectrometry
;
AUC
;
area under the
plasma
concentration&ndash
;
time curve from zero to infinity
;
AUC[0&ndash
;
t]
;
area under the
plasma
concentration&ndash
;
time curves from zero to time t
;
AUCextrap
;
extrapolated area under the
plasma
concentration&ndash
;
time curves from the last sampling time point to infinity
;
CL
;
total
plasma
clearance
;
CLd
;
intercompartmental distribution
clearance
;
C0
;
concentration at time zero
刊名:European Journal of Pharmaceutical Sciences
出版年:2016
5.
Pharmacokinetics, tissue distribution and excretion of 40 kDa PEG and PEGylated rFVIII (N8-GP) in rats
作者:
Inga Bjø
;
rnsdottir
;
Inbj@novonordisk.com" class="auth_mail" title="E-mail the corresponding author
;
Ola Sternebring
;
Wendela A. Kappers
;
Helle Selvig
;
Hanne T. Kornø
;
Jesper B. Kristensen
;
Morten A. Bagger
关键词:
AUC
;
area under the concentration-time curve
;
CL
;
total
plasma
clearance
;
CLd
;
intercompartmental distribution
clearance
;
C0
;
concentration at time zero
;
CMP-NAN
;
cytidine-5&prime
;
-monophospho-N-acetylneuraminic acid
;
CNS
;
central nervous system
;
EDTA
;
ethylenediaminetetraacetic acid
;
ELISA
;
enzyme-linked immunosorbent assay
;
FIXa
;
coagulation Factor FIXa
;
FVIII
;
coagulation Factor VIII
;
FX
;
coagulation Factor FX
;
GSC
;
glycyl sialic acid cytidine monophosphate
;
HPLC
;
high-performance liquid chro
刊名:European Journal of Pharmaceutical Sciences
出版年:2016
6.
Application of a novel liquid chromatography/tandem mass spectrometry method for the determination of antazoline in human
plasma
: Result of ELEPHANT-I [ELEctrophysiological, pharmacokinetic and hemodynamic effects of PHenazolinum (ANTazoline mesylate)] hu
作者:
Joanna Giebułtowicz
a
;
joanna.giebultowicz@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author
;
Roman Piotrowski
b
;
Jakub Baran
b
;
Piotr Kułakowski
b
;
Piotr Wroczyński
a
关键词:
AF
;
atrial fibrillation
;
AN-PAF
;
Clinical efficacy of ANtazoline in rapid cardioversion of Paroxysmal Atrial Fibrillation
;
a single center
;
randomized
;
double blind
;
placebo-controlled study
;
AUCt
;
area under the
plasma
concentration-time curve from time zero to time t
;
AUC&infin
;
area under the
plasma
concentration-time curve from time zero to infinity
;
C0
;
back-extrapolated
plasma
drug concentration at time zero following bolus intravenous injection
;
Cl
;
apparent
total
body
clearance
of the d
刊名:Journal of Pharmaceutical and Biomedical Analysis
出版年:2016
7.
Plasma
vemurafenib exposure and pre-treatment hepatocyte growth factor level are two factors contributing to the early peripheral lymphocytes depletion in BRAF-mutated melanoma patients
作者:
Alicja Puszkiel
a
;
Mé
;
lanie White-Koning
b
;
Nicolas Dupin
c
;
d
;
Nora Kramkimel
c
;
Audrey Thomas-Schoemann
a
;
e
;
Gaë
;
lle Noé
;
a
;
e
;
Nicolas Chapuis
f
;
Michel Vidal
a
;
e
;
Franç
;
ois Goldwasser
d
;
g
;
Etienne Chatelut
b
;
h
;
Benoit Blanchet
a
;
benoit.blanchet@aphp.fr" class="auth_mail" title="E-mail the corresponding author
关键词:
AAG
;
alpha-1 acid glycoprotein
;
AJCC
;
American Joint Committee on Cancer
;
ALT
;
alanine aminotransferase
;
AST
;
aspartate aminotransferase
;
AUC
;
Area Under the Curve
;
CI
;
Confidence Interval
;
CL/F
;
Apparent
clearance
;
CRP
;
C Reactive Protein
;
EGFR
;
Epidermal Growth Factor Receptor
;
ECOG
;
Eastern Cooperative Oncology Group
;
F
;
Bioavailability
;
FOCE-I
;
First-Order Conditional Estimation with Interaction
;
HGF
;
Hepatocyte Growth Factor
;
HPLC
;
High Performance Liquid Chromatography
;
IOV
;
Inter-occasion
刊名:Pharmacological Research
出版年:2016
8.
Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors
作者:
Yasuhiro Imaeda
a
;
yasuhiro.imaeda@takeda.com" class="auth_mail" title="E-mail the corresponding author
;
Michiko Tawada
a
;
Shinkichi Suzuki
a
;
Masaki Tomimoto
a
;
Mitsuyo Kondo
a
;
Naoki Tarui
a
;
Tsukasa Sanada
a
;
Ray Kanagawa
a
;
Gyorgy Snell
b
;
Craig A. Behnke
b
;
&dagger
;
;
Keiji Kubo
a
;
Takanobu Kuroita
a
关键词:
AcOH
;
acetic acid
;
Ang I
;
angiotensin I
;
Ang II
;
angiotensin II
;
AUC
;
area under the blood concentration&ndash
;
time curve
;
C5min
;
concentration in
plasma
5
;
min after administration
;
CL
total
;
total
clearance
;
Cmax
;
maximum concentration in
plasma
;
DIEA
;
N
;
N-diisopropylethylamine
;
Et3N
;
triethylamine
;
EtOAc
;
ethyl acetate
;
EtOH
;
ethanol
;
F
;
rat bioavailability
;
HAC
;
heavy atom count
;
HOBt
;
1-hydroxybenzotriazole hydrate
;
hPRA
;
human
plasma
renin activity
;
i-PrOH
;
isopropanol
;
LE
;
ligand effic
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
9.
Sustained effects of a protein and lipid preload on glucose tolerance in type 2 diabetes patients
作者:
D. Tricò
;
a
;
domenico.trico@for.unipi.it" class="auth_mail" title="E-mail the corresponding author
;
E. Filice
a
;
S. Baldi
a
;
S. Frascerra
a
;
A. Mari
b
;
A. Natali
a
关键词:
FFM
;
fat-free mass
;
FPG
;
fasting
plasma
glucose
;
FPI
;
fasting
plasma
insulin
;
GIP
;
glucose-dependent insulinotropic polypeptide
;
GLP-1
;
glucagon-like peptide-1
;
iAUC
;
incremental area under the curve
;
ISR
;
insulin secretion rate
;
ISR@FPG
;
insulin secretion rate at fasting
plasma
glucose concentration
;
OGIS
;
oral glucose insulin sensitivity
;
T2D
;
type 2 diabetes
刊名:Diabetes & Metabolism
出版年:2016
10.
Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice
作者:
Sabine M. Poppenborg
a
;
s.poppenborg@medac.de" class="auth_mail" title="E-mail the corresponding author
;
Julia Wittmann
b
;
j.wittmann@celares.com" class="auth_mail" title="E-mail the corresponding author
;
Wolfgang Walther
c
;
Wolfgang.Walther@epo-berlin.com" class="auth_mail" title="E-mail the corresponding author
;
Gunda Brandenburg
a
;
g.brandenburg@medac.de" class="auth_mail" title="E-mail the corresponding author
;
Ralf Krä
;
hmer
b
;
r.kraehmer@celares.com" class="auth_mail" title="E-mail the corresponding author
;
Joachim Baumgart
a
;
j.baumgart@medac.de" class="auth_mail" title="E-mail the corresponding author
;
Frank Leenders
b
;
f.leenders@celares.com" class="auth_mail" title="E-mail the corresponding author
关键词:
ALL
;
acute lymphoblastic leukemia
;
ASNase
;
l-asparaginase
;
AUC
;
area under the curve
;
CL
;
total
plasma
clearance
;
ELISA
;
enzyme-linked immunosorbent assay
;
PD
;
pharmacodynamics
;
PEG-rASNase
;
pegylated recombinant E. colil-Asparaginase
;
PEG
;
polyethylene glycol
;
PK
;
pharmacokinetics
刊名:European Journal of Pharmaceutical Sciences
出版年:2016
1
2
3
4
5
6
7
8
9
按检索点细分(554)
题名(2)
关键词(20)
文摘(524)
按出版年细分(554)
2027年及以后(12)
2017年(3)
2016年(16)
2015年(3)
2013年(15)
2012年(26)
2011年(24)
2010年(21)
2009年(17)
2008年(29)
2007年(18)
2006年(23)
2005年(19)
2004年(29)
2003年(30)
2002年(31)
2001年(37)
2000年(28)
2000年及以前(173)
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via
email
.