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在“Elsevier电子期刊”中，命中：150条，耗时：小于0.01 秒

在所有数据库中总计命中：356条

1.Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835

作者：Mikhail Krasavin^a ; ^{m.krasavin@spbu.ru} ; Alexey Lukin^b ; Daria Bagnyukova^b ; Nikolay Zhurilo^b ; Aleksei Golovanov^b ; Sergey Zozulya^c ; ^d ; Ihor Zahanich^c ; Daniel Moore^e ; Irina G. Tikhonova^e

关键词：Drug discovery ; FFA1 agonists ; Antidiabetic agents ; Spirocyclic motifs ; Hydrophobic interactions ; π&minus ; π stacking

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

作者：Zheng Li^a ; Miaobo Pan^a ; Xin Su^a ; Yuxuan Dai^a ; Mian Fu^a ; Xingguang Cai^a ; Wei Shi^a ; Wenlong Huang^a ; ^b ; ^{ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Hai Qian^a ; ^b ; ^{qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：FFA1 agonist ; GPR40 ; Ligand efficiency ; Type 2 diabetes ; Pyrrole

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

3.Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835

作者：Mikhail Krasavin^a ; ^{m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author} ; Alexey Lukin^b ; Daria Bagnyukova^b ; Nikolay Zhurilo^b ; Ihor Zahanich^c ; Sergey Zozulya^c ; ^d ; Jouni Ihalainen^e ; Markus M. Forsberg^e ; Marko Lehtonen^e ; Jarkko Rautio^e ; Daniel Moore^f ; Irina G. Tikhonova^f

关键词：GPCR ; GPR40 ; Free fatty acid receptor 1 ; FFA1 agonists ; Type 2 diabetes mellitus ; Prins reaction ; Spirocyclic motifs ; Metabolic stability

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

4.Discovery of novel free fatty acid receptor 1 agonists bearing triazole core via click chemistry

作者：Zheng Li^a ; Jianyong Yang^a ; Xuekun Wang^a ; Huilan Li^a ; Chunxia Liu^a ; Nasi Wang^a ; Wenlong Huang^a ; ^b ; ^{ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Hai Qian^a ; ^b ; ^{qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：FFA1 agonist ; GPR40 ; Triazole core ; Click chemistry ; Type 2 diabetes

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold

作者：Mikhail Krasavin^a ; ^{m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author} ; Alexey Lukin^b ; Nikolay Zhurilo^b ; Alexey Kovalenko^b ; Ihor Zahanich^c ; Sergey Zozulya^c ; ^d ; Daniel Moore^e ; Irina G. Tikhonova^e

关键词：GPR40 ; Free fatty acid receptor 1 ; FFA1 agonists ; Bioisosteric replacement ; Total polar surface area ; c ; Log P ; Metabolic stability ; Aqueous solubility

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors

作者：Carla Sosa-Alvarado^a ; Aurelio Herná ; ndez-Mé ; ndez^a ; M. Teresa Romero-Á ; vila^a ; Omar B. Sá ; nchez-Reyes^a ; Yoshinori Takei^b ; Gozoh Tsujimoto^b ; Akira Hirasawa^b ; J. Adolfo Garcí ; a-Sá ; inz^a ; ^{agarcia@ifc.unam.mx" class="auth_mail" title="E-mail the corresponding author}

关键词：FFAs ; free fatty acids ; DHA ; docosahexaenoic acid ; α-LA ; α-linolenic acid ; LPA ; lysophosphatidic acid ; PMA ; phorbol 12-myristate ; 13-acetate ; PKC ; protein kinase C ; ERK 1/2 ; extracellular-signal-regulated kinases 1/2 ; GFP ; green fluorescent protein ; GPCRs ; G protein-coupled receptors ; GRKs ; GPCR kinases

刊名：European Journal of Pharmacology

出版年：2015

7.Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

作者：Zheng Li^a ; Qianqian Qiu^a ; Xue Xu^b ; Xuekun Wang^a ; Lei Jiao^a ; Xin Su^a ; Miaobo Pan^a ; Wenlong Huang^a ; ^c ; ^{ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Hai Qian^a ; ^c ; ^{qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：FFA1 agonist ; GPR40 ; Liver toxicity ; Type 2 diabetes ; Heteroaromatics ; Dihedral angle

刊名：European Journal of Medicinal Chemistry

出版年：2016

8.GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space

作者：Cheng Chen^a ; ^b ; He Li^a ; Ya-Qiu Long^a ; ^{yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：GPR40 ; G protein-coupled receptor 40 ; FFA1 ; free fatty acid receptor 1 ; PK ; pharmacokinetic ; GSIS ; glucose-stimulated insulin secretion ; T2DM ; type 2 diabetes mellitus ; IDF ; International Diabetes Federation ; GLP-1 ; glucagon-like peptide1 ; GIP ; gastric inhibitory polypeptide ; DPP4 ; dipeptidyl peptidase-4 ; LA ; linoleic acid ; DHA ; docosahexaenoic acid ; IP3 ; inositol-triphosphate 3 ; DAG ; diacylglycerol ; PA ; palmitic acid ; OA ; oleic acid ; MOE ; molecular operating environment ; CNS ; central nervous sy

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.MCMC² (version 1.1.2): A Monte Carlo code for multiply charged clusters

作者：David A. Bonhommeau ^{david.bonhommeau@univ-reims.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Monte Carlo simulations ; Coarse-grained models ; Charged clusters and droplets ; Electrospray ionization

刊名：Computer Physics Communications

出版年：2016

10.On the number of N-free elements with prescribed trace

作者：Aleksandr Tuxanidy ^{AleksandrTuxanidyTor@cmail.carleton.ca" class="auth_mail" title="E-mail the corresponding author} ; Qiang Wang ; ^{wang@math.carleton.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：11T06 ; 11T24

刊名：Journal of Number Theory

出版年：2016

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