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内部出版物
在“
Elsevier电子期刊
”中,
命中:
27
条,耗时:小于0.01 秒
1.
Identification of novel nitroreductases from Bacillus cereus and their interaction with the
CB1954
prodrug
作者:
Vanessa V. Gwenin
;
Paramasivan Poornima
;
Jennifer Halliwell
;
Patrick Ball
;
George Robinson
;
Chris D. Gwenin
;
c.d.gwenin@bangor.ac.uk" class="auth_mail" title="E-mail the corresponding author
关键词:
Bacillus cereus
;
Nitroreductase
;
CB1954
;
Prodrug therapy
刊名:Biochemical Pharmacology
出版年:2015
2.
Structural basis of Escherichia coli nitroreductase NfsB triple mutants engineered for improved activity and regioselectivity toward the prodrug
CB1954
作者:
Jing Bai
a
;
Jun Yang
a
;
junyang@dlut.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Yong Zhou
b
;
Qing Yang
a
关键词:
Escherichia coli nitroreductase NfsB
;
CB1954
;
Protein engineering
;
X-ray structure
刊名:Process Biochemistry
出版年:2015
3.
Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria
作者:
Panos Lehouritis
a
;
1
;
Michael Stanton
a
;
1
;
Florence O. McCarthy
b
;
Matthieu Jeavons
a
;
Mark Tangney
a
;
m.tangney@ucc.ie" class="auth_mail" title="E-mail the corresponding author
关键词:
Cancer
;
Therapy
;
Targeting
;
Chemotherapy
;
GDEPT
刊名:Journal of Controlled Release
出版年:2016
4.
Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs
CB1954
and PR-104A
作者:
Gareth A. Prosser
a
;
Janine N. Copp
a
;
Alexandra M. Mowday
b
;
Christopher P. Guise
b
;
Sophie P. Syddall
b
;
Elsie M. Williams
a
;
Claire N. Horvat
a
;
Pearl M. Swe
a
;
Amir Ashoorzadeh
b
;
c
;
William A. Denny
b
;
c
;
Jeff B. Smaill
b
;
c
;
Adam V. Patterson
b
;
c
;
David F. Ackerley
a
;
c
;
d
;
david.ackerley@vuw.ac.nz
关键词:
CB1954
;
PR-104
;
Nitroreductase
;
Gene therapy
;
Nitroaromatic prodrug
;
SOS chromotest
刊名:Biochemical Pharmacology
出版年:2013
5.
Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug
CB1954
作者:
P.M. Swe
;
J.N. Copp
;
L.K. Green
;
C.P. Guise
;
A.M. Mowday
;
J.B. Smaill
;
A.V. Patterson
;
D.F. Ackerley
关键词:
CB1954
;
Nitroreductase
;
SOS response
;
Enzyme prodrug therapy
;
Directed evolution
刊名:Biochemical Pharmacology
出版年:2012
6.
Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug
CB1954
作者:
G.A. Prosser
;
J.N. Copp
;
S.P. Syddall
;
E.M. Williams
;
J.B. Smaill
;
W.R. Wilson
;
A.V. Patterson
;
D.F. Ackerley
关键词:
CB1954
;
Nitroreductase
;
SOS chromotest
;
GDEPT
;
Nitroaromatic prodrug
刊名:Biochemical Pharmacology
出版年:2010
7.
uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug
CB1954
作者:
G.A. Prosser
;
A.V. Patterson
;
D.F. Ackerley
关键词:
CB1954
;
Nitroreductase
;
SOS chromotest
;
uvrB
;
Nitroaromatic prodrug
;
Cancer gene therapy
刊名:Journal of Biotechnology
出版年:2010
8.
An unusually cold active nitroreductase for prodrug activations
作者:
Ayhan Ç
;
elik
;
ayhancelik@gyte.edu.tr
;
Gü
;
lden Yeti?
关键词:
Nitroreductase
;
Cold active enzyme
;
Prodrug activation
;
CB1954
;
Staphylococcus saprophyticus
;
Nitrofurazone
刊名:Bioorganic and Medicinal Chemistry
出版年:2012
9.
Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate
CB1954
作者:
Paul R. Race
;
Andrew L. Lovering
;
Scott A. White
;
Jane I. Grove
;
Peter F. Searle
;
Christopher W. Wrighton
;
EvaI. Hyde
关键词:
nitroreductase
;
CB1954
;
protein engineering
;
X-ray structure
;
gene therapy
刊名:Journal of Molecular Biology
出版年:2007
10.
Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations
作者:
Mansooreh Jaberipour
;
Simon O. Vass
;
Christopher P. Guise
;
Jane I. Grove
;
Richard J. Knox
;
Longqin Hu
;
Eva I. Hyde
;
Peter F. Searle
关键词:
Nitroreductase
;
Prodrugs
;
CB1954
(5-[(aziridin-1-yl]-2
;
4-dinitrobenzamide)
;
Virus directed enzyme prodrug therapy (VDEPT)
;
Cancer gene therapy
刊名:Biochemical Pharmacology
出版年:2010
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