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在“Elsevier电子期刊”中，命中：336条，耗时：小于0.01 秒

1.New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation

作者：Iuliana-Monica Moise^a ; Alina Ghinet^a ; ^b ; ^c ; Dalila Belei^a ; Joë ; lle Dubois^d ; Amaury Farce^c ; ^e ; Elena Bî ; cu^a ; ^{elena@uaic.ro" class="auth_mail" title="E-mail the corresponding author}

关键词：Farnesyltransferase inhibitor ; Phenothiazine ; Chalcone ; Indolizine ; Antitumor agent

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors

作者：Melissa M. Cadelis^a ; Marie-Lise Bourguet-Kondracki^b ; Joë ; lle Dubois^c ; Alexis Valentin^d ; David Barker^a ; Brent R. Copp^a ; ^{b.copp@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author}

关键词：VYNGZASNGVAOMT-UHFFFAOYSA-N ; FVTJXDIACKJEPH-UHFFFAOYSA-N ; HYLGGIUWJAJQJB-UHFFFAOYSA-N ; DWAGHTAECLYWCT-WNAAXNPUSA-N ; QONRUBHKACJNHR-UHFFFAOYSA-N ; AMIIUBKFJIKNDJ-UHFFFAOYSA-N ; XCQUMLRJBMLRSM-ZXNSPXPDSA-N ; RDQOOZOSOQUKJT-JTOYJDTJSA-N ; IKBLDYRKOHGRGM-YBFXNURJSA-N ; GNKHZLCLDITUKE-UHFFFAOYSA-N ; YRLLMZGITSQOAZ-UHFFFAOYSA-N ; NQVBCGTZRWHVSY-UHFFFAOYSA-N ; CFNTYPNQFGENAH-LFVJCYFKSA-N ; SZRIUQOLPCIHRA-GKTLAHRSSA-N ; YGNPHNOMVBPITA-VCHYOVAHSA-N

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

3.Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase

作者：Benjamin C. Jennings^a ; Amy M. Danowitz^b ; Yen-Chih Wang^c ; Richard A. Gibbs^d ; ^&dagger ; ; Mark D. Distefano^c ; ^e ; Carol A. Fierke^a ; ^f ; ^{fierke@umich.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Protein farnesylation ; Protein prenylation ; Click chemistry ; Substrate analogs ; Post-translational modification

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds

作者：Gina-Mirabela Dumitriu^a ; Elena Bî ; cu^a ; Dalila Belei^a ; Benoî ; t Rigo^b ; ^c ; Joë ; lle Dubois^d ; Amaury Farce^b ; ^e ; Alina Ghinet^a ; ^b ; ^c ; ^{alina.ghinet@hei.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Farnesyltransferase ; Phenothiazine ; Cysteine ; Methionine ; Serine ; Valine ; CAAX inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

5.Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors

作者：Damien Bosc^a ; Elisabeth Mouray^b ; Sandrine Cojean^c ; Caio Haddad Franco^d ; Philippe M. Loiseau^c ; Lucio H. Freitas-Junior^d ; Carolina Borsoi Moraes^d ; Philippe Grellier^b ; Joë ; lle Dubois^a ; ^{joelle.dubois@cnrs.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Arylthiophene ; Protozoan parasites ; Trypanosoma ; Leishmania ; Malaria

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs

作者：Shun Ying Quah^a ; ¹ ; Michelle Siying Tan^a ; ¹ ; Yuan Han Teh^a ; ¹ ; Johnson Stanslas^a ; ^b ; ^{rcxjs@upm.edu.my" class="auth_mail" title="E-mail the corresponding author} ; ^{jstanslas@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AGP ; Andrographolide ; APT1 ; Acyl protein thioesterase 1 ; COX-2 ; cyclooxygenase-2 ; DPI ; Dual prenylation inhibitor ; ERK ; Extracellular signal-regulated kinase ; FBDD ; Fragment-based drug discovery ; FTase ; Farnesyltransferase ; FTIs ; Farnesyltransferase inhibitors ; G12 ; Glycine-12 ; G13 ; Glycine-13 ; Q61 ; Glutamine-61 ; GAP ; GTPase-activating protein ; GDP ; Guanosine diphosphate ; GEF ; Guanine nucleotide exchange factor ; GGTase I ; Geranylgeranyltransferase I ; GGTI ; Geranylgeranyltransferase inhibitor ; GT

刊名：Pharmacology and Therapeutics

出版年：2016

7.Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer

作者：Ellie Rad ; Andrew R. Tee ; ^{teea@cardiff.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：CAPRI ; Ca2+-promoted RAS inactivator ; CRMP-2 ; collapsin response mediator protein-2 ; CSRD ; cysteine/serine-rich domain ; CTD ; C-terminal domain ; ERK ; extracellular signal-regulated kinase ; FTI ; farnesyltransferase inhibitor ; FAK1 ; focal adhesion kinase 1 ; GAP ; GTPase activating protein ; GRD ; GAP related domain ; GEF ; guanine nucleotide exchange factor ; HIF ; hypoxia inducible factor ; LIMK ; LIM domain kinase ; LOH ; loss of heterozygosity ; MAPK ; mitogen-activated protein kinase ; MEK ; mitogen-activated

刊名：Seminars in Cell & Developmental Biology

出版年：2016

8.Pleiotropic effects of antitumour alkylphospholipids on cholesterol transport and metabolism

作者：Pablo Rí ; os-Marco ; Carmen Marco ; Francisco J. Cueto ; Marí ; a P. Carrasco ; ¹ ; ² ; ^{mpazcj@ugr.es" class="auth_mail" title="E-mail the corresponding author} ; José ; M. Jimé ; nez-Ló ; pez ; ¹ ; ² ; ^{jmajimen@ugr.es" class="auth_mail" title="E-mail the corresponding author}

关键词：ABCA1 ; ATP-binding cassette transporter isoform A1 ; APL ; alkylphospholipid ; apoA1 ; apolipoprotein A1 ; CETP ; cholesteryl ester transfer protein ; CYP7A1 ; cholesterol 7α-hydroxylase ; CYP27 ; sterol 27-hydroxylase ; DHCR7 ; 7-dehydrocholesterol reductase ; ER ; endoplasmic reticulum ; FBS ; fetal bovine serum ; FDFT1 ; farnesyl-diphosphate farnesyltransferase 1 ; FDPS ; farnesyl diphosphate synthase ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HDL ; high-density lipoprotein ; HMG ; 3-hydroxy-3-methylglutaryl

刊名：Experimental Cell Research

出版年：2016

9.8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells

作者：Idrees Mohammed^a ; ^&dagger ; ; Shahienaz E. Hampton^a ; ^&dagger ; ; Louise Ashall^a ; ^&dagger ; ; Emily R. Hildebrandt^c ; ^&dagger ; ; Robert A. Kutlik^b ; Surya P. Manandhar^c ; Brandon J. Floyd^b ; Haley E. Smith^a ; Jonathan K. Dozier^d ; Mark D. Distefano^d ; Walter K. Schmidt^c ; Timothy M. Dore^a ; ^b ; ^{timothy.dore@nyu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Ras converting enzyme (Rce1) ; Protease inhibitors ; Ras mislocalization

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Mammalian farnesyltransferase α subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A) - dependent intracellular trafficking through recycling endosomes

作者：Marta H. Kubala ; Suzanne J. Norwood ; Guillermo A. Gomez ; Alun Jones ; Wayne Johnston ; Alpha S. Yap ; Sergey Mureev ; Kirill Alexandrov ; ^{k.alexandrov@uq.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：Farnesyltransferase ; Oligomerization ; Isoprenylation ; Trafficking

刊名：Biochemical and Biophysical Research Communications

出版年：2015

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