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内部出版物
CNKI学位论文(70)
知网期刊论文(45)
在“
Elsevier电子期刊
”中,
命中:
118
条,耗时:小于0.01 秒
在所有数据库中总计命中:
115
条
1.
Benzenesulphonamide inhibitors of the cytolytic protein perforin
作者:
Julie A. Spicer
a
;
b
;
j.spicer@auckland.ac.nz
;
Christian K. Miller
a
;
b
;
Patrick D. O'Connor
a
;
b
;
Jiney Jose
a
;
b
;
Kristiina M. Huttunen
a
;
c
;
Jagdish K. Jaiswal
a
;
b
;
William A. Denny
a
;
b
;
Hedieh Akhlaghi
d
;
Kylie A. Browne
d
;
Joseph A. Trapani
d
;
e
关键词:
Perforin
;
Perforin inhibitor
;
Benzenesulphonamide
;
Bioisostere
;
Immunosuppressant
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
2.
Squarate-based carbocyclic nucleosides: Syntheses, computational analyses and anticancer/antiviral evaluation
作者:
Meijun Lu
a
;
b
;
Qing-Bin Lu
b
;
John F. Honek
a
;
jhonek@uwaterloo.ca
关键词:
Squaric acid
;
Carbocyclic
;
Nucleoside
;
Anticancer
;
Antiviral
;
Bioisostere
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
3.
Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation
作者:
Nader N. Nasief
a
;
b
;
nnnasief@yahoo.com
;
Ahmed M. Said
a
;
c
;
David Hangauer
a
;
hangauer@buffalo.edu
关键词:
Thrombin
;
Protein-ligand binding
;
Desolvation
;
Bioisosterism
;
Hydrogen bond
;
Cooperativity
;
Nonadditivity
;
B3LYP/6-31G&lowast
刊名:European Journal of Medicinal Chemistry
出版年:2017
4.
Ligand binding cooperativity:
Bioisosteric
replacement
of CO with SO
2
among thrombin inhibitors
作者:
Ahmed M. Said
a
;
b
;
ahmedmoh@buffalo.edu" class="auth_mail" title="E-mail the corresponding author
;
David G. Hangauer
a
;
hangauer@buffalo.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Ligand&ndash
;
protein binding
;
Cooperativity
;
Nonadditivity
;
Bioisosteric
replacement
;
Hydrogen bonding
;
Hydrophobic binding
;
Thrombin
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
5.
Core chemotype diversification in the HIV-1 entry inhibitor class using field-based
bioisosteric
replacement
作者:
Marina Tuyishime
a
;
Rae Lawrence
b
;
Simon Cocklin
a
;
scocklin@drexelmed.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Computer-aided drug design
;
HIV-1 envelope protein
;
Field-based
;
Bioisosteric
replacement
;
Scaffold-hopping
;
SAR analysis
;
Structure&ndash
;
activity landscape
;
Antiviral
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
6.
Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author
;
Alexey Lukin
b
;
Nikolay Zhurilo
b
;
Alexey Kovalenko
b
;
Ihor Zahanich
c
;
Sergey Zozulya
c
;
d
;
Daniel Moore
e
;
Irina G. Tikhonova
e
关键词:
GPR40
;
Free fatty acid receptor 1
;
FFA1 agonists
;
Bioisosteric
replacement
;
Total polar surface area
;
c
;
Log
P ;
Metabolic stability
;
Aqueous solubility
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
7.
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors
作者:
Dmitri A. Pissarnitski
a
;
;
Zhiqiang Zhao
a
;
David Cole
a
;
Wen-Lian Wu
a
;
Martin Domalski
a
;
John W. Clader
a
;
Giovanna Scapin
b
;
Johannes Voigt
b
;
&dagger
;
;
Aileen Soriano
c
;
Theresa Kelly
c
;
Mary Ann Powles
d
;
Zuliang Yao
d
;
Duane A. Burnett
a
;
&Dagger
;
关键词:
Bioisosteres
;
Tricyclic guanine
;
DPP4 inhibitor
;
FAP inhibitor
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
8.
Novel indole sulfides as potent HIV-1 NNRTIs
作者:
Siobhan Brigg
a
;
Nicole Pribut
a
;
Adriaan E. Basson
b
;
Moscos Avgenikos
a
;
Reinhardt Venter
a
;
Margaret A. Blackie
a
;
Willem A.L. van Otterlo
a
;
Stephen C. Pelly
a
;
scpelly@sun.ac.za" class="auth_mail" title="E-mail the corresponding author
关键词:
HIV
;
NNRTI
;
Indole
;
Sulfides
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
9.
Quinoxalinone (Part II). Discovery of (Z)-3-(2-(pyridin-4-yl)vinyl)quinoxalinone derivates as potent VEGFR-2 kinase inhibitors
作者:
Leilei Shi
a
;
Jianfeng Zhou
b
;
Jifeng Wu
c
;
Junya Cao
d
;
Yuemao Shen
a
;
Hua Zhou
e
;
Xun Li
a
;
tjulx2004@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
VEGFR-2 inhibitor
;
Quinoxalinone derivates
;
Antiangiogenesis
;
Pyridyl motif
;
Activity evaluation
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
10.
Design and synthesis of novel androgen receptor antagonists via molecular modeling
作者:
Chao Zhao
;
You Hee Choi
;
Daulat Bikram Khadka
;
Yifeng Jin
;
Kwang-Youl Lee
;
kwanglee@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
;
Won-Jea Cho
;
wjcho@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
关键词:
AR antagonist
;
Molecular modeling
;
Bioisostere
;
Nicotinamide
;
Pyrazinamide
;
Pyrimidinamide
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
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