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在“Elsevier电子期刊”中，命中：16条，耗时：小于0.01 秒

1.Mitigation of reactive metabolite formation for a series of 3-amino-2-pyridone inhibitors of Bruton’s tyrosine kinase (BTK)

作者：Yan Lou ; ^{yan.lou@gmail.com} ; Francisco Lopez ; Yongying Jiang ; Xiaochun Han ; Chris Brotherton ; Roland Billedeau ; Steve Gabriel ; Shelly Gleason ; David M. Goldstein ; Ramona Hilgenkamp ; Buelent Kocer ; Lucja Orzechowski ; Jenny Tan ; Peter Wovkulich ; Bo Wen ; David Fry ; Paola Di Lello ; Lucy Chen ; Fang-jie Zhang ; Jennifer Fretland ; Anjali Nangia ; Tian Yang ; Timothy D. Owens

关键词：Bruton&rsquo ; s tyrosine kinase ; BTK ; Reactive metabolite ; Covalent binding ; Glutathione adduct

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Front-line treatment of CLL in the era of novel agents

作者：Tadeusz Robak^a ; ^{robaktad@csk.umed.lodz.pl} ; Stephan Stilgenbauer^b ; ^{Stephan.Stilgenbauer@uniklinik-ulm.de} ; Alessandra Tedeschi^c ; ^{alessandra.tedeschi@ospedaleniguarda.it}

关键词：Chronic lymphocytic leukaemia ; First-line ; Bruton&rsquo ; s kinase inhibitor ; Ibrutinib ; Elderly ; PI3Kδ inhibitor ; Idelalisib ; Venetoclax

刊名：Cancer Treatment Reviews

出版年：2017

3.Indirect Treatment Comparisons of Ibrutinib Versus Physician’s Choice and Idelalisib Plus Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia

作者：Sonja Sorensen ; MPH¹ ; ^{Sonja.sorensen@evidera.com} ; Mark Wildgust ; PhD² ; Nishan Sengupta ; PhD³ ; Cristina Trambitas ; MBA⁴ ; Joris Diels ; PhD⁵ ; Suzy van Sanden ; PhD⁵ ; Yingxin Xu ; PharmD ; PhD⁶ ; Emily Dorman ; MPH ; MBA¹

关键词：chronic lymphocytic leukemia ; ibrutinib ; idelalisib ; ofatumumab ; indirect treatment comparison

刊名：Clinical Therapeutics

出版年：2017

4.Discovery of highly potent and selective Bruton’s tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

作者：Wendy B. Young^a ; ; James Barbosa^b ; Peter Blomgren^b ; Meire C. Bremer^a ; James J. Crawford^a ; Donna Dambach^a ; Charles Eigenbrot^a ; Steve Gallion^c ; Adam R. Johnson^a ; Jeffrey E. Kropf^b ; Seung H. Lee^b ; Lichuan Liu^a ; Joseph W. Lubach^a ; Jen Macaluso^b ; Pat Maciejewski^b ; Scott A. Mitchell^b ; Daniel F. Ortwine^a ; Julie Di Paolo^b ; Karin Reif^a ; Heleen Scheerens^a ; Aaron Schmitt^b ; Xiaojing Wang^a ; Harvey Wong^a ; Jin-Ming Xiong^b ; Jianjun Xu^b ; Christine Yu^a ; Zhongdong Zhao^b ; Kevin S. Currie^b

关键词：Kinase inhibitor ; Bruton&rsquo ; s tyrosine kinase (BTK) ; Rheumatoid arthritis ; Pyridazinone

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Approaching the active conformation of 1,3-diaminopyrimidine based covalent inhibitors of Bruton’s tyrosine kinase for treatment of Rheumatoid arthritis

作者：Zhenhua Huang ; ^{kbp@kbpbiosciences.com" class="auth_mail" title="E-mail the corresponding author} ; Qian Zhang ; Lianzhong Yan ; Guizhen Zhong ; Linqi Zhang ; Xiaojuan Tan ; Yanli Wang

关键词：Bruton&rsquo ; s tyrosine kinase (BTK) ; Rheumatoid arthritis (RA) ; Collagen-induced arthritis (CIA) ; 1 ; 3-Diamino-pyrimidine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Une découverte fortuite et tardive de maladie de Bruton

作者：Pauline Treguier¹ ; ^{pauline.treguier@gmail.com} ; Aude Marie-Cardine² ; Pascale Schneider²

刊名：Revue d'Oncologie Hématologie Pédiatrique

出版年：2016

7.Structure-based discovery of novel 4,5,6-trisubstituted pyrimidines as potent covalent Bruton’s tyrosine kinase inhibitors

作者：Yi Zou^a ; ^&dagger ; ; Jianhu Xiao^a ; ^&dagger ; ; Zhengchao Tu^b ; ^&dagger ; ; Yingyi Zhang^a ; Kun Yao^a ; Minghao Luo^a ; Ke Ding^b ; ^{ding_ke@gibh.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Yihua Zhang^a ; Yisheng Lai^a ; ^{yslai@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：BTK ; Covalent kinase inhibitor ; Pyrimidine ; Structure&ndash ; activity relationship ; Molecular dynamics simulation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies

作者：Johannes J.M. Rood^a ; ^{j.j.m.rood@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Stephanie van Hoppe^b ; Alfred H. Schinkel^b ; Jan H.M. Schellens^a ; ^c ; Jos H. Beijnen^a ; ^c ; ^d ; Rolf W. Sparidans^a

关键词：BCR ; B-cell antigen receptor ; BSA ; bovine serum albumin ; BTK ; Bruton&rsquo ; s tyrosine kinase ; CHMP ; Committee for Medicinal Products for Human Use ; DHI ; dhihydrodiol-ibrutinib ; DMSO ; dimethyl Sulphoxide ; EMA ; European Medicines Agency ; ErbB2 ; receptor tyrosine-protein kinase erbB-2 ; ESI ; electro spray ionization ; FDA ; Food and Drug Administration ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; LLOQ ; lower limit of quantitation ; MRP1 ; multidrug resistance protein 1 ; PP ; pol

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

9.Enabling Effective Operational Decision Making on a Combined Heat and Power System Using the 5C Architecture

作者：Ken Bruton ; ^{k.bruton@ucc.ie" class="auth_mail" title="E-mail the corresponding author} ; Brendan P. Walsh ; Donal ó ; g Cusack ; Peter O&rsquo ; Donovan ; D.T.J. O'Sullivan

关键词：5C Architecture ; Cyber Physical Systems ; Smart Manufacturing ; Smart Grid ; Integrated Energy Systems

刊名：Procedia CIRP

出版年：2016

10.Mitigating the dual liability of newness and foreignness in capital markets: The role of returnee independent directors

作者：Weiwen Li^a ; ^{allenliweiwen@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Garry D. Bruton^a ; ^b ; ^{g.bruton@tcu.edub" class="auth_mail" title="E-mail the corresponding author} ; Igor Filatotchev^c ; ^d ; ^{Igor.Filatotchev@city.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：Returnee independent directors ; Liability of newness ; Liability of foreignness in capital markets ; Investor protection

刊名：Journal of World Business

出版年：2016

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