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在“Elsevier电子期刊”中，命中：43条，耗时：0.010963 秒

1.Significance of integrated in silico transmural ventricular wedge preparation models of human non-failing and failing hearts for safety evaluation of drug candidates

作者：Taeko Kubo ; DVM ; PhD^a ; ^b ; ^c ; ^{taeko-kubo@ds-pharma.co.jp} ; ^{taekok2016@gmail.com} ; Takashi Ashihara ; MD ; PhD^b ; Tadashi Tsubouchi ; PhD^a ; Minoru Horie ; MD ; PhD^b

关键词：AP ; action potential ; APD ; action potential duration ; APD30 ; APD at 30% repolarization ; APD90 ; APD at 90% repolarization ; APD30&ndash ; 90 ; APD90&ndash ; APD30 ; [Ca2 ; +]i ; intracellular Ca2 ; + concentration ; CiPA ; Comprehensive in vitro Proarrhythmia Assay ; CV ; conduction velocity ; EAD ; early afterdepolarization ; ECG ; electrocardiogram ; Endo ; endocardial ; Epi ; epicardial ; FH ; failing heart ; ICH ; International Conference of Harmonization ; IQ-CSRC ; Innovation and Quality in Pharmaceutical Deve

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

2.Enhanced effect of VEGF165 on L-type calcium currents in guinea-pig cardiac ventricular myocytes

作者：Wenlu Xing^a ; Chuanyu Gao^a ; ^{gaocy6208@163.com} ; Datun Qi^a ; ^c ; You Zhang^b ; Peiyuan Hao^a ; Guoyou Dai^a ; Ganxin Yan^a ; ^c

关键词：VEGF ; vascular endothelial growth factor ; LTCC ; L-type calcium channel ; VEGFR2 ; VEGF type-2 receptor ; ICaL ; L-type calcium currents ; AP ; action potential ; APD ; action potential duration ; EC coupling ; excitation-contraction coupling ; IV ; current-voltage

刊名：Biomedicine & Pharmacotherapy

出版年：2017

3.Experimental evidence for a severe proarrhythmic potential of levosimendan

作者：Gerrit Frommeyer^a ; ^{gerrit.frommeyer@ukmuenster.de} ; Anja Kohnke^a ; Christian Ellermann^a ; Dirk G. Dechering^a ; Simon Kochhä ; user^a ; Christian Pott^a ; Michael Fehr^b ; Lars Eckardt^a

关键词：Levosimendan ; Therapeutic safety ; Ventricular refractory period ; Ventricular fibrillation

刊名：International Journal of Cardiology

出版年：2017

4.The positive frequency-dependent electrophysiological effects of the I_Kur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

作者：John Ford ; PhD^* ; James Milnes ; PhD^* ; Said El Haou ; PhD^* ; Erich Wettwer ; PhD^&dagger ; ; Simone Loose ; MD^&dagger ; ; Klaus Matschke ; MD^&Dagger ; ; Benoit Tyl ; MD^§ ; ; Patrick Round ; MBBS^* ; Ursula Ravens ; MD^&dagger ; ; ^{ravens@rcs.urz.tu-dresden.de" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; ANOVA ; analysis of variance ; AP ; action potential ; APA ; action potential amplitude ; APD20 ; APD50 ; APD90 ; action potential duration at 20% ; 50% ; and 90% of repolarization ; cAF ; chronic atrial fibrillation ; DMSO ; dimethyl sulfoxide ; dV/dtmax ; maximum upstroke velocity ; ECG ; electrocardiogram/electrocardiographic ; ERP ; effective refractory period ; HR ; heart rate ; IKur ; ultra-rapidly activating delayed-rectifier potassium current ; pAF ; paroxysmal atrial fibrillation ; PLT20

刊名：Heart Rhythm

出版年：2016

5.Sarcolemmal Ca²⁺-entry through L-type Ca²⁺ channels controls the profile of Ca²⁺-activated Cl⁻ current in canine ventricular myocytes

作者：Balá ; zs Horvá ; th^a ; ^b ; ¹ ; Krisztina Vá ; czi^a ; ¹ ; Bence Hegyi^a ; Mó ; nika Gö ; nczi^a ; ^c ; Beatrix Dienes^a ; Korné ; l Kistamá ; s^a ; Tamá ; s Bá ; nyá ; sz^a ; Já ; nos Magyar^a ; ^d ; Istvá ; n Baczkó ; ^e ; Andrá ; s Varró ; ^e ; ^f ; Gyö ; rgy Sepré ; nyi^g ; Lá ; szló ; Csernoch^a ; Pé ; ter P. Ná ; ná ; si^a ; ^h ; Norbert Szentandrá ; ssy^a ; ^h ; ^{szentandrassy.norbert@med.unideb.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：9-AC ; 9-anthracene carboxylic acid ; AP ; action potential ; APVC ; action potential voltage-clamp ; APD90 ; action potential duration at 90% of repolarization ; BKCa ; large-conductance Ca2+-activated K+ channels ; CaT ; calcium transient ; Cav1.2 ; pore forming subunit of L-type Ca2+ channel ; [Ca2+]cleft ; Ca2+ concentration in the dyadic cleft ; [Ca2+]i ; intracellular Ca2+ concentration in bulk cytoplasm ; [Cl&minus ; ]i ; intracellular Cl&minus ; concentration ; CDI ; Ca2+-dependent inactivation ; CICR ; Ca2+-indu

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

6.Human ex-vivo action potential model for pro-arrhythmia risk assessment

作者：Guy Page^a ; Phachareeya Ratchada^a ; Yannick Miron^a ; Guido Steiner^b ; Andre Ghetti^a ; Paul E. Miller^a ; Jack A. Reynolds^a ; Ken Wang^b ; Andrea Greiter-Wilke^b ; Liudmila Polonchuk^b ; Martin Traebert^c ; Gary A. Gintant^d ; Najah Abi-Gerges^a ; ^{Najah.abigerges@anabios.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Human heart ; Ventricular trabeculae ; Action potential ; Pro-arrhythmia assessment ; Drug discovery and development

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

7.In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

作者：Lucia Romero^a ; ^{lurope@eln.upv.es" class="auth_mail" title="E-mail the corresponding author} ; Beatriz Trenor^a ; ^{btrenor@eln.upv.es" class="auth_mail" title="E-mail the corresponding author} ; Pei-Chi Yang^b ; ^{pcyang@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author} ; Javier Saiz^a ; ^{jsaiz@gbio.i3bh.es" class="auth_mail" title="E-mail the corresponding author} ; Colleen E. Clancy^b ; ^{ceclancy@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：aLQTS ; drug-induced or acquired long-QT syndrome ; AP ; action potential ; APD ; action potential duration ; APD90 ; action potential duration at 90% repolarization ; C1 ; closed state 1 ; C2 ; closed state 2 ; C3 ; closed state 3 ; EAD ; early-afterdepolarization ; ECG ; electrocardiogram ; I ; inactivated state ; IKr ; rapid component of the delayed rectifier current ; LQTS ; long-QT syndrome ; O ; open state ; RFI ; recovery from inactivation ; TdP ; torsade de pointes ; WT ; wild-type ; Actilide_Oc ; drug binding simultane

刊名：Journal of Molecular and Cellular Cardiology

出版年：2015

8.CiPA: Ongoing testing, future qualification procedures, and pending issues

作者：Icilio Cavero^a ; ^{iciliocavero@aol.com" class="auth_mail" title="E-mail the corresponding author} ; Henry Holzgrefe^b

关键词：AERS ; adverse event reporting system ; AP ; action potential ; APD ; action potential duration ; APD50 ; Action Potential Duration at 50% depolarization ; APD90 ; Action Potential Duration at 90% depolarization ; BP ; Beating Period ; BR ; Beating Rate or Rhythm ; Ca50 ; calcium transient amplitude at 50% of maximal activation ; Ca90 ; calcium transient amplitude at 90% of maximal activation ; CiPA ; comprehensive in vitro proarrhythmia assay ; CDER ; Center for Drug Evaluation and Research ; CTWG ; Clinical Translat

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2015

9.GW26-e4774 β1-adrenoceptor autoantibodies increase susceptibility to ventricular arrhythmias by shortening effective refractory period and prolonging MAPD90-30 in guinea pigs

刊名：Journal of the American College of Cardiology

出版年：2015

10.The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT

作者：Asma Mechakra ; Yohann Vincent ; Philippe Chevalier ; Gilles Millat ; Eckhard Ficker ; Marek Jastrzebski ; Hugo Poulin ; Val茅rie Pouliot ; Mohamed Chahine ; Georges Christ茅

关键词：APD ; Action potential duration ; APD90 ; APD at 90% repolarization ; DNA ; Deoxyribonucleic acid ; cDNA ; Cyclic DNA ; ECG ; Electrocardiogram ; ESP ; Exome Sequencing Project ; HEK293 ; Human-derived renal epithelial cell line number 293 ; hERG ; Human ether-à ; -go-go related gene ; IKr ; The rapid delayed rectifier current ; underlied in cardiac cells by hERG ; LQTS ; Long QT syndrome ; PAS domain ; Per-Arnt-Sim domain in the N-terminal branch of the hERG protein ; QT ; The QT interval of the ECG ; QTc ; The corr

刊名：Gene

出版年：25 February, 2014

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