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内部出版物
CNKI学位论文(279)
知网期刊论文(205)
在“
Elsevier电子期刊
”中,
命中:
97
条,耗时:0.0189868 秒
在所有数据库中总计命中:
484
条
1.
Inhibition of ATR-dependent feedback activation of
Chk1
sensitises cancer cells to Chk1 inhibitor monotherapy
作者:
Andrew J. Massey
a.massey@vernalis.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Chk1
;
ATR
;
ATM
;
DNA-PK
;
Kinase inhibitor
;
Replication stress
刊名:Cancer Letters
出版年:2016
2.
CHK1
and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?
作者:
Leonor M. Sarmento
;
Joã
;
o T. Barata
;
joao_barata@medicina.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author
关键词:
CHK1
;
Replicative stress
;
ATR
;
ATM
;
T-ALL
;
T-cell acute lymphoblastic leukemia
;
Targeted therapies
刊名:Advances in Biological Regulation
出版年:2016
3.
QSAR study of pyrazolo[1,5-a]pyrimidine derivative
inhibitors
of
Chk1
作者:
Jing Chen
;
jchen@nwnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Miao Zhang
;
Qing Ma
;
Dongdong Qin
;
Liping Zhang
;
Xiaoquan Lu
;
luxq@nwnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
Checkpoint kinase 1
;
Quantitative structure&ndash
;
activity relationship
;
Particle swarm optimization
;
Support vector machine
刊名:Chemometrics and Intelligent Laboratory Systems
出版年:2016
4.
mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to
Chk1
inhibition
作者:
Andrew J. Massey
a
;
a.massey@vernalis.com" class="auth_mail" title="E-mail the corresponding author
;
Peter Stephens
b
;
Rebecca Rawlinson
a
;
Lauren McGurk
b
;
Ruth Plummer
b
;
Nicola J. Curtin
b
;
nicola.curtin@ncl.ac.uk" class="auth_mail" title="E-mail the corresponding author
关键词:
Chk1
;
mTOR
;
DNA-PKcs
;
V158411
;
Double strand break repair
刊名:Molecular Oncology
出版年:2016
5.
Design and synthesis of 2-oxindole based multi-targeted
inhibitors
of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme
作者:
Simona Sestito
a
;
1
;
Giulia Nesi
a
;
1
;
Simona Daniele
a
;
Alma Martelli
a
;
Maria Digiacomo
a
;
Alice Borghini
b
;
Daniele Pietra
b
;
Vincenzo Calderone
a
;
Annalina Lapucci
a
;
Marco Falasca
c
;
Paola Parrella
d
;
Angelantonio Notarangelo
e
;
Maria C. Breschi
a
;
Marco Macchia
a
;
Claudia Martini
a
;
Simona Rapposelli
a
;
simona.rapposelli@farm.unipi.it" class="auth_mail" title="E-mail the corresponding author
关键词:
PDK1
inhibitors
;
Kinase
inhibitors
;
Oxindole derivatives
;
Glioblastoma
;
GBM stem cells
;
Multi-target therapy
刊名:European Journal of Medicinal Chemistry
出版年:2015
6.
CHEK again: Revisiting the development of
CHK1
inhibitors
for cancer therapy
作者:
S. McNeely
;
mcneely_samuel_clark@lilly.com" class="auth_mail
;
R. Beckmann
;
A.K. Bence Lin
关键词:
CHK1
;
Checkpoint kinase 1
;
DNA replication
;
WEE1
;
DNA damage response
刊名:Pharmacology and Therapeutics
出版年:April, 2014
7.
A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair
作者:
Naoaki Fujii
;
naoaki.fujii@stjude.org" class="auth_mail" title="E-mail the corresponding author
;
Benjamin J. Evison
;
Marcelo L. Actis
;
Akira Inoue
关键词:
ATM
;
Ataxia telangiectasia mutated
;
ATR
;
ATM and rad3-related
;
BCA
;
bicinchoninic acid
;
Chk1
;
checkpoint kinase 1
;
DDR
;
DNA damage response/repair
;
DMSO
;
dimethyl sulfoxide
;
EDTA
;
ethylenediaminetetraacetic acid
;
FBS
;
fetal bovine serum
;
HEPES
;
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
;
HR
;
homologous recombination
;
ICL
;
interstrand DNA crosslink
;
ICLR
;
ICL repair
;
MMR
;
mismatch repair
;
NER
;
nucleotide excision repair
;
PBS
;
phosphate-buffered saline
;
PAGE
;
polyacrylamide gel electr
刊名:Bioorganic & Medicinal Chemistry
出版年:2015
8.
Chk1
as a new therapeutic target in triple-negative breast cancer
作者:
Laurence Albiges
a
;
Aï
;
cha Goubar
b
;
Vé
;
ronique Scott
b
;
Cé
;
cile Vicier
b
;
Cé
;
line Lefè
;
bvre
b
;
Samar Alsafadi
b
;
Fré
;
dé
;
ric Commo
b
;
Mahasti Saghatchian
a
;
Vladimir Lazar
c
;
Philippe Dessen
c
;
Suzette Delaloge
a
;
b
;
Fabrice André
;
a
;
b
;
fabrice.andre@gustaveroussy.fr" class="auth_mail
;
Virginie Quidville
b
关键词:
Cell growth
;
Chk1
;
Mitotic catastrophe
;
Triple-negative breast cancer
刊名:The Breast
出版年:June 2014
9.
CHK1
levels correlate with sensitization to pemetrexed by CHK1
inhibitors
in non-small cell lung cancer cells
作者:
Svetlana Grabauskiene
;
Edward J. Bergeron
;
Guoan Chen
;
Andrew C. Chang
;
Jules Lin
;
Dafydd G. Thomas
;
Thomas J. Giordano
;
David G. Beer
;
Meredith A. Morgan
;
Rishindra M. Reddy
关键词:
CHK1
;
checkpoint kinase 1
;
LOH
;
loss of heterozygosity
;
NSCLC
;
non-small cell lung cancer
;
PMX
;
pemetrexed
;
RMA
;
Robust Multi-Array Average
刊名:Lung Cancer
出版年:December, 2013
10.
Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of
CHK1
inhibitors
作者:
Xiaohua Huang
a
;
xiaohua.huang@merck.com
;
Cliff C. Cheng
a
;
Thierry O. Fischmann
b
;
José
;
S. Duca
b
;
Matthew Richards
a
;
Praveen K. Tadikonda
a
;
Panduranga Adulla Reddy
a
;
Lianyun Zhao
a
;
M. Arshad Siddiqui
a
;
David Parry
c
;
Nicole Davis
c
;
Wolfgang Seghezzi
c
;
Derek Wiswell
c
;
Gerald W. Shipps Jr.
a
;
gshipps@comcast.net
关键词:
CHK1
protein kinase
;
2-Aminothiazole-4-carboxamide
;
Hybrid compounds
;
Structure-based drug design
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2013
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