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Elsevier电子期刊(4149)
在“
Elsevier电子期刊
”中,
命中:
4,149
条,耗时:0.0429745 秒
在所有数据库中总计命中:
5,406
条
1.
Synthesis of novel steroidal
agonist
s,
partial
agonist
s, and ant
agonist
s for the glucocorticoid receptor
作者:
Zhuang Jin
a
;
Hua Lin
a
;
Sathish Srinivasan
b
;
Jerome C. Nwachukwu
b
;
Nelson Bruno
b
;
Patrick R. Griffin
a
;
Kendall W. Nettles
b
;
;
Theodore M. Kamenecka
a
;
kameneck@scripps.edu
关键词:
AF-1
;
activation function-1
;
AF-2
;
activation function-2
;
AP-1
;
activator protein 1
;
dppp
;
1
;
3-bis(diphenylphosphino)propane
;
DEX
;
dexamethasone
;
DIEA
;
N
;
N-diisopropylethylamine
;
FKBP5
;
FK506-binding protein 5
;
GR
;
glucocorticoid receptor
;
GRE
;
glucocorticoid-response element
;
HATU
;
1-[bis(dimethylamino)methylene]-1H-1
2 ;
3-triazolo[4
;
5-b]pyridinium 3-oxid hexafluorophosphate
;
IL-6
;
Interleukin-6
;
LBD
;
ligand-binding domain
;
LPS
;
lipopolysaccharide
;
MMTV
;
mouse mammary tumor virus
;
NF-κB
;
nuclear
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
2.
Development of spiroguanidine-derived α7 neuronal nicotinic receptor
partial
agonist
s
作者:
Matthew D. Hill
;
matthew.hill@bms.com
;
Haiquan Fang
;
Sivarao V. Digavalli
;
Francine L. Healy
;
Lizbeth Gallagher
;
Debra Post-Munson
;
Ping Chen
;
Joanne Natale
;
Yulia Benitex
;
Daniel Morgan
;
Nicholas Lodge
;
Linda Bristow
;
John E. Macor
;
Richard E. Olson
关键词:
α7 nicotinic acetylcholine receptor
;
Schizophrenia
;
5-HT3A receptor
;
Spiroguanidine
;
Immediate early genes
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
3.
Estimation of the receptor-state affinity constants of ligands in functional studies using wild type and constitutively active mutant receptors: Implications for estimation of
agonist
bias
作者:
Frederick J. Ehlert
a
;
b
;
fjehlert@uci.edu
;
Richard S.L. Stein
b
关键词:
Receptor state affinity constants
;
Constitutive activity
;
Agonist
bias
;
System bias
;
Monod-Wyman-Changeux model
;
Observed affinity
;
Efficacy
;
Receptor activation
;
Active state
;
Inactive state
刊名:Journal of Pharmacological and Toxicological Methods
出版年:2017
4.
From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective
partial
agonism at α4β2 nicotinic acetylcholine receptor
作者:
Cristiano Bolchi
a
;
Francesco Bavo
a
;
Cecilia Gotti
b
;
Laura Fumagalli
a
;
Francesca Fasoli
b
;
Matteo Binda
a
;
Vanessa Mucchietto
b
;
Miriam Sciaccaluga
c
;
Simona Plutino
d
;
Sergio Fucile
c
;
d
;
Marco Pallavicini
a
;
marco.pallavicini@unimi.it
关键词:
α4β2 nAChR
;
α3β4 nAChR
;
Benzodioxane
;
Pyridodioxane
;
Partial
agonism
;
Antagonism
刊名:European Journal of Medicinal Chemistry
出版年:2017
5.
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT
1A
receptor
agonist
s
作者:
Silvia Franchini
a
;
Leda Ivanova Manasieva
a
;
Claudia Sorbi
a
;
Umberto M. Battisti
a
;
Paola Fossa
b
;
Elena Cichero
b
;
Nunzio Denora
c
;
Rosa Maria Iacobazzi
c
;
d
;
Antonio Cilia
e
;
Lorenza Pirona
e
;
Simone Ronsisvalle
f
;
Giuseppina Aricò
;
f
;
Livio Brasili
a
;
livio.brasili@unimore.it
关键词:
5-HT1A receptor
;
Agonist
;
Neuroprotection
;
BBB penetration
;
Analgesic activity
刊名:European Journal of Medicinal Chemistry
出版年:2017
6.
Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu
5
negative allosteric modulation
作者:
Xavier Gó
;
mez-Santacana
a
;
b
;
c
;
1
;
James A.R. Dalton
b
;
d
;
Xavier Rovira
e
;
f
;
Jean Philippe Pin
e
;
f
;
Cyril Goudet
e
;
f
;
Pau Gorostiza
c
;
g
;
h
;
Jesú
;
s Giraldo
b
;
d
;
Amadeu Llebaria
a
;
amadeu.llebaria@iqac.csic.es
关键词:
mGlu5
;
Isomers
;
Partial
efficacy
;
NAM
;
Ant
agonist
;
Inverse
agonist
刊名:European Journal of Medicinal Chemistry
出版年:2017
7.
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual
agonist
s endowed with anti-proliferative effects and mitochondrial activity
作者:
Luca Piemontese
a
;
b
;
Carmen Cerchia
c
;
Antonio Laghezza
a
;
Pamela Ziccardi
d
;
Sabina Sblano
a
;
Paolo Tortorella
a
;
Vito Iacobazzi
e
;
f
;
Vittoria Infantino
e
;
g
;
Paolo Convertini
e
;
g
;
Fabrizio Dal Piaz
h
;
Angelo Lupo
d
;
Vittorio Colantuoni
d
;
Antonio Lavecchia
c
;
antonio.lavecchia@unina.it
;
Fulvio Loiodice
a
;
fulvio.loiodice@uniba.it
关键词:
PPAR
;
Docking experiments
;
Mitochondrial biogenesis
;
Anti-proliferative effects
;
Gene expression analysis
刊名:European Journal of Medicinal Chemistry
出版年:2017
8.
Importance of 5/6-aryl substitution on the pharmacological profile of 4ʹ-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1ʹ-biphenyl]-2-carboxylic acid derived PPARγ
agonist
s
作者:
Victoria Obermoser
a
;
1
;
Robert Mauersberger
a
;
1
;
Daniela Schuster
a
;
Monika Czifersky
a
;
Marina Lipova
a
;
Monika Siegl
a
;
Ulrich Kintscher
b
;
Ronald Gust
a
;
Ronald.Gust@uibk.ac.at
关键词:
Peroxisome proliferator-activated receptor γ
;
Pharmacological profile
;
Coactivator recruitment
;
Transactivation assay
;
Molecular modeling
刊名:European Journal of Medicinal Chemistry
出版年:2017
9.
Partial
kappa opioid receptor
agonist
effects in vivo in mice: Biased versus unbiased
作者:
Catherine Guariglia
;
Amelia Dunn
;
Kyle Windisch
;
Eduardo Butelman
;
Brian Reed
;
Mary Jeanne Kreek
刊名:Drug and Alcohol Dependence
出版年:2017
10.
Effect of a dopamine D3 receptor
partial
agonist
on cocaine-induced locomotion and self-administration
作者:
John Paul Bonadonna
1
;
;
Gregory Powell
1
;
Andrew K. Carlson
1
;
Rachel Mendoza
1
;
Robert H. Mach
2
;
Robert R. Luedtke
3
;
Janet L. Neisewander
1
刊名:Drug and Alcohol Dependence
出版年:2017
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