搜索页_Phenyl+chloroethylurea

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Elsevier电子期刊(13)

在“Elsevier电子期刊”中，命中：13条，耗时：小于0.01 秒

在所有数据库中总计命中：13条

1.Intramolecular cyclization of N-phenyl N′(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40

作者：Anna Trzeciakiewicz^a ; ^b ; ^{trzeciakiewicz@gmail.com} ; Sé ; bastien Fortin^a ; ^b ; ^c ; ^{sebastien.fortin.1@ulaval.ca} ; Emmanuel Moreau^a ; ^b ; ^{Emmanuel.Moreau@u-clermont1.fr} ; René ; C.-Gaudreault^c ; ^{rene.c-gaudreault@crsfa.ulaval.ca} ; Jacques Lacroix^c ; ^{Jacques.Lacroix@crsfa.ulaval.ca} ; Christophe Chambon^d ; ^{Christophe.chambon@clermont.inra.fr} ; Yves Communal^e ; ^{Yves.COMMUNAL@cjp.fr} ; Jean-Michel Chezal^a ; ^b ; ^{j-michel.chezal@u-clermont1.fr} ; Elisabeth Miot-Noirault^a ; ^b ; ^{elisabeth.noirault@inserm.fr} ; Bernadette Bouchon^a ; ^b ; ^{bernadette.bouchon@inserm.fr} ; Franç ; oise Degoul^a ; ^b ; ^{francoise.degoul@inserm.fr}

关键词：N-Phenyl-N′ ; -(2-chloroethyl)ureas ; N-Phenyl-4 ; 5-dihydrooxazol-2-amines ; β ; -Tubulin ; Prohibitin ; Alkylation ; Cyclization

刊名：Biochemical Pharmacology

出版年：2011

2.Synthesis, antiproliferative activity evaluation and structure–activity relationships of novel aromatic urea and amide analogues of N-phenyl-N′-(2-chloroethyl)ureas

作者：Sé ; bastien Fortin ; Emmanuel Moreau ; Jacques Lacroix ; Marie-France Cô ; té ; É ; ric Petitclerc ; René ; C.-Gaudreault

关键词：Aromatic ureas ; Aromatic amides ; N-phenyl-N′ ; -(2-chloroethyl)ureas ; CEU ; Anticancer drugs ; Antimitotic agents

刊名：European Journal of Medicinal Chemistry

出版年：2010

3.N-Phenyl-N′-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N′-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?

作者：Sé ; bastien Fortin ; Emmanuel Moreau ; Jacques Lacroix ; Jean-Claude Teulade ; Alex ; re Patenaude ; René ; C-Gaudreault

关键词：Phenyl chloroethylureas ; Combretastatin analogues ; Antimicrotubule agents ; Anti-β ; -tubulin agents ; Antimitotic agents ; Soft alkylating agents ; Anticancer drugs ; Colchicine-binding site ligands

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2007

4.A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N′-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents

作者：Sé ; bastien Fortin ; Philippe Labrie ; Emmanuel Moreau ; Lianhu Wei ; Lakshmi P. Kotra ; René ; C.-Gaudreault

关键词：CoMFA ; CoMSIA ; Phenyl chloroethylurea ; Antimicrotubule agents ; Colchicine-binding site ; Tubulin

刊名：Bioorganic and Medicinal Chemistry

出版年：2008

5.N-Phenyl-N′-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: Role of carbonyl groups in the covalent binding to the colchicine-binding site

作者：Emmanuel Moreau ; Sé ; bastien Fortin ; Jacques Lacroix ; Alex ; re Patenaude ; Jean L.C. Rousseau ; René ; C-Gaudreault

关键词：Phenyl chloroethylureas ; Antimicrotubule agents ; Antitubulin agents ; Antimitotics ; Soft alkylating agents ; Anticancer drugs ; Colchicine-binding site ligands

刊名：Bioorganic and Medicinal Chemistry

出版年：2008

6.N-Phenyl-N′-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: Role of ω-hydroxyl group in the covalent binding to β-tubulin

作者：Sé ; bastien Fortin ; Emmanuel Moreau ; Alex ; re Patenaude ; Michel Desjardins ; Jacques Lacroix ; Jean L.C. Rousseau ; René ; C-Gaudreault

关键词：Phenyl chloroethylurea ; Antimicrotubule agents ; Antitubulin agents ; Antimitotic agents ; Soft alkylating agents ; Anticancer drugs ; Colchicine-binding site ligands

刊名：Bioorganic and Medicinal Chemistry

出版年：2007

7.Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G₀/G₁ phase and thioredoxin-1 nuclear translocation

作者：Jessica S. Fortin ; Marie-France Cô ; té ; Jacques Lacroix ; Alex ; re Patenaude ; É ; ric Petitclerc ; René ; C.-Gaudreault

关键词：Phenyl chloroethylurea ; Thioredoxin-1 ; Alkylating agents ; Anticancer drugs

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2008

8.Selective alkylation of β_II-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents

作者：Jessica S. Fortin ; Marie-France Cô ; té ; Jacques Lacroix ; Michel Desjardins ; É ; ric Petitclerc ; René ; C.-Gaudreault

关键词：Aryl chloroethylurea ; β ; _II-tubulin ; Thioredoxin-1 ; Alkylation ; Selectivity ; Chemo sensitizers ; Radio sensitizers ; Cancer

刊名：Bioorganic and Medicinal Chemistry

出版年：2008

9.Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site

作者：Jessica S. Fortin ; Jacques Lacroix ; Michel Desjardins ; Alex ; re Patenaude ; É ; ric Petitclerc ; René ; C.-Gaudreault

关键词：Phenyl chloroethylurea ; N-Aryl 2-amino-oxazoline ; Antitubulin agents ; Alkylating agents ; Anticancer drugs ; Colchicine-binding site ligands

刊名：Bioorganic and Medicinal Chemistry

出版年：2007

10.Body mass index and prostate-specific antigen failure following brachytherapy for localized prostate cancer: Efstathiou JA, Skowronski RY, Coen JJ, Grocela JA, Hirsch AE, Zietman AL, Mark A. Ritter, D

作者：Mark A. Ritter

关键词：Phenyl chloroethylurea ; Thioredoxin-1 ; Alkylating agents ; Anticancer drugs

刊名：Urologic Oncology: Seminars and Original Investigations

出版年：2008

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