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在“Elsevier电子期刊”中，命中：630条，耗时：小于0.01 秒

在所有数据库中总计命中：467条

1.The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABA_B receptor with a potential for treatment of anxiety, pain and spasticity

作者：Mikhail Kalinichev ; ^{mikhail.kalinichev@ipsen.com} ; Franç ; oise Girard ; Hasnaà ; Haddouk ; Mé ; lanie Rouillier ; Eric Riguet ; Isabelle Royer-Urios ; Vincent Mutel ; Robert Lü ; tjens ; Sonia Poli

关键词：Allosteric modulator ; GABA ; Anxiety ; Pain ; Body temperature ; Baclofen ; Spasticity ; Clinical candidate

刊名：Neuropharmacology

出版年：2017

2.3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats

作者：Agnieszka Potasiewicz^a ; Małgorzata Hołuj^a ; Tomasz Kos^a ; Piotr Popik^a ; Hugo R. Arias^b ; Agnieszka Nikiforuk^a ; ^{nikifor@if-pan.krakow.pl}

关键词：α7 Nicotinic acetylcholine receptors ; Positive allosteric modulator ; Animal model of schizophrenia ; Cognitive flexibility ; Recognition memory ; Antipsychotics

刊名：Neuropharmacology

出版年：2017

3.Challenges in the development of an M₄ PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

作者：Michael R. Wood^a ; ^c ; ¹ ; Meredith J. Noetzel^a ; ^b ; ¹ ; Michael S. Poslusney^a ; ¹ ; Bruce J. Melancon^a ; ^b ; James C. Tarr^a ; Atin Lamsal^a ; Sichen Chang^a ; Vincent B. Luscombe^a ; ^b ; Rebecca L. Weiner^a ; ^b ; Hyekyung P. Cho^a ; ^b ; Michael Bubser^a ; Carrie K. Jones^a ; ^b ; ^e ; Colleen M. Niswender^a ; ^b ; ^e ; Michael W. Wood^d ; Darren W. Engers^a ; ^b ; Nicholas J. Brandon^d ; Mark E. Duggan^d ; P. Jeffrey Conn^a ; ^b ; ^e ; Thomas M. Bridges^a ; ^b ; ^{thomas.m.bridges@vanderbilt.edu} ; Craig W. Lindsley^a ; ^b ; ^c ; ^{craig.lindsley@vanderbilt.edu}

关键词：M4 ; Muscarinic acetylcholine receptor ; Positive allosteric modulator (PAM) ; Schizophrenia ; Structure-activity relationship (SAR)

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors

作者：Akash Pandhare^a ; ^b ; ^{akash.pandhare@ttuhsc.edu} ; Aneesh Satya Pappu^a ; ^e ; ¹ ; ^{apappu@standford.edu} ; Henrik Wilms^c ; ^{henrik.wilms@ttuhsc.edu} ; Michael Paul Blanton^b ; ^d ; ^{michael.blanton@ttuhsc.edu} ; Michaela Jansen^a ; ^b ; ^{michaela.jansen@ttuhsc.edu}

关键词：Antidepressant ; Bupropion ; Hydroxybupropion ; 5-HT3A receptors ; Pentameric ligand-gated ion channels

刊名：Neuropharmacology

出版年：2017

5.Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine

作者：Bing Xue^a ; Elton C. Chen^b ; Nan He^a ; Dao-Zhong Jin^a ; Li-Min Mao^a ; John Q. Wang^a ; ^b ; ^c ; ^{wangjq@umkc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：D1 ; D2 ; Muscarinic receptor ; S845 ; Protein kinase A ; Caudate putamen ; Nucleus accumbens ; Positive allosteric modulator

刊名：Neuropharmacology

出版年：2017

6.The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptors

作者：Maria C. Olianas ; ^{molianas@unica.it} ; Simona Dedoni ; Pierluigi Onali

关键词：CGP7930 (PubChem CID ; 5024764) ; GS39783 (PubChem CID ; 6604928) ; (-)-baclofen (PubChem CID ; 44602) ; SKF97541 (PubChem CID ; 5230) ; CGP55845 (PubChem CID ; 5311042) ; CGP54626 (PubChem CID ; 197584) ; phorbol 12-myristate 13 acetate (PubChem CID ; 27924) ; Go 6850 (PubChem CID ; 2396) ; 5Z-7-oxozeaenol (PubChem CID ; 9863776) ; GW5074 (PubChem CID ; 5924208)

刊名：European Journal of Pharmacology

出版年：2017

7.Triazolopyridine ethers as potent, orally active mGlu₂ positive allosteric modulators for treating schizophrenia

作者：Mendi A. Higgins ; ^{mendi.higgins@bms.com} ; Lawrence R. Marcin ; F. Christopher Zusi ; Robert Gentles ; Min Ding ; Bradley C. Pearce ; Amy Easton ; Walter A. Kostich ; Matthew A. Seager ; Clotilde Bourin ; Linda J. Bristow ; Kim A. Johnson ; Regina Miller ; John Hogan ; Valerie Whiterock ; Michael Gulianello ; Meredith Ferrante ; Yanling Huang ; Adam Hendricson ; Andrew Alt ; John E. Macor ; Joanne J. Bronson

关键词：Schizophrenia ; mGlu2 ; Metabotropic glutamate receptors ; Triazolopyridine

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

8.X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT

作者：Sid Topiol^a ; ^{sid.topiol@3D-2drug.com} ; Benny Bang-Andersen^b ; Connie Sanchez^c ; Per Plenge^d ; Claus J. Loland^d ; Karsten Juhl^b ; Krestian Larsen^b ; Peter Bregnedal^e ; Klaus P. Bø ; gesø ; ^e

关键词：SERT ; serotonin transporter ; DAT ; dopamine transporter ; NAT ; noradrenaline transporter ; NSS ; neurotransmitter ; sodium symporter ; SSRI ; selective serotonin reuptake inhibitor ; TCA ; tricyclic antidepressant ; dDAT ; Drosophila melanogaster DAT ; LeuT ; leucine transporter

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

9.Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[¹¹C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([¹¹C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain

作者：Yufei Ma^a ; ^b ; ¹ ; Katsushi Kumata^a ; ¹ ; Joji Yui^a ; Yiding Zhang^a ; Tomoteru Yamasaki^a ; Akiko Hatori^a ; Masayuki Fujinaga^a ; Nobuki Nengaki^a ; Lin Xie^a ; Hui Wang^b ; Ming-Rong Zhang^a ; ^{zhang.ming-rong@qst.go.jp}

关键词：[11C]CMDC ; In vitro autoradiography ; Metabotropic glutamate receptor 2 ; Positron emission tomography ; Radiotracer ; Schizophrenia

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

10.Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT₃ receptors

作者：Agnes Gasiorek^a ; Sarah M. Trattnig^a ; Philip K. Ahring^b ; ¹ ; Uffe Kristiansen^a ; Bente Frø ; lund^a ; Kristen Frederiksen^c ; Anders A. Jensen^a ; ^{aaj@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author}

关键词：Cys-loop receptor ; 5-HT3 receptor ; Allosteric agonist ; Allosteric modulation ; Ago-PAM ; TMPPAA

刊名：Biochemical Pharmacology

出版年：2016

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