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SpringerLink电子期刊(56)
Elsevier电子期刊(49)
在“
Elsevier电子期刊
”中,
命中:
49
条,耗时:小于0.01 秒
在所有数据库中总计命中:
105
条
1.
Synthesis and biological evaluation of hesperetin derivatives as agents inducing apoptosis
作者:
Kang-Yeoun Jung
a
;
d
;
Jihyun Park
b
;
d
;
Young-Sung Han
a
;
Young Han Lee
c
;
Soon Young Shin
c
;
shinsy@konkuk.ac.kr
;
Yoongho Lim
b
;
yoongho@konkuk.ac.kr
关键词:
GI50
;
half-maximal cell growth inhibitory concentration
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
2.
Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines
作者:
Kerri L. Shelton
a
;
Michael A. DeBord
a
;
Patrick O. Wagers
;
Marie R. Southerland
;
Travis M. Williams
;
Nikki K. Robishaw
;
Leah P. Shriver
;
Claire A. Tessier
;
Matthew J. Panzner
;
Wiley J. Youngs
;
youngs@uakron.edu
关键词:
NCI
;
National Cancer Institute
;
IC50
;
inhibitory concentration 50%
;
NSCLC
;
non-small cell lung cancer
;
MTT
;
3-(4
;
5-dimethylthiazol-2-yl)-2
;
5-diphenyltetrazolium bromide
;
SAR
;
structure-activity relationship
;
GI50
;
growth inhibition 50%
;
TGI
;
total growth inhibition
;
LC50
;
lethal concentration 50%
;
DTP
;
Developmental Therapeutics Program
;
2-HPβCD
;
2-hydropropyl-β-cyclodextrin
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
3.
Piperlongumine derived cyclic sulfonamides (sultams): Synthesis and in vitro exploration for therapeutic potential against HeLa cancer cell lines
作者:
Nitin P. Lad
a
;
b
;
Sarang Kulkarni
b
;
Rajiv Sharma
b
;
Malcolm Mascarenhas
b
;
Mahesh R. Kulkarni
a
;
b
;
Shivaji S. Pandit
a
;
akankshapandit2002@yahoo.com
关键词:
Piperlongumine (PL) derived cyclic sulfonamide (sultams)
;
Ring closing metathesis
;
Anticancer
;
GI50
values
刊名:European Journal of Medicinal Chemistry
出版年:2017
4.
3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells
作者:
Chatchakorn Eurtivong
a
;
Victor Semenov
b
;
Marina Semenova
c
;
d
;
Leonid Konyushkin
b
;
Olga Atamanenko
b
;
Jó
;
hannes Reynisson
a
;
j.reynisson@auckland.ac.nz
;
Alex Kiselyov
e
关键词:
Microtubule-destabilisation
;
Sea urchin embryo assay
;
Anticancer
;
Thieno[2
;
3-b]pyridines
;
Molecular modelling
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
5.
In silico selection and cell-based characterization of selective and bioactive compounds for androgen-dependent prostate cancer cell
作者:
Elisa C. Santa Cruz
;
Adriel R. Carecho
;
Marta E. Saidel
;
Carlos Alberto Montanari
;
Andrei Leitã
;
o
;
andleitao@iqsc.usp.br
关键词:
ADT
;
androgen deprivation therapy
;
AR
;
androgen receptor
;
LBD
;
ligand binding domain
;
PCa
;
prostate cancer
;
SARM
;
selective androgen receptor modulator
;
VS
;
virtual screening
;
SBVS
;
structure-based virtual screening
;
WCRF
;
World Cancer Research Fund International
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
6.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents
作者:
Roheeth Kumar Pavana
a
;
Shruti Choudhary
a
;
Anja Bastian
b
;
Michael A. Ihnat
c
;
Ruoli Bai
d
;
Ernest Hamel
d
;
Aleem Gangjee
a
;
gangjee@duq.edu
关键词:
AA
;
antiangiogenic agents
;
MTA
;
microtubule targeting agents
;
VEGFR-2
;
vascular endothelial growth factor receptor-2
;
PDGFR-β
;
platelet-derived growth factor receptor-β
;
CAM
;
chorioallantoic membrane
;
CA
;
combretastatin A-4
;
Pgp
;
P-glycoprotein
;
EGFR
;
epidermal growth factor receptor
;
TBS
;
Tris-buffered saline
;
HRP
;
horseradish peroxidase
;
PY
;
phosphotyrosine
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
7.
Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors
作者:
Ju-Hyeon Lee
a
;
c
;
1
;
Sang Chul Shin
b
;
d
;
1
;
Seon Hee Seo
a
;
Young Ho Seo
e
;
Nakcheol Jeong
c
;
Chan-Wha Kim
d
;
Eunice EunKyeong Kim
b
;
eunice@kist.re.kr
;
Gyochang Keum
a
;
gkeum@kist.re.kr
关键词:
Hsp90
;
Structure-based design
;
Cancer
;
Antiproliferative
;
Pyrrolo[2
;
3-d]pyrimidines
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
8.
Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents
作者:
Davide Carta
a
;
Roberta Bortolozzi
b
;
Mattia Sturlese
a
;
Veronica Salmaso
a
;
Ernest Hamel
c
;
Giuseppe Basso
b
;
Laura Calderan
a
;
Luigi Quintieri
a
;
Stefano Moro
a
;
Giampietro Viola
b
;
Maria Grazia Ferlin
a
;
mariagrazia.ferlin@unipd.it
关键词:
Microtubules
;
Phenylpyrroloquinolinone
;
Tubulin
;
Apoptosis
;
Molecular docking
;
Structure-activity relationships
刊名:European Journal of Medicinal Chemistry
出版年:2017
9.
Novel benzothiazine-piperazine derivatives by peptide-coupling as potential anti-proliferative agents
作者:
Ramineni Venkatesh
a
;
Suresh Kasaboina
a
;
Deepthi Bidayat
a
;
U Nikhil Kumar
a
;
Nishant Jain
b
;
Saritha Jostna Tangeda
d
;
Rajashaker Bantu
a
;
Sridhara Janardhan
c
;
;
Lingaiah Nagarapu
a
;
lnagarapuiict@yahoo.com
;
nagarapu@iict.res.in
关键词:
Peptide-coupling
;
Anti-proliferative activity
;
Molecular docking
;
Benzothiazine-piperazine
;
HDAC8
;
EHMT2
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
10.
Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity
作者:
Carole-Anne Lefebvre
a
;
1
;
Elsa Forcellini
a
;
1
;
Sophie Boutin
a
;
Marie-France Cô
;
té
;
b
;
René
;
C.-Gaudreault
b
;
c
;
Patrick Mathieu
d
;
Patrick Lagü
;
e
e
;
Jean-Franç
;
ois Paquin
a
;
jean-francois.paquin@chm.ulaval.ca
关键词:
Pyrimidine
;
Sulfamide
;
Anticancer activities
;
Structure-activity relationships (SARs)
;
Growth inhibition
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
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