设为首页
收藏本站
网站地图
|
English
|
公务邮箱
About the library
Background
History
Leadership
Organization
Readers' Guide
Opening Hours
Collections
Help Via Email
Publications
Electronic Information Resources
常用资源
电子图书
期刊论文
学位会议
外文资源
特色专题
内部出版物
Wiley电子期刊(6)
NATURE电子期刊(8)
ACS电子期刊(86)
SpringerLink电子期刊(31)
Elsevier电子期刊(117)
在“
Elsevier电子期刊
”中,
命中:
117
条,耗时:0.0319546 秒
在所有数据库中总计命中:
248
条
1.
Ligand
and Target
Discovery
by
Fragment
-
Based
Screening in Human Cells
作者:
Christopher G. Parker
1
;
5
;
cparker@scripps.edu
;
Andrea Galmozzi
1
;
5
;
Yujia Wang
1
;
Bruno E. Correia
2
;
Kenji Sasaki
1
;
Christopher M. Joslyn
1
;
Arthur S. Kim
1
;
Cullen L. Cavallaro
3
;
R. Michael Lawrence
3
;
Stephen R. Johnson
3
;
Iñ
;
igo Narvaiza
4
;
Enrique Saez
1
;
esaez@scripps.edu
;
Benjamin F. Cravatt
1
;
6
;
cravatt@scripps.edu
关键词:
fragment
-
based
ligand
discovery
;
FBLD
;
chemical proteomics
;
mass spectrometry
;
photoreactivity
;
phenotypic screening
;
ligand
s
;
chemical probes
;
PGRMC2
;
adipogenesis
刊名:Cell
出版年:2017
2.
Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications
作者:
Zsuzsa Szondy
a
;
b
;
szondy@med.unideb.hu
;
Anna Pallai
a
;
b
关键词:
mTNF-α
;
TGF-β
;
TNF targeting molecules
;
Effectiveness
刊名:Pharmacological Research
出版年:2017
3.
NMR in drug
discovery
: A practical guide to identification and validation of
ligand
s interacting with biological macromolecules
作者:
Alvar D. Gossert
;
alvar.gossert@novartis.com
;
Wolfgang Jahnke
关键词:
Drug
discovery
;
Validation
;
Fragment
-
based
screening
;
Protein-
ligand
Interactions
刊名:Progress in Nuclear Magnetic Resonance Spectroscopy
出版年:2016
4.
Rule of five in 2015 and beyond: Target and
ligand
structural limitations,
ligand
chemistry structure and drug
discovery
project decisions
作者:
Christopher A. Lipinski
关键词:
Biologically active chemistry space
;
Binding pockets in folded proteins
;
Protein binding pocket evolution
;
Characteristics of protein
ligand
s
;
Natural product chemistry synthons
;
Shape change in natural products
;
H-bonding in natural products
;
Navitoclax a rule of 5 outlier
刊名:Advanced Drug Delivery Reviews
出版年:2016
5.
Fragment
-
based
discovery
of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2
作者:
Tony Christopeit
;
Hanna-Kirsti S. Leiros
;
hanna-kirsti.leiros@uit.no" class="auth_mail" title="E-mail the corresponding author
关键词:
FBDD
;
fragment
based
drug
discovery
;
MBL
;
metallo-β-lactamase
;
PAINS
;
Pan Assay Interference Compounds
;
SBL
;
serine-β-lactamases
;
NDM
;
New Delhi metallo-β-lactamase
;
VIM
;
Verona integron-encoded metallo-β-lactamase
;
IMP
;
Imipenemase
;
SPR
;
surface plasmon resonance
;
ka
;
on-rate
;
kd
;
off-rate
;
KD
;
dissociation constant
;
QM
;
quantum mechanics
;
QPLD
;
QM-polarized
ligand
docking
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
6.
Multi-fields model for predicting target-
ligand
interaction
作者:
Caihua Wang
a
;
Author Vitae
;
Juan Liu
a
;
liujuan@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Author Vitae
;
Fei Luo
a
;
Author Vitae
;
Qian-Nan Hu
b
;
hu_qn@tib.cas.cn" class="auth_mail" title="E-mail the corresponding author
;
Author Vitae
关键词:
Protein representation
;
Ligand
representation
;
Field interaction
;
Target&ndash
;
ligand
interaction
;
Target&ndash
;
ligand
network analysis
刊名:Neurocomputing
出版年:2016
7.
Identification of B. anthracis N
5
-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via
fragment
library screening
作者:
Hao Lei
a
;
Christopher Jones
a
;
Tian Zhu
a
;
Kavankumar Patel
a
;
Nina M. Wolf
b
;
Leslie W.-M. Fung
b
;
Hyun Lee
a
;
danielhl@uic.edu" class="auth_mail" title="E-mail the corresponding author
;
Michael E. Johnson
a
;
mjohnson@uic.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
PurE
;
N5-carboxyaminoimidazole ribonucleotide mutase
;
FBDD
;
fragment
-
based
drug design
;
NMR
;
nuclear magnetic resonance
;
STD-NMR
;
saturation transfer difference nuclear magnetic resonance (NMR)
;
WaterLOGSY NMR
;
water
ligand
observed via gradient spectroscopy NMR
;
SPR
;
surface plasmon resonance
;
TSA
;
thermal shift assay
;
N5-CAIR
;
N5-carboxyaminoimidazole ribonucleotide
;
CAIR
;
4-carboxyaminoimidazole ribonucleotide
;
AIR
;
aminoimidazole ribonucleotide
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
8.
Discovery
of potent, reversible MetAP2 inhibitors via
fragment
based
drug
discovery
and structure
based
drug design—Part 2
作者:
Christopher McBride
a
;
;
Zacharia Cheruvallath
a
;
Mallareddy Komandla
a
;
Mingnam Tang
a
;
Pamela Farrell
b
;
J. David Lawson
c
;
Darin Vanderpool
b
;
Yiqin Wu
b
;
Douglas R. Dougan
d
;
Artur Plonowski
b
;
Corine Holub
b
;
Chris Larson
b
关键词:
Methionine aminopeptidase-2
;
MetAP2
;
Metalloprotease
;
Fragment
-
based
drug
discovery
;
FBDD
;
Structure-
based
drug design
;
SBDD
;
Pyrazolo[4
;
3-b]indoles
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
9.
Fragment
-
based
in silico screening of bromodomain
ligand
s
作者:
Dimitrios Spiliotopoulos
;
d.spiliotopoulos@bioc.uzh.ch" class="auth_mail" title="E-mail the corresponding author
;
Amedeo Caflisch
;
caflisch@bioc.uzh.ch" class="auth_mail" title="E-mail the corresponding author
刊名:Drug
Discovery
Today: Technologies
出版年:2016
10.
Enriching screening libraries with bioactive
fragment
space
作者:
Na Zhang
a
;
nanatonglei@bjut.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Hongtao Zhao
b
;
htzhao@lephar.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Fragment
library
;
CK2
;
Kinase inhibitors
;
Fragment
-
based
drug
discovery
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
1
2
3
4
5
6
7
8
9
按检索点细分(117)
题名(6)
关键词(10)
文摘(75)
按出版年细分(117)
2027年及以后(4)
2017年(2)
2016年(12)
2015年(6)
2013年(12)
2012年(11)
2011年(12)
2010年(10)
2009年(6)
2008年(6)
2007年(6)
2006年(3)
2005年(5)
2004年(5)
2003年(2)
2002年(3)
2001年(1)
2000年(2)
2000年及以前(9)
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via
email
.