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在“Elsevier电子期刊”中，命中：5条，耗时：小于0.01 秒

在所有数据库中总计命中：5条

1.Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy

作者：Sze-Wan Li ; ^{swli@uhnresearch.ca" class="auth_mail" title="E-mail the corresponding author} ; Yong Liu ; Peter B. Sampson ; Narendra Kumar Patel ; Bryan T. Forrest ; Louise Edwards ; Radoslaw Laufer ; Miklos Feher ; Fuqiang Ban ; Donald E. Awrey ; Richard Hodgson ; Irina Beletskaya ; Guodong Mao ; Jacqueline M. Mason ; Xin Wei ; Xunyi Luo ; Reza Kiarash ; Erin Green ; Tak W. Mak ; Guohua Pan ; Henry W. Pauls ; ^{henry.pauls@cogeco.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：Polo-like kinase 4 ; PLK4 inhibitors ; Spiro[cyclopropane-1 ; 3&prime ; -indolin]-2&prime ; -ones ; (1H-Indazol-6-yl)-methylene)indolin-2-ones ; Antitumor agent

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK

作者：Radoslaw Laufer ; ^{Radek.Laufer@oicr.on.ca" class="auth_mail" title="E-mail the corresponding author} ; Sze-Wan Li ; Yong Liu ; Grace Ng ; Yunhui Lang ; Miklos Feher ; Richard Brokx ; Irina Beletskaya ; Richard Hodgson ; Guodong Mao ; Olga Plotnikova ; Donald E. Awrey ; Jacqueline M. Mason ; Xin Wei ; Dan Chi-Chia Lin ; Yi Che ; Reza Kiarash ; Brian Madeira ; Graham C. Fletcher ; Tak W. Mak ; Mark R. Bray ; Henry W. Pauls

关键词：Ar ; aryl ; ATP ; Adenosine-5&prime ; -triphosphate ; AUC ; area under the curve ; BA ; bioavailability ; CYP ; Cytochrome P450 ; DBU ; 1 ; 8-diazabicyclo[5.4.0]undec-7-ene ; DCM ; dichloromethane ; DIPEA ; diisopropylethylamine ; Δ ; heat ; DME ; 1 ; 2-dimethoxyethane ; DMF ; N ; N-dimethylformamide ; DMSO ; dimethyl sulfoxide ; dppf ; 1 ; 1&prime ; -bis(diphenylphosphino)ferrocene ; h ; hour or human (in MS) ; GI50 ; half maximal cell growth inhibitory concentration ; Hb ; hydrophobe ; IC50 ; half maximal inhibitory concentration ; m ; mou

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Hyperphosphorylation of Glucosyl C6 Carbons and Altered Structure of Glycogen in the Neurodegenerative Epilepsy Lafora Disease

作者：Felix Nitschke¹ ; ⁸ ; Peixiang Wang³ ; ⁸ ; Peter Schmieder⁵ ; Jean-Marie Girard³ ; Donald E. Awrey⁶ ; Tony Wang³ ; Johan Israelian³ ; XiaoChu Zhao³ ; Julie Turnbull³ ; Matthias Heydenreich² ; Erich Kleinpeter² ; Martin Steup¹ ; Berge A. Minassian³ ; ⁴ ; ⁷ ; ^{berge.minassian@sickkids.ca}

刊名：Cell Metabolism

出版年：2013

4.Spiro-naphthyridinone piperidines as inhibitors of S. aureus

作者：Peter B. Sampson ; Christine Picard ; Sean H ; erson ; Teresa E. McGrath ; Megan Domagala ; Andrew Leeson ; Vladimir Romanov ; Donald E. Awrey ; Dhushy Thambipillai ; Elias Bardouniotis ; Nachum Kaplan ; Judd M. B

关键词：Enoyl-ACP reductase ; Naphthyridinone

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2009

5.2,3,4,5-Tetrahydro-1H-pyrido[2,3-b

作者：Jailall Ramnauth ; Mathew D. Surman ; Peter B. Sampson ; Bryan Forrest ; Jeff Wilson ; Emily Freeman ; David D. Manning ; Fern ; o Martin ; Andras Toro ; Megan Domagala ; Donald E. Awrey ; Elias Bardouniotis ; Nach

关键词：FabI inhibitors ; 234 ; 5-Tetrahydro-1H-pyrido ; [2 ; 3-e][1 ; 4]diazepine ; Antibacterial ; Enoyl ACP reductase ; MRSA ; Thigh infection model

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2009

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