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内部出版物
在“
Elsevier电子期刊
”中,
命中:
67
条,耗时:小于0.01 秒
1.
Dihydroorotate dehydrogenase: A drug target for the development of antimalarials
作者:
Anju Singh
;
Mudasir Maqbool
;
Mohammad Mobashir
;
Nasimul Hoda
;
nhoda@jmi.ac.in
关键词:
Malaria
;
Dihydroorotate dehydrogenase (
DHODH
)
;
Pyrimidine biosynthesis
;
Plasmodium parasite
;
Drug resistance
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
作者:
Luí
;
s Felipe S.P. Azeredo
a
;
b
;
Julia P. Coutinho
c
;
d
;
Valquiria A.P. Jabor
e
;
Patricia R. Feliciano
e
;
Maria Cristina Nonato
e
;
Carlos R. Kaiser
b
;
Carla Maria S. Menezes
a
;
Amanda S.O. Hammes
f
;
Ernesto Raul Caffarena
f
;
Lucas V.B. Hoelz
a
;
Nicolli B. de Souza
c
;
Glaé
;
cia A.N. Pereira
c
;
Isabela P. Cerá
;
volo
c
;
Antoniana U. Krettli
c
;
d
;
Nubia Boechat
a
;
b
;
boechat@far.fiocruz.br
关键词:
Malaria
;
P. falciparum
;
Pyrazolo[1
;
5-a]pyrimidine
;
Dihydroorotate dehydrogenase (
DHODH
)
;
Molecular docking
刊名:European Journal of Medicinal Chemistry
出版年:2017
3.
Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase
作者:
Daniel Ken Inaoka
a
;
b
;
Maiko Iida
c
;
Satoshi Hashimoto
c
;
Toshiyuki Tabuchi
c
;
Takefumi Kuranaga
c
;
Emmanuel Oluwadare Balogun
a
;
Teruki Honma
d
;
Akiko Tanaka
d
;
Shigeharu Harada
e
;
Takeshi Nara
f
;
Kiyoshi Kita
a
;
b
;
Masayuki Inoue
c
;
inoue@mol.f.u-tokyo.ac.jp
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
4.
A high-throughput fluorescence-based assay for Plasmodium dihydroorotate dehydrogenase inhibitor screening
作者:
Ivá
;
n Caballero
a
;
Marí
;
a José
;
Lafuente
b
;
Francisco-Javier Gamo
b
;
Concepció
;
n Cid
a
;
concha.cid@gsk.com" class="auth_mail" title="E-mail the corresponding author
;
conchacidcalzada@gmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
DHODH
;
Resazurin
;
Fluorescence
;
Assay development
;
HTS
;
Malaria
刊名:Analytical Biochemistry
出版年:2016
5.
Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine
作者:
John A. Duley
a
;
jduley@pharmacy.uq.edu.au" class="auth_mail" title="E-mail the corresponding author
;
Michael G. Henman
b
;
michael.henman@mater.org.au" class="auth_mail" title="E-mail the corresponding author
;
Kevin H. Carpenter
c
;
kevin.carpenter@health.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author
;
Michael J. Bamshad
d
;
mbamshad@u.washington.edu" class="auth_mail" title="E-mail the corresponding author
;
George A. Marshall
e
;
george.marshall@mater.org.au" class="auth_mail" title="E-mail the corresponding author
;
Chee Y. Ooi
f
;
i
;
keith.ooi@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author
;
Bridget Wilcken
g
;
bridget.wilcken@health.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author
;
Jason R. Pinner
h
;
jason.pinner@sswahs.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author
关键词:
AST
;
aspartate transaminase
;
ALT
;
alanine transaminase
;
CYP
;
cytochrome-P450
;
Cyt C
;
cytochrome C
;
DHO
;
dihydroorotic acid
;
DHODH
;
DHO dehydrogenase
;
EDTA
;
ethylenediamine-tetraacetic acid
;
FMN
;
flavin mononucleotide
;
GGT
;
gamma-glutamyl transferase
;
LC-MS/MS
;
high performance liquid chromatography-tandem mass spectrometry
;
OA
;
orotic acid
;
POADS
;
post-axial acrofacial dysostosis
;
UMP
;
uridine monophosphate
;
UQH2
;
reduced ubiquinone
刊名:Molecular Genetics and Metabolism
出版年:2016
6.
Respiratory supercomplexes and the functional segmentation of the CoQ pool
作者:
Raquel Moreno-Loshuertos
b
;
José
;
Antonio Enrí
;
quez
a
;
b
;
jaenriquez@cnic.es" class="auth_mail" title="E-mail the corresponding author
关键词:
BN-PAGE
;
blue native polyacrylamide gel electrophoresis
;
CI to CV
;
complex I to complex V
;
CoQ
;
coenzyme Q
;
cyt c
;
cytochrome c
;
DHODH
;
dihydroorotate dehydrogenase
;
G3PDH
;
glycerol-3-phosphate dehydrogenase
;
IMM
;
inner mitochondrial membrane
;
LOM
;
loss of memory
;
mETC
;
mitochondrial electron transport chain
;
OXPHOS
;
oxidative phosphorylation
;
PE
;
phosphatidylethanolamine
;
ROS
;
reactive oxygen species
;
SC
;
supercomplex
;
SCAF1
;
supercomplex assembly factor 1
;
SDH
;
succinate dehydrogenase
;
TEM
;
tr
刊名:Free Radical Biology and Medicine
出版年:2016
7.
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
作者:
David B. Sykes
1
;
2
;
11
;
12
;
15
;
dbsykes@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
;
Youmna S. Kfoury
1
;
11
;
12
;
Franç
;
ois E. Mercier
1
;
11
;
12
;
Mathias J. Wawer
3
;
Jason M. Law
4
;
13
;
Mark K. Haynes
5
;
Timothy A. Lewis
4
;
Amir Schajnovitz
1
;
11
;
12
;
Esha Jain
1
;
Dongjun Lee
1
;
11
;
12
;
Hanna Meyer
6
;
Kerry A. Pierce
7
;
Nicola J. Tolliday
3
;
Anna Waller
5
;
Steven J. Ferrara
3
;
Ashley L. Eheim
6
;
Detlef Stoeckigt
6
;
Katrina L. Maxcy
1
;
Julien M. Cobert
1
;
Jacqueline Bachand
1
;
Brian A. Szekely
1
;
Siddhartha Mukherjee
8
;
Larry A. Sklar
5
;
Joanne D. Kotz
4
;
Clary B. Clish
7
;
Ruslan I. Sadreyev
9
;
10
;
Paul A. Clemons
4
;
Andreas Janzer
6
;
Stuart L. Schreiber
4
;
13
;
14
;
David T. Scadden
1
;
2
;
11
;
12
;
dscadden@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
acute myeloid leukemia
;
differentiation
;
HoxA9
;
high-throughput screen
;
phenotypic screen
;
leukemia-initiating cell
;
dihydroorotate dehydrogenase
;
brequinar
;
metabolic inhibitor
刊名:Cell
出版年:2016
8.
Exploring membrane respiratory chains
作者:
Bruno C. Marreiros
;
Filipa Calisto
;
Paulo J. Castro
;
Afonso M. Duarte
;
Filipa V. Sena
;
Andreia F. Silva
;
Filipe M. Sousa
;
Miguel Teixeira
;
Patrí
;
cia N. Refojo
;
Manuela M. Pereira
;
mpereira@itqb.unl.pt" class="auth_mail" title="E-mail the corresponding author
关键词:
ACIII
;
Alternative Complex III
;
ADH
;
Alcohol dehydrogenase
;
ALDH
;
Aldehyde dehydrogenase
;
AMO
;
Ammonia monooxygenase
;
AOX
;
Alternative oxidase
;
CISM
;
Complex Iron-Sulfur Molybdoenzyme
;
DAADH
;
d-amino acid dehydrogenase
;
DHODH
;
dihydroorotate dehydrogenase
;
DmsABC
;
DMSO reductase
;
DMSO
;
dimethyl sulfoxide
;
Dsr
;
dissimilatory sulfite reductase
;
ETF-QO
;
electron transfer flavoprotein
;
quinone oxidoreductase
;
Fdn-N
;
Formate dehydrogenase-N
;
GADH
;
d-glyceraldehyde dehydrogenase
;
GLDH
;
Glycerol dehydro
刊名:Biochimica et Biophysica Acta (BBA) - Bioenergetics
出版年:2016
9.
Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors
作者:
Clé
;
ment Grandin
a
;
b
;
c
;
1
;
Marianne-Lucas Hourani
b
;
c
;
1
;
Yves L. Janin
d
;
e
;
Daniel Dauzonne
f
;
g
;
h
;
Hé
;
lè
;
ne Munier-Lehmann
d
;
e
;
Adeline Paturet
a
;
Fabrice Taborik
a
;
Astrid Vabret
i
;
Hugues Contamin
a
;
hugues.contamin@cynbiose.com" class="auth_mail" title="E-mail the corresponding author
;
Fré
;
dé
;
ric Tangy
b
;
c
;
frederic.tangy@pasteur.fr" class="auth_mail" title="E-mail the corresponding author
;
Pierre-Olivier Vidalain
b
;
c
;
pierre-olivier.vidalain@parisdescartes.fr" class="auth_mail" title="E-mail the corresponding author
关键词:
Cynomolgus macaques
;
Respiratory syncytial virus
;
Pyrimidine biosynthesis inhibitors
;
Antiviral compounds
;
Dihydroorotate dehydrogenase
刊名:Antiviral Research
出版年:2016
10.
Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum
作者:
Gowtham Subramanian
a
;
&dagger
;
;
C.P. Babu Rajeev
b
;
&dagger
;
;
Chakrabhavi Dhananjaya Mohan
c
;
Ameya Sinha
a
;
Trang T.T. Chu
a
;
Sebastian Anusha
b
;
Huang Ximei
d
;
Julian E. Fuchs
e
;
f
;
Andreas Bender
e
;
Kanchugarakoppal S. Rangappa
c
;
Rajesh Chandramohanadas
a
;
rajesh@sutd.edu.sg" class="auth_mail" title="E-mail the corresponding author
;
Basappa
b
;
salundibasappa@gmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Hydralazines
;
Antimalarials
;
Dihydroorotate dehydrogenase
;
P. falciparum
;
Bronsted acidic ionic liquids
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
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