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内部出版物
CNKI学位论文(40)
知网期刊论文(5)
在“
Elsevier电子期刊
”中,
命中:
6
条,耗时:小于0.01 秒
在所有数据库中总计命中:
45
条
1.
Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibito
r
s
作者:
Haixia Wang
;
J. David Lawson
;
Nick Sco
r
ah
;
R
uhi Kam
r
an
;
Ma
r
k S. Hixon
;
Joy Atienza
;
Douglas
R
.
Dougan
;
Ma
r
k Sabat
关键词:
Alk5
;
Inhibito
r
s
;
Activin
;
Kinase
;
T
r
ansfo
r
ming
;
G
r
owth
;
Facto
r
;
SBDD
刊名:Bioo
r
ganic & Medicinal Chemist
r
y Lette
r
s
出版年:2016
2.
Design, synthesis, and biological activities of novel hexahyd
r
opy
r
azino[1,2-a]indole de
r
ivatives as potent inhibito
r
s of apoptosis (IAP) p
r
oteins antagonists with imp
r
oved memb
r
ane pe
r
meability ac
r
oss MDR1 exp
r
essing cells
作者:
Zenyu Shiokawa
;
Kenta
r
o Hashimoto
;
Bunnai Saito
;
Yuya Ogu
r
o
;
Hi
r
oyuki Sumi
;
Masato Yabuki
;
Mie Yoshimatsu
;
Yohei Kosugi
;
Yasuyuki Debo
r
i
;
Nao Mo
r
ishita
;
Douglas
R
.
Dougan
;
Gyo
r
gy P. Snell
;
Sei Yoshida
;
Tomoyasu Ishikawa
关键词:
HATU
;
O-(7-azabenzot
r
iazol-1-yl)-N
N ;
N&p
r
ime
;
N&p
r
ime
;
-tet
r
amethylu
r
onium hexafluo
r
ophosphate
;
DIPEA
;
N-ethyldiisop
r
opylamine
;
Ac
;
acetyl
;
CDCl3
;
deute
r
atedchlo
r
ofo
r
m
;
DMF
;
N
;
N-dimethylfo
r
mamide
;
DMSO
;
dimethyl sulfoxide
;
DMT-MM
;
4-(4
;
6-dimethoxy-1
3 ;
5-t
r
iazin-2-yl)-4-methylmo
r
pholinium chlo
r
ide
;
EDC
;
1-ethyl-3-(3-dimethylaminop
r
opyl)ca
r
bodiimide
;
Et
;
ethyl
;
HOBT
;
1-hyd
r
oxybenzot
r
iazole
;
i
;
iso
;
mp
;
melting point
;
Me
;
methyl
;
Pd/C
;
palladium on ca
r
bon
;
Pd(OH)2/C
;
palladium hyd
r
oxide on ca
r
bon
;
P
刊名:Bioo
r
ganic and Medicinal Chemist
r
y
出版年:15 Decembe
r
, 2013
3.
Design, ste
r
eoselective synthesis, and biological evaluation of novel t
r
i-cyclic compounds as inhibito
r
of apoptosis p
r
oteins (IAP) antagonists
作者:
Mo
r
ite
r
u Asano
;
Kenta
r
o Hashimoto
;
Bunnai Saito
;
Zenyu Shiokawa
;
Hi
r
oyuki Sumi
;
Masato Yabuki
;
Mie Yoshimatsu
;
Kazunobu Aoyama
;
Te
r
uki Hamada
;
Nao Mo
r
ishita
;
Douglas
R
.
Dougan
;
Cliffo
r
d D. Mol
;
Sei Yoshida
;
Tomoyasu Ishikawa
关键词:
Inhibito
r
of apoptosis p
r
oteins (IAP)
;
Octahyd
r
o-1H-cyclop
r
opa[4
;
5]py
rr
olo[1
;
2-a]py
r
azine
;
Simmons&minus
;
Smith cyclop
r
opanation
刊名:Bioo
r
ganic and Medicinal Chemist
r
y
出版年:2013
4.
Discove
r
y of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-
r
ibose)polyme
r
ase inhibito
r
s
作者:
Anthony
R
. Gangloff
;
Jason B
r
own
;
R
on de Jong
;
Douglas
R
.
Dougan
;
Cha
r
les E. G
r
imshaw
;
Ma
r
k Hixon
;
Andy Jennings
;
R
uhi Kam
r
an
;
And
r
e Ki
r
yanov
;
Shawn O¡¯Connell
;
Ewan Taylo
r
;
Phong Vu
关键词:
Poly(ADP-
r
ibose)polyme
r
ase inhibito
r
s
;
PA
R
P-1
;
St
r
uctu
r
e-based d
r
ug design
;
1
;
4-Benzoxazin-3-one
;
Chemopotentiation
刊名:Bioo
r
ganic and Medicinal Chemist
r
y Lette
r
s
出版年:2013
5.
St
r
uctu
r
e-based design and synthesis of py
rr
ole de
r
ivatives as MEK inhibito
r
s
作者:
Michael B. Wallace
;
Ma
r
k E. Adams
;
Toufike Kanouni
;
Cliffo
r
d D. Mol
;
Douglas
R
.
Dougan
;
Victo
r
ia A. Fehe
r
;
Shawn M. O’
;
Connell
;
Lihong Shi
;
Pet
r
o Halkowycz
;
Qing Dong
关键词:
MEK
;
Py
rr
ole
;
Oncology
刊名:Bioo
r
ganic and Medicinal Chemist
r
y Lette
r
s
出版年:2010
6.
Design, synthesis and st
r
uctu
r
e–activity
r
elationships of 1,3,4-oxadiazole de
r
ivatives as novel inhibito
r
s of glycogen synthase kinase-3β
作者:
Mo
r
ihisa Saitoh
;
Jun Kunitomo
;
Eiji Kimu
r
a
;
Yoji Hayase
;
Hi
r
omi Kobayashi
;
No
r
iko Uchiyama
;
Tomohi
r
o Kawamoto
;
Toshimasa Tanaka
;
Cliffo
r
d D. Mol
;
Douglas
R
.
Dougan
;
Ga
rr
et S. Texto
r
;
Gyo
r
gy P. Snell
关键词:
GSK-3β
;
Alzheime
r
’
;
s disease
;
Oxadiazole
;
D
r
ug design
刊名:Bioo
r
ganic and Medicinal Chemist
r
y
出版年:2009
1
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