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在“Elsevier电子期刊”中，命中：8条，耗时：0.023985 秒

在所有数据库中总计命中：1条

1.Prediction of drug-related cardiac adverse effects in humans-B: Use of QSAR programs for early detection of drug-induced cardiac toxicities

作者：Anna A. Frid ; Edwin J. Matthews

关键词：AERS ; BioEpisteme™ ; Clinical indication ; Drug-induced cardiac toxicity ; Drug-related adverse effect ; In silico ; Leadscope FDA Model Applier ; MC4PC ; Mechanism of action ; QSAR ; Quantitative structure– ; activity relationship ; SRS ; Therapeu

刊名：Regulatory Toxicology and Pharmacology

出版年：2010

2.Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models

作者：Joseph F. Contrera ; Naomi L. Kruhlak ; Edwin J. Matthews ; R. Daniel Benz

关键词：Carcinogenicity ; Discriminant analysis ; In silico ; Predictive toxicology ; Topological descriptors ; QSAR ; E-state ; Chemoinformatics ; Discriminant analysis ; Consensus prediction

刊名：Regulatory Toxicology and Pharmacology

出版年：2007

3.Improved in silico prediction of carcinogenic potency (TD50) and the risk specific dose (RSD) adjusted Threshold of Toxicological Concern (TTC) for genotoxic chemicals and pharmaceutical impurities

作者：Joseph F. Contrera ^{jfcontrera@verizon.net}

关键词：TTC ; Threshold of toxicological concern ; Genotoxic ; Mutagenic ; Impurities ; QSAR ; SAR ; TD50 ; Pharmaceuticals ; Food contact substances ; RSD ; Carcinogenicity

刊名：Regulatory Toxicology and Pharmacology

出版年：2011

4.A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals

作者：Edwin J. Matthews ; Naomi L. Kruhlak ; R. Daniel Benz ; Julian Ivanov ; Gilles Klopman ; Joseph F. Contrera

关键词：MC4PC ; Computational toxicology ; Developmental toxicity ; Dysmorphogenesis ; Predictive modeling ; Quantitative structure activity relationships (QSAR) ; Reproductive toxicity ; Reprotox ; Teratogenicity ; Weight of evidence

刊名：Regulatory Toxicology and Pharmacology

出版年：2007

5.Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract t

作者：Edwin J. Matthews ; Carling J. Ursem ; Naomi L. Kruhlak ; R. Daniel Benz ; David Aragoné ; s Sabaté ; Chihae Yang ; Gilles Klopman ; Joseph F. Contrera

关键词：AERS ; Computational toxicology ; Drug adverse effects ; Drug-induced liver injury ; Drug-induced renal toxicity ; In silico ; Post-market reporting ; Quantitative structure-activity relationships ; QSAR software ; SAR ; SRS

刊名：Regulatory Toxicology and Pharmacology

出版年：2009

6.S18: In silico

作者：Susanne Glowienke

刊名：Experimental and Toxicologic Pathology

出版年：2009

7.An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods

作者：Edwin J. Matthews ; Naomi L. Kruhlak ; Michael C. Cimino ; R. Daniel Benz and Joseph F. Contrera

关键词：MC4PC ; Computational toxicology ; Quantitative structure– ; activity relationships ; Predictive modeling ; Genetic toxicity ; Genetox ; Reproductive and developmental toxicity ; Reprotox ; Carcinogenicity ; Rodent carcinogenicity bioassay ; Surrogate

刊名：Regulatory Toxicology and Pharmacology

出版年：2006

8.Structure??????activity considerations and in vitro approaches to assess the genotoxicity of 19 methane-, benzene- and toluenesulfonic acid esters

作者：Glowienke ; Susanne ; Frieauff ; Wilfried ; Allmendinger ; Thomas ; Martus ; Hans-Joerg ; Suter ; Willi ; et. al.

关键词：Sulfonic acid esters ; Genotoxicity ; Structure??????activity relationship ; MCASE ; Ames test ; Micronucleus test

刊名：Mut.Res.-Genetic Toxicology and Environmental Mutagenesis

出版年：2005

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