搜索页_ 17β-HSD1 inhibition

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知网期刊论文(6)

在“Elsevier电子期刊”中，命中：6条，耗时：0.0179941 秒

在所有数据库中总计命中：29条

1.Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

作者：Lukas Hroch^a ; ^b ; Patrick Guest^c ; Ondrej Benek^b ; ^d ; Ondrej Soukup^b ; Jana Janockova^b ; Rafael Dolezal^b ; ^d ; ^e ; Kamil Kuca^b ; ^d ; Laura Aitken^c ; Terry K. Smith^c ; Frank Gunn-Moore^c ; Dominykas Zala^c ; Rona R. Ramsay^c ; ; Kamil Musilek^b ; ^d ; ^{kamil.musilek@gmail.com}

关键词：Alzheimer's disease (AD) ; Monoamine oxidase (MAO) ; Amyloid-beta peptide (Aβ) ; Mitochondrial amyloid-binding alcohol dehydrogenase (ABAD) ; 17β-Hydroxysteroid dehydrogenase type 10 (17β-HSD10) ; Horseradish peroxidase (HRP)

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1)

作者：Wanhong He^a ; Misra Gauri^b ; Tang Li^c ; Ruixuan Wang^c ; Sheng-Xiang Lin^a ; ^c ;

关键词：17β-HSD1 ; 17β-hydroxysteroid dehydrogenase type 1 ; E1 ; Estrone ; E2 ; Estradiol ; 4-Adione ; 4-androstenedione ; SDR ; short-chain dehydrogenase/reductase family ; AKR ; aldo-keto-reductase ; SUB ; substrate binding site ; NSCLC ; non-small cell lung carcinomas ; AI ; aromatase inhibitor ; COF ; cofactor binding site ; OVX ; ovariectomized

刊名：Gene

出版年：2016

3.Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment

作者：Lukas Hroch^a ; ^b ; ^&dagger ; ; Ondrej Benek^b ; ^c ; ^&dagger ; ; Patrick Guest^d ; ^&dagger ; ; Laura Aitken^d ; ^&dagger ; ; Ondrej Soukup^b ; Jana Janockova^b ; Karel Musil^b ; ^f ; Vlastimil Dohnal^f ; Rafael Dolezal^b ; ^e ; Kamil Kuca^b ; ^f ; Terry K Smith^g ; Frank Gunn-Moore^d ; Kamil Musilek^b ; ^f ; ^{kamil.musilek@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer&rsquo ; s disease (AD) ; Amyloid-beta peptide (Aβ) ; Mitochondria ; Amyloid binding alcohol dehydrogenase (ABAD) ; 17β-Hydroxysteroid dehydrogenase type 10 (17β-HSD10) ; Benzothiazole ; Riluzole

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

作者：René ; Maltais^a ; ^b ; Alexandre Trottier^a ; ^b ; Xavier Barbeau^c ; ^d ; Patrick Lagü ; e^d ; ^e ; Martin Perreault^a ; ^b ; Jean-Franç ; ois Thé ; riault^a ; ^b ; Sheng-Xiang Lin^a ; ^b ; Donald Poirier^a ; ^b ; ^{donald.poirier@crchul.ulaval.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：Steroid ; Enzyme inhibitor ; Estrogen ; Chemical synthesis ; Estradiol isomer

刊名：Journal of Steroid Biochemistry and Molecular Biology

出版年：2016

5.Atrazine activates multiple signaling pathways enhancing the rapid hCG-induced androgenesis in rat Leydig cells

作者：Kristina Pogrmic-Majkic¹ ; Svetlana Fa¹ ; Dragana Samardzija ; Jelena Hrubik ; Sonja Kaisarevic ; Nebojsa Andric ; ^{nebojsa.andric@dbe.uns.ac.rs" class="auth_mail" title="E-mail the corresponding author} (Ph.D.)

关键词：22-OH cholesterol ; 22(R)-hydroxycholesterol ; cAMP ; 3&prime ; -5&prime ; -cyclic adenosine monophosphate ; CYP11A1 ; cytochrome P450C11A1 ; CYP17A1 ; cytochrome P450C17A1 ; ATR ; atrazine ; EGFR ; epidermal growth factor receptor ; hCG ; human chorionic gonadotropin ; HSD17β ; 17β-hydroxysteroid dehydrogenase ; HSD3β ; 3β-hydroxysteroid dehydrogenase ; LH ; luteinizing hormone ; LHR ; luteinizing hormone receptor ; NAC ; N-acetyl-l-cysteine ; PDE ; phosphodiesterase ; PKA ; protein kinase A ; PKC ; protein kinase C ; ROS ; reac

刊名：Toxicology

出版年：2016

6.Synthesis of A-ring halogenated 13α-estrone derivatives as potential 17β-HSD1 inhibitors

作者：Ildikó ; Bacsa^a ; Rebeka Jó ; já ; rt^a ; Gyula Schneider^a ; Já ; nos Wö ; lfling^a ; Pé ; ter Maró ; ti^a ; Bianka Edina Herman^b ; Mihá ; ly Szé ; csi^b ; ^{szecsi.mihaly@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Erzsé ; bet Mernyá ; k^a ; ^{bobe@chem.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：13α-Estrone ; Electrophilic halogenation ; Chemoselectivity ; Regioselectivity ; 17β-HSD1 inhibition

刊名：Steroids

出版年：2015

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