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Wiley电子期刊(3)
SpringerLink电子期刊(16)
Elsevier电子期刊(55)
ACS电子期刊(14)
在“
Elsevier电子期刊
”中,
命中:
55
条,耗时:小于0.01 秒
在所有数据库中总计命中:
88
条
1.
Structure-guided development of covalent TAK1 inhibitors
作者:
Li Tan
a
;
b
;
j
;
Deepak Gurbani
c
;
d
;
j
;
Ellen L. Weisberg
e
;
f
;
John C. Hunter
c
;
d
;
Lianbo Li
c
;
d
;
Douglas S. Jones
g
;
h
;
Scott B. Ficarro
a
;
b
;
Samar Mowafy
a
;
b
;
i
;
Chun-Pong Tam
a
;
b
;
Suman Rao
a
;
b
;
g
;
Guangyan Du
a
;
b
;
James D. Griffin
e
;
f
;
Peter K. Sorger
g
;
Jarrod A. Marto
a
;
b
;
Kenneth D. Westover
c
;
d
;
Kenneth.Westover@UTSouthwestern.edu
;
Nathanael S. Gray
a
;
b
;
Nathanael_Gray@dfci.harvard.edu
关键词:
Structure-based design
;
TAK1 kinase inhibitors
;
Covalent inhibitors
;
2
;
4
-
Disubstituted
pyrimidine
;
Structure-activity relationship
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
2.
Au(I)-catalyzed domino intramolecular cyclization for the synthesis of 2,
4
-
disubstituted
pyrimidine
s
作者:
Haiying Zhan
;
Longbin Chen
;
Jingwen Tan
;
Hua Cao
;
caohua@gdput.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
Pyrimidine
s
;
Gold
;
Domino reaction
;
Synthesis
;
Intramolecular cyclization
刊名:Catalysis Communications
出版年:2016
3.
Rational design, synthesis and biological evaluation of 1,3,
4
-oxadiazole
pyrimidine
derivatives as novel pyruvate dehydrogenase complex E1 inhibitors
作者:
Haifeng He
a
;
&dagger
;
;
Wei Wang
b
;
&dagger
;
;
Yuan Zhou
a
;
Qin Xia
a
;
Yanliang Ren
a
;
Jiangtao Feng
a
;
Hao Peng
a
;
Hongwu He
a
;
he1208@mail.ccnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Lingling Feng
a
;
fll708@mail.ccnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
Antibacterial activity
;
PDHc-E1 inhibitor
;
Cyanobacteria
;
1
3 ;
4
-Oxadiazole
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
4.
2-Chloro-
4
-tetrafluorophenoxy
pyrimidine
: a versatile reagent for C-2 prior to C-
4
functionalizations
作者:
Michael O&rsquo
;
Donnell
;
Jean-Damien Charrier
;
jean-damien_charrier@vrtx.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Pyrimidine
;
Tetrafluorophenoxy
;
Suzuki
;
Negishi
;
Sonogashira
;
Regioselective functionalization
刊名:Tetrahedron Letters
出版年:2016
5.
Synthesis of novel ethyl 2,
4
-
disubstituted
8-(trifluoromethyl)pyrido[2′,3′:3,
4
]pyrazolo[1,5-a]
pyrimidine
-9-carboxylate derivatives as promising anticancer agents
作者:
N. Ravi Kumar
a
;
Y. Poornachandra
b
;
D. Krishna Swaroop
a
;
G. Jitender Dev
a
;
C. Ganesh Kumar
b
;
B. Narsaiah
a
;
narsaiah@iict.res.in" class="auth_mail" title="E-mail the corresponding author
关键词:
Pyrazolo[3
;
4
-b]pyridine
;
Pyrimidine
;
α
;
β unsaturated ketones
;
1
;
3 diketones
;
Anticancer activity
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
6.
Discovery of novel 6,7-
disubstituted
-
4
-phenoxyquinoline derivatives bearing 5-(aminomethylene)
pyrimidine
-2,
4
,6-trione moiety as c-Met kinase inhibitors
作者:
Qidong Tang
;
Guogang Zhang
;
Xinming Du
;
Wufu Zhu
;
Ruijuan Li
;
Huafang Lin
;
Pengcheng Li
;
Maosheng Cheng
;
Ping Gong
;
Yanfang Zhao
关键词:
c-Met
;
Receptor tyrosine kinase
;
Anti-tumor
;
Quinoline derivatives
;
Pyrimidine
-2
4 ;
6-trione
刊名:Bioorganic and Medicinal Chemistry
出版年:15 February, 201
4
7.
Facile and regioselective synthesis of novel 2,
4
-
disubstituted
-5-fluoro
pyrimidine
s as potential kinase inhibitors
作者:
Hiroki Wada
a
;
hiroki.wada@astrazeneca.com
;
Lili Cheng
b
;
Ji Jiang
b
;
Zhigan Jiang
b
;
Jun Xie
b
;
Tao Hu
b
;
Hitesh Sanganee
c
;
Tim Luker
d
关键词:
5-Fluoro-2
;
4
-
disubstituted
pyrimidine
;
5-FU analogues
;
MeO protecting group
;
Regioselective synthesis
;
Pd coupling reaction
;
Kinase inhibitor
刊名:Tetrahedron Letters
出版年:2012
8.
Mechanistic aspect of ring transformations in the reaction of 5-nitro-
4
-pyrimidinone with acetophenone derivatives and cycloalkanones depending on the electron density/ring size of the ketone
作者:
Nagatoshi Nishiwaki
;
nishiwaki.nagatoshi@kochi-tech.ac.jp
;
Ryuichi Sugimoto
;
Kazuhiko Saigo
;
Kazuya Kobiro
关键词:
Bicyclic compound
;
Cycloalkanone
;
Nitropyridone
;
Pyrimidine
;
Ring transformation
刊名:Tetrahedron Letters
出版年:2013
9.
Design, synthesis and evaluation of 2,
4
-
disubstituted
pyrimidine
s as cholinesterase inhibitors
作者:
Tarek Mohamed
;
Praveen P.N. Rao
关键词:
Acetylcholinesterase AChE
;
Butyrylcholinesterase BuChE
;
2
;
4
-
Disubstituted
pyrimidine
s
;
Molecular modeling
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2010
10.
Pyridofuran substituted
pyrimidine
derivatives as HCV replication (replicase) inhibitors
作者:
Frank Bennett
;
Hollis S. Kezar III
;
Vinay Girijavallabhan
;
Yuhua Huang
;
Regina Huelgas
;
R
;
all Rossman
;
Neng-Yang Shih
;
John J. Piwinski
;
Malcolm MacCoss
;
Cecil D. Kwong
;
Jeremy L. Clark
;
Anita T. Fowler
;
Feng Geng
;
Abhijit Roychowdhury
;
Robert C. Reynolds
;
Joseph A. Maddry
;
Subramaniam Ananthan
;
John A. Secrist III
;
Cheng Li
;
Robert Chase
;
et al.
关键词:
HCV replication inhibitor
;
HCV replicase inhibitor
;
Carbanucleoside-like
;
5-Aryl
pyrimidine
;
5-Pyridofuranyl
pyrimidine
;
Hepatitis
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2012
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