设为首页
收藏本站
网站地图
|
English
|
公务邮箱
About the library
Background
History
Leadership
Organization
Readers' Guide
Opening Hours
Collections
Help Via Email
Publications
Electronic Information Resources
常用资源
电子图书
期刊论文
学位会议
外文资源
特色专题
内部出版物
SpringerLink电子期刊(5)
NATURE电子期刊(2)
Elsevier电子期刊(16)
ACS电子期刊(12)
在“
Elsevier电子期刊
”中,
命中:
16
条,耗时:小于0.01 秒
在所有数据库中总计命中:
35
条
1.
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (
NAMPT
)
inhibitors
with potential for the treatment of cancer and axonopathies
作者:
David E. Clark
a
;
david.clark@crl.com" class="auth_mail" title="E-mail the corresponding author
;
Bohdan Waszkowycz
a
;
&dagger
;
;
Melanie Wong
a
;
Peter M. Lockey
a
;
Robert Adalbert
c
;
&Dagger
;
;
Jonathan Gilley
c
;
&Dagger
;
;
Jonathan Clark
b
;
Michael P. Coleman
c
;
&Dagger
;
关键词:
NAMPT
;
Virtual screening
;
Axon degeneration
;
Molecular docking
;
Similarity searching
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
2.
Identification of benzothiophene amides as potent
inhibitors
of human nicotinamide phosphoribosyltransferase
作者:
Wei Chen
&dagger
;
;
Guoqiang Dong
&dagger
;
;
Shipeng He
&dagger
;
;
Tianying Xu
;
Xia Wang
;
Na Liu
;
Wannian Zhang
;
Chaoyu Miao
;
cymiao@smmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Chunquan Sheng
;
shengcq@hotmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Nampt
inhibitors
;
Antiproliferative activity
;
Structure&ndash
;
activity relationship
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
3.
Improved synthesis of MC4-PPEA and the biological evaluation of its hydroxymethyl derivative
作者:
Keivan Sadrerafi
;
Emilia O. Zargham
;
Mark W. Lee Jr.
;
leemw@missouri.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Nampt
;
nicotinamide phosphoribosyltransferase
;
MC4-PPEA
;
1-(4&prime
;
-(trans-3&Prime
;
-(3‴-pyridyl) acrylamide)butyl)-1
;
7-dicarba-closo-dodecaborane
;
BNCT
;
boron neutron capture therapy
;
BOP
;
benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate
;
HMPA
;
hexamethylphosphoramide
;
PAC
;
trans-3-(3&prime
;
-pyridyl)acryloyl chloride
;
IC50
;
half maximal inhibitory concentrations
;
MTT assay
;
microculture tetrazolium assay
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
4.
Reciprocal regulation by hypoxia-inducible factor-2α and the
NAMPT
-NAD
+
-SIRT axis in articular chondrocytes is involved in osteoarthritis
作者:
H. Oh
&dagger
;
;
a
;
J.-S. Kwak
&dagger
;
;
a
;
S. Yang
&dagger
;
;
M.-K. Gong
&dagger
;
;
J.-H. Kim
&dagger
;
;
&Dagger
;
;
J. Rhee
&dagger
;
;
S.K. Kim
&dagger
;
;
H.-E. Kim
&dagger
;
;
J.-H. Ryu
&dagger
;
;
§
;
;
J.-S. Chun
&dagger
;
;
jschun@gist.ac.kr" class="auth_mail" title="E-mail the corresponding author
关键词:
Hypoxia-inducible factor (HIF)
;
NAD+ biosynthesis
;
Sirtuin
;
Chondrocytes
;
Osteoarthritis
刊名:Osteoarthritis and Cartilage
出版年:2015
5.
Fragment-based design of 3-aminopyridine-derived amides as potent
inhibitors
of human nicotinamide phosphoribosyltransferase (
NAMPT
)
作者:
Peter S. Dragovich
;
Guiling Zhao
;
Timm Baumeister
;
Br
;
on Bravo
;
Anthony M. Giannetti
;
Yen-Ching Ho
;
Rongbao Hua
;
Guangkun Li
;
Xiaorong Liang
;
Xiaolei Ma
;
Thomas O鈥橞rien
;
Angela Oh
;
Nicholas J. Skelton
;
Chengcheng Wang
;
Weiru Wang
;
Yunli Wang
;
Yang Xiao
;
Po-wai Yuen
;
Mark Zak
;
Qiang Zhao
;
Xiaozhang Zheng
;
et al.
关键词:
Nicotinamide phosphoribosyltransferase
;
NAMPT
;
Fragment-based design
;
Structure-based design
;
X-ray crystal structure
;
Surface plasmon resonance
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:1 February, 2014
6.
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (
Nampt
)
inhibitors
作者:
Xiaozhang Zheng
;
Timm Baumeister
;
Alex
;
re J. Buckmelter
;
Maureen Caligiuri
;
Karl H. Clodfelter
;
Bingsong Han
;
Yen-Ching Ho
;
Nikolai Kley
;
Jian Lin
;
Dominic J. Reynolds
;
Geeta Sharma
;
Chase C. Smith
;
Zhongguo Wang
;
Peter S. Dragovich
;
Angela Oh
;
Weiru Wang
;
Mark Zak
;
Yunli Wang
;
Po-wai Yuen
;
Kenneth W. Bair
关键词:
Nicotinamide phosphoribosyltransferase
;
Nampt
;
cyanoguanidine
;
X-ray crystal structure
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:1 January, 2014
7.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (
NAMPT
)
inhibitors
with reduced CYP2C9 inhibition properties
作者:
Janet Gunzner-Toste
a
;
Guiling Zhao
a
;
Paul Bauer
b
;
Timm Baumeister
b
;
Alexandre J. Buckmelter
b
;
Maureen Caligiuri
b
;
Karl H. Clodfelter
b
;
Bang Fu
c
;
Bingsong Han
b
;
Yen-Ching Ho
b
;
Nikolai Kley
b
;
Xiaorong Liang
a
;
Bianca M. Liederer
a
;
Jian Lin
b
;
Sophie Mukadam
a
;
Thomas O&rsquo
;
Brien
a
;
Angela Oh
a
;
Dominic J. Reynolds
b
;
Geeta Sharma
b
;
Nicholas Skelton
a
;
Chase C. Smith
b
;
Jasleen Sodhi
a
;
Weiru Wang
a
;
Zhongguo Wang
b
;
Yang Xiao
a
;
Po-wai Yuen
c
;
Mark Zak
a
;
Lei Zhang
c
;
Xiaozhang Zheng
b
;
Kenneth W. Bair
b
;
Peter S. Dragovich
a
;
dragovich.peter@gene.com
关键词:
Nicotinamide phosphoribosyltransferase
;
NAMPT
;
X-ray crystal structure
;
Cytochrome P450
;
CYP2C9
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2013
8.
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent
inhibitors
of human nicotinamide phosphoribosyltransferase (
NAMPT
)
作者:
Peter S. Dragovich
;
Kenneth W. Bair
;
Timm Baumeister
;
Yen-Ching Ho
;
Bianca M. Liederer
;
Xiongcai Liu
;
Yongbo Liu
;
Thomas O¡¯Brien
;
Jason Oeh
;
Deepak Sampath
;
Nicholas Skelton
;
Leslie Wang
;
Weiru Wang
;
Hongxing Wu
;
Yang Xiao
;
Po-wai Yuen
;
Mark Zak
;
Lei Zhang
;
Xiaozhang Zheng
关键词:
Nicotinamide phosphoribosyltransferase
;
NAMPT
;
Aqueous solubility
;
X-ray crystal structure
;
Tumor metabolism
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2013
9.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent
inhibitors
of human nicotinamide phosphoribosyltransferase (
NAMPT
)
作者:
Xiaozhang Zheng
;
Kenneth W. Bair
;
Paul Bauer
;
Timm Baumeister
;
Krista K. Bowman
;
Alex
;
re J. Buckmelter
;
Maureen Caligiuri
;
Karl H. Clodfelter
;
Yezhen Feng
;
Bingsong Han
;
Yen-Ching Ho
;
Nikolai Kley
;
Hong Li
;
Xiaorong Liang
;
Bianca M. Liederer
;
Jian Lin
;
Justin Ly
;
Thomas O¡¯Brien
;
Jason Oeh
;
Angela Oh
;
et al.
关键词:
Nicotinamide phosphoribosyltransferase (
NAMPT
)
;
X-ray crystal structure
;
Tumor metabolism
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2013
10.
Visfatin contributes to the differentiation of monocytes into macrophages through the differential regulation of inflammatory cytokines in THP-1 cells
作者:
Mi Ran Yun
;
Jeong Mi Seo
;
Hyun Young Park
关键词:
DeM
;
differentiated macrophages
;
DiM
;
differentiating macrophages
;
ERK
;
extracellular signal-regulated kinase
;
FACS
;
fluorescence-activated cell sorter
;
FBS
;
fetal bovine serum
;
HRP
;
horseradish peroxidase
;
iNOS
;
inducible nitric oxide synthase
;
IL-1Ra
;
IL-1 receptor antagonist
;
IL
;
interleukin (IL)
;
I魏B-伪
;
inhibitors
of NF-魏B-伪
;
MMP9
;
matrix metalloproteinases-9
;
MO
;
monocytes
;
NAMPT
;
nicotinamide phosphoribosyltransferase
;
NF-魏B
;
nuclear factor-魏B
;
OD
;
optical density
;
PMA
;
phorbol-12-my
刊名:Cellular Signalling
出版年:April, 2014
1
2
按检索点细分(16)
题名(8)
关键词(2)
文摘(13)
按出版年细分(16)
2027年及以后(2)
2016年(3)
2015年(1)
2013年(3)
2012年(1)
2011年(1)
2010年(3)
2000年及以前(2)
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via
email
.