搜索页_+ECVAM

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

常用资源

在“Elsevier电子期刊”中，命中：216条，耗时：小于0.01 秒

1.Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase I)

作者：K.R. Mewes^a ; ^{karsten.mewes@henkel.com" class="auth_mail" title="E-mail the corresponding author} ; A. Fischer^a ; N.N. Zö ; ller^b ; V. Laubach^b ; A. Bernd^b ; A. Jacobs^c ; A. van Rompay^c ; M. Liebsch^d ; R. Pirow^d ; D. Petersohn^a

关键词：1-BH ; 1-bromohexane ; ALI ; Air-Liquid Interface ; BLR ; Between-laboratory-reproducibility ; CyA ; Cyclamen aldehyde ; D-PBS ; Dulbecco's phosphate-buffered saline ; ECETOC ; European Centre for Ecotoxicology and Toxicology ; EURL-ECVAM ; European Union Reference Laboratory for the Validation of Alternative Methods ; ET50 ; effective time at 50% viability ; EU ; European Union ; GC/MS ; gas chromatography/mass spectroscopy ; MTT ; 3-(4 ; 5-dimethylthiazo-2-yl)-2 ; 5-diphenyltetrazoliumbromide ; NC ; negative control ; OD

刊名：Toxicology in Vitro

出版年：2016

2.Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates

作者：Hirohisa Nagahori^a ; ^{nagahori@sc.sumitomo-chem.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Noriyuki Suzuki^a ; Florian Le Coz^a ; Takashi Omori^b ; Koichi Saito^a

关键词：EST ; embryonic stem cell test ; ECVAM ; European Center for the Validation of Alternative Methods ; PBPK ; physiologically based pharmacokinetics ; MIC ; metabolically inapplicable candidate ; PBS ; phosphate buffered saline ; DMSO ; dimethyl sulfoxide ; MD ; maximum dose ; ESI ; electrospray ionization ; Rt ; retention time ; Fh ; hepatic availability ; ROC ; receiver operating characteristic curve ; PM ; prediction model ; IC50 ; the concentration that reduces the viability of cells to 50% ; ID50 ; the concentration th

刊名：Toxicology Letters

出版年：2016

3.Assessment of cosmetic ingredients in the in vitro reconstructed human epidermis test method EpiSkinℿusing HPLC/UPLC-spectrophotometry in the MTT-reduction assay

作者：N. Alé ; pé ; e^a ; ^{nalepee@rd.loreal.com" class="auth_mail" title="E-mail the corresponding author} ; J. Hibatallah^b ; M. Klaric^c ; K.R. Mewes^d ; U. Pfannenbecker^e ; P. McNamee^f

关键词：CAS RN ; Chemical Abstract Service Registry Number ; R2 ; coefficient of determination ; Cat. 1 ; Category 1 ; Cat. 2 ; Category 2 ; EIT ; eye irritation test ; DG SANCO ; European Commission Directorate General for Health and Consumer Protection ; EURL ECVAM ; European Union Reference Laboratory for Alternatives to Animal Testing ; FDA ; Food and Drug Administration ; HPLC-UPLC-spectrophotometry ; high/ultra high performance liquid chromatography-spectrophotometry ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyl

刊名：Toxicology in Vitro

出版年：2016

4.A retrospective evaluation method for in vitro mammalian genotoxicity tests using cytotoxicity index transformation formulae

作者：Yurika Fujita ; Toshio Kasamatsu ; Naohiro Ikeda ; Naohiro Nishiyama ; Hiroshi Honda ; ^{honda.hiroshi@kao.co.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：CA ; chromosomal aberration ; DB ; database ; ECVAM ; The European Centre for the Validation of Alternative Methods ; IWGT ; International Workshops on Genotoxicity Testing ; JEC ; Japan Existing Chemical ; LOGEL ; lowest observed genotoxicity effect level ; MN ; micronucleus ; OECD ; Organization for Economic Co-operation and Development ; RCC ; relative cell count ; RICC ; relative increase in cell count ; RPD ; relative population doubling ; PD ; population doubling ; TG ; test guideline

刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis

出版年：2016

5.Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase II)

关键词：EURL-ECVAM ; European Union Reference Laboratory for Alternatives to Animal Testing ; FHG ; Fraunhofer Gesellschaft ; FUB ; Institute of Pharmacy at the Freie Universitä ; t Berlin ; UN GHS ; United Nations Globally Harmonized System of Classification and Labelling of Chemicals ; hEK ; Human epidermal keratinocytes ; HEN ; Henkel AG &Co. KGaA ; MTT ; 3-(4 ; 5-Dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazoliumbromid ; OECD ; Organization for Economic Co-operation and Development ; OS-REp ; Open source reconstructed ep

刊名：Toxicology in Vitro

出版年：2016

6.Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

作者：David Kirkland^a ; Peter Kasper^b ; Hans-Jö ; rg Martus^c ; Lutz Mü ; ller^d ; Jan van Benthem^e ; Federica Madia^f ; Raffaella Corvi^f ; ^{raffaella.corvi@ec.europa.eu" class="auth_mail" title="E-mail the corresponding author}

关键词：CA ; chromosomal aberrations ; MLA ; mouse lymphoma tk+/&minus ; mutation assay ; MN ; micronuclei ; UDS ; unscheduled DNA synthesis ; IARC ; International Agency for Research on Cancer ; NTP ; National Toxicology Program ; RTG ; relative total growth ; E ; equivocal ; ip ; intraperitoneal ; HPRT ; hypoxanthine-guanine phosphoribosyl transferase ; &minus ; ve ; negative ; +ve ; positive ; MoA ; mode of action

刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis

出版年：2016

7.Validation of a human cell based high-throughput genotoxicity assay 鈥楢nthem鈥檚 Genotoxicity screen鈥?using ECVAM recommended lists of genotoxic and non-genotoxic chemicals

作者：Lakshmi Rajakrishna ; Salini Krishnan Unni ; Madhuri Subbiah ; Sathish Sadagopan ; Ayyappan R. Nair ; Ravindra Ch ; rappa ; Ganesh Sambasivam ; Sunil Kumar Sukumaran

关键词：In vitro genotoxicity screen ; Human cell based ; High-throughput ; p21 ; GADD153 ; p53 ; Reporter based screen ; ECVAM

刊名：Toxicology in Vitro

出版年：February, 2014

8.Toxicity evaluation of nanocarriers for the oral delivery of macromolecular drugs

作者：P. Ojer^b ; ¹ ; ^{pojeroje@alumni.unav.es" class="auth_mail" title="E-mail the corresponding author} ; T. Iglesias^a ; ¹ ; ^{tiglesias@alumni.unav.es" class="auth_mail" title="E-mail the corresponding author} ; A. Azqueta^a ; ^{amazqueta@unav.es" class="auth_mail" title="E-mail the corresponding author} ; J.M. Irache^b ; ^{jmirache@unav.es" class="auth_mail" title="E-mail the corresponding author} ; A. Ló ; pez de Cerain^a ; ^{acerain@unav.es" class="auth_mail" title="E-mail the corresponding author}

关键词：ADME/PK ; absorption ; distribution ; metabolism ; excretion ; and pharmacokinetics ; ATP ; adenosine triphosphate ; B ; biocompatibility ; BCS ; Biopharmaceutics Classification System ; CS ; chitosan ; CTX ; ceftriaxone sodium ; DCFA ; 2&prime ; 7&prime ; -dichlorofluorescein diacetate ; EURL-ECVAM ; European Union Reference Laboratory for Alternatives to Animal Testing ; FAE ; follicle associated epithelia ; FDA ; Food and Drug Administration ; GALT ; gut associated lymphoid tissue ; GIT ; gastrointestinal tract ; GRAS ; Gene

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2015

9.A high throughput passive dosing format for the Fish Embryo Acute Toxicity test

作者：Lucia Vergauwen^a ; ^{lucia.vergauwen@uantwerpen.be" class="auth_mail" title="E-mail the corresponding author} ; Stine N. Schmidt^b ; Evelyn Stinckens^a ; Walid Maho^c ; Ronny Blust^d ; Philipp Mayer^b ; Adrian Covaci^c ; Dries Knapen^a

关键词：AhR ; aryl hydrocarbon receptor ; AOP ; adverse outcome pathway ; C ; (regular) control ; CBR(LIP)50 ; (lipid normalized) critical body residue ; Ea50 ; effective chemical activity ; EBR(LIP)50 ; (lipid normalized) effective body residue ; ED50 ; effective dose ; EI ; electron ionization mode ; EURL ECVAM ; European Union Reference Laboratory for alternatives to animal testing &ndash ; European Centre for the Validation of Alternative Methods ; FET ; Fish Embryo Acute Toxicity ; HOC ; hydrophobic organic compound ; Hp

刊名：Chemosphere

出版年：2015

10.Prospective multicentre study of the U-SENS test method for skin sensitization testing

作者：N. Alé ; pé ; e^a ; ^{nalepee@rd.loreal.com" class="auth_mail" title="E-mail the corresponding author} ; C. Piroird^a ; M. Aujoulat^b ; S. Dreyfuss^c ; S. Hoffmann^d ; A. Hohenstein^e ; M. Meloni^f ; L. Nardelli^a ; C. Gerbeix^g ; J. Cotovio^a

关键词：AOP ; Adverse Outcome Pathway ; BLR ; between-laboratory reproducibility ; CV ; cell viability ; DPRA ; Direct Peptide Reactivity Assay ; DMSO ; dimethyl sulfoxide ; EC ; effective concentration ; EURL-ECVAM ; European Union Reference Laboratory for alternatives to animal testing ; EU ; European Union ; GLP ; Good Laboratory Practice ; h-CLAT ; human Cell Line Activation Test ; IATA ; Integrated approaches to Testing and Assessment ; ITS ; Integrated Testing Strategies ; LLNA ; Local Lymph Node Assay ; OECD ; Organization

刊名：Toxicology in Vitro

出版年：2015

按检索点细分(216)

题名(30)

关键词(54)

文摘(172)

按出版年细分(216)

2027年及以后(12)

2016年(6)

2015年(6)

2013年(9)

2012年(17)

2011年(9)

2010年(16)

2009年(6)

2008年(8)

2007年(90)

2006年(4)

2005年(2)

2004年(2)

2003年(2)

2002年(3)

2001年(6)

2000年(2)

2000年及以前(16)