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在“Elsevier电子期刊”中，命中：70条，耗时：小于0.01 秒

1.Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache

作者：Maria-Jesus Blanco^a ; ^{blanco_maria@lilly.com} ; Dana R. Benesh^a ; James A. Knobelsdorf^a ; Albert Khilevich^a ; Guillermo S. Cortez^a ; Fese Mokube^a ; Thomas D. Aicher^b ; Todd M. Groendyke^b ; Fredrik P. Marmsater^b ; Tony P. Tang^b ; Kirk W. Johnson^a ; Amy Clemens-Smith^a ; Mark A. Muhlhauser^a ; Steven Swanson^a ; John Catlow^a ; Renee Emkey^a ; Michael P. Johnson^a ; Jeffrey M. Schkeryantz^a

关键词：Allosteric modulators ; mGlu2 ; PAMs ; Metabotropic glutamate receptor ; CysLT1 ; Migraine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Preventive effect of genetic knockdown and pharmacological blockade of CysLT₁R on lipopolysaccharide (LPS)-induced memory deficit and neurotoxicity in vivo

作者：Fang Chen^a ; ¹ ; Arijit Ghosh^a ; ¹ ; ² ; Feng Wu^b ; Susu Tang^a ; Mei Hu^a ; Hongbin Sun^a ; Lingyi Kong^a ; Hao Hong^a ; ^{honghao@cpu.edu.cn}

关键词：Alzheimer&rsquo ; s disease ; Bcl-2/Bax ; Caspase-3 ; CysLT1R ; IL-1β ; Microglia ; NF-κB p65 ; Pranlukast ; shRNA ; TNF-α

刊名：Brain, Behavior, and Immunity

出版年：2017

3.CysLT₂ receptor activation is involved in LTC₄-induced lung air-trapping in guinea pigs

作者：Tomohiko Sekioka^a ; ^{sekioka@ono.co.jp} ; Michiaki Kadode^a ; Yasuo Yonetomi^a ; Akihiro Kamiya^a ; Manabu Fujita^a ; Takeshi Nabe^b ; Kazuhito Kawabata^a

关键词：Cysteinyl leukotrienes ; CysLT2 receptors ; CysLT1 receptors ; Asthma ; Air-trapping ; Bronchoconstriction

刊名：European Journal of Pharmacology

出版年：2017

4.CysLT₁R downregulation reverses intracerebroventricular streptozotocin-induced memory impairment via modulation of neuroinflammation in mice

作者：Arijit Ghosh^a ; ¹ ; ² ; Fang Chen^a ; ¹ ; Feng Wu^b ; Su-Su Tang^a ; Mei Hu^a ; Yan Long^a ; Hong-Bin Sun^a ; Ling-Yi Kong^a ; Hao Hong^a ; ^{honghao@cpu.edu.cn}

关键词：Cysteinyl leukotrienes receptor 1 ; Memory ; Neuroinflammation ; Pranlukast ; Stereotaxic injection ; STZ ICV

刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry

出版年：2017

5.6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer’s disease via CysLT1R-mediated inhibition of cathepsin B

作者：Ji-Young Na^a ; Kibbeum Song^a ; Ju-Woon Lee^b ; Sokho Kim^a ; ^{raios@hanmail.net" class="auth_mail" title="E-mail the corresponding author} ; Jungkee Kwon^a ; ^b ; ^{jkwon@jbnu.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：6-Shogaol ; Alzheimer&rsquo ; s disease ; Cysteinyl leukotriene 1 receptor ; Cathepsin B ; Ginger

刊名：Biochemical and Biophysical Research Communications

出版年：2016

6.Leukotriene D₄ and prostaglandin E₂ signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3

作者：Vinay Kondeti ; PhD^a ; Nosayba Al-Azzam ; MS^a ; Ernest Duah ; MS^a ; Charles K. Thodeti ; PhD^b ; Joshua A. Boyce ; MD^c ; ^d ; ^e ; Sailaja Paruchuri ; PhD^a ; ^{sp97@uakron.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Mast cells ; prostaglandin E2 ; leukotriene D4 ; CysLT1R ; E-prostanoid receptor 3 ; prostaglandin D2 ; c-fos ; protein kinase G ; extracellular signal-regulated kinase ; macrophage inflammatory protein 1β

刊名：Journal of Allergy and Clinical Immunology

出版年：2016

7.Cellular signalling of cysteinyl leukotriene type 1 receptor variants CysLT₁-G300S and CysLT₁-I206S

作者：Louiza Yaddaden^a ; Steeve Vé ; ronneau^a ; Miles D. Thompson^b ; Marek Rola-Pleszczynski^a ; Jana Stankova^a ; ^{jana.stankova@usherbrooke.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：cysLTs ; cysteinyl-leukotrienes ; CysLT1 ; cysteinyl-leukotriene type 1 receptor ; WT ; wild-type ; LT ; leukotriene ; GPCR ; G-protein-coupled receptor

刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids

出版年：2016

8.Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function

作者：Joseph M. Kulinski ^{joseph.kulinski@nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Rosa Muñ ; oz-Cano ^{munozcanorm@niaid.nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Ana Olivera ; ^{ana.olivera@nih.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：AA ; arachidonic acid ; ABCC1 ; ATP-binding cassette ; sub-family C ; BLT1-2 ; leukotriene B4 receptors 1 to 2 ; BMMC ; bone marrow derived mast cells ; COX ; cyclooxygenase ; Cys-LT ; cysteinyl leukotrienes ; CysLT1&ndash2 ; cysteinyl leukotriene receptors 1&ndash2 ; DP1-2 ; prostaglandin D2 receptors 1 to 2 ; FcεRI ; high affinity receptor for IgE ; GPCR ; G-protein coupled receptor ; KIT ; stem cell factor receptor ; 5-LO ; 5-lipoxygenase ; LTB4 ; leukotriene B4 ; LTC4 ; leukotriene C4 ; LTC4S ; leukotriene C4 synthase

刊名：European Journal of Pharmacology

出版年：2016

9.Renoprotective approaches and strategies in acute kidney injury

作者：Yuan Yang^a ; Meifang Song^a ; Yu Liu^a ; Hong Liu^a ; Lin Sun^a ; Youming Peng^a ; Fuyou Liu^a ; ^{lfy2061@163.com" class="auth_mail" title="E-mail the corresponding author} ; Manjeri A. Venkatachalam^b ; Zheng Dong^a ; ^c ; ^{zdong@augusta.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ACTH ; Adrenocorticotropic hormone ; AIF ; Apoptosis inducing factor ; AKI ; Acute kidney injury ; BMSC ; Bone marrow derived stem cells ; CIN ; Contrast-induced nephropathy ; COMP-Ang1 ; Cartilage oligomeric matrix protein-angiopoietin-1 ; CysLT1R ; Cysteinyl leukotriene-1 receptor ; DMARD ; Disease-modifying antirheumatic drugs ; eNOS ; Endothelial nitric oxide synthase ; eEPCs ; Endothelial progenitor cells ; HDAC ; Histone deacetylase ; HSPC ; Hematopoietic stem and progenitor cells ; IRI ; Ischemia&ndash ; reperfusio

刊名：Pharmacology and Therapeutics

出版年：2016

10.Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones

作者：Tonio Pera ^{tonio.pera@jefferson.edu" class="auth_mail" title="E-mail the corresponding author} ; Raymond B. Penn ; ^{raymond.penn@jefferson.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ASM ; airway smooth muscle ; AHR ; airway hyperresponsiveness ; β2AR ; beta 2 adrenergic receptor ; BTR ; bitter taste receptor ; CysLT1R ; cysteinyl leukotriene receptor 1 ; CaSR ; calcium sensing receptor ; EP ; prostanoid EP receptor ; GPCR ; G protein-coupled receptor ; M3 mAChR ; cholinergic M3 receptor ; OGR1 ; ovarian cancer G protein-coupled receptor 1 ; PAR ; protease-activated receptor ; PDE ; phosphodiesterase ; PKA ; protein kinase A

刊名：Pharmacology and Therapeutics

出版年：2016

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