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CNKI期刊论文0611(5)
知网期刊论文(5291)
在“
Elsevier电子期刊
”中,
命中:
338
条,耗时:0.1149458 秒
在所有数据库中总计命中:
12,119
条
1.
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by
fragment
-
based
drug
design
作者:
Fatiha Benmansour
a
;
b
;
c
;
Iuni Trist
d
;
Bruno Coutard
a
;
b
;
Etienne Decroly
a
;
b
;
Gilles Querat
e
;
Andrea Brancale
d
;
Karine Barral
a
;
b
;
c
;
karine.barral@inserm.fr
关键词:
Phenyl [(phenylcarbamoyl)amino]benzene-1-sulfonate derivatives
;
N-Phenyl-[(phenylcarbamoyl)amino]benzene-1-sulfonamide derivatives
;
Fragment
-linking strategy
;
Dengue virus
;
NS5 methyltransferase inhibitors
;
Antiviral activity
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor
design
作者:
Michelle S. Miller
a
;
Sweta Maheshwari
b
;
Fiona M. McRobb
c
;
Kenneth W. Kinzler
d
;
L. Mario Amzel
b
;
Bert Vogelstein
d
;
Sandra B. Gabelli
a
;
b
;
e
;
gabelli@jhmi.edu
关键词:
PIK3CA
;
PI3K
;
PIP2
;
PIP3
;
Fragment
-
based
drug
discovery
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
3.
Fragment
library
design
, synthesis and expansion: nurturing a synthesis and training platform
作者:
Peter C. RayAuthor Vitae
;
Michael Kiczun
;
Margaret Huggett
;
Andrew Lim
;
Federica Prati
;
Ian H. Gilbert
;
i.h.gilbert@dundee.ac.uk
Author Vitae
;
Paul G. Wyatt
;
p.g.wyatt@dundee.ac.uk
Author Vitae
刊名:
Drug
Discovery Today
出版年:2017
4.
Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and
fragment
rearrangement
作者:
Xiao Li
a
;
Ping Gao
a
;
Boshi Huang
a
;
Zhongxia Zhou
a
;
Zhao Yu
a
;
Zheng Yuan
c
;
Huiqing Liu
c
;
Christophe Pannecouque
b
;
Dirk Daelemans
b
;
Erik De Clercq
b
;
Peng Zhan
a
;
zhanpeng1982@sdu.edu.cn
;
Xinyong Liu
a
;
xinyongl@sdu.edu.cn
关键词:
HIV
;
NNRTIs
;
Indolylarylsulfones
;
Antiviral activity
;
SAR
;
Molecular modeling
;
Chemical space
;
Drug
design
刊名:European Journal of Medicinal Chemistry
出版年:2017
5.
Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids:
Design
, synthesis and evaluation of anti-tubercular activity
作者:
Xiaoyun Lu
a
;
b
;
1
;
luxy2016@jnu.edu.cn
;
Jian Tang
b
;
c
;
1
;
Shengyang Cui
b
;
c
;
Baojie Wan
d
;
Scott G. Franzblauc
d
;
Tianyu Zhang
b
;
Xiantao Zhang
e
;
Ke Ding
a
;
b
关键词:
Anti-tubercular
;
Hybrid
;
Mtb
;
Pyrazolo[1
;
5-a]pyridine-3-carboxamide
刊名:European Journal of Medicinal Chemistry
出版年:2017
6.
Calcium phosphate nanoparticles functionalized with alendronate-conjugated polyethylene glycol (PEG) for the treatment of bone metastasis
作者:
Weijing Chu
a
;
b
;
1
;
Yanjuan Huang
a
;
1
;
Chanzhen Yang
a
;
Yunhui Liao
a
;
Xuefei Zhang
a
;
Mina Yan
a
;
Shengmiao Cui
c
;
cuishengmiao@qq.com
;
Chunshun Zhao
a
;
zhaocs@mail.sysu.edu.cn
关键词:
Bone targeting
;
Alendronate
;
Bone metastasis
;
Calcium phosphate nanoparticle
刊名:International Journal of Pharmaceutics
出版年:2017
7.
Discovery of potent, reversible MetAP2 inhibitors via
fragment
based
drug
discovery and structure
based
drug
design
—Part 2
作者:
Christopher McBride
a
;
;
Zacharia Cheruvallath
a
;
Mallareddy Komandla
a
;
Mingnam Tang
a
;
Pamela Farrell
b
;
J. David Lawson
c
;
Darin Vanderpool
b
;
Yiqin Wu
b
;
Douglas R. Dougan
d
;
Artur Plonowski
b
;
Corine Holub
b
;
Chris Larson
b
关键词:
Methionine aminopeptidase-2
;
MetAP2
;
Metalloprotease
;
Fragment
-
based
drug
discovery
;
FBDD
;
Structure-
based
drug
design
;
SBDD
;
Pyrazolo[4
;
3-b]indoles
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
8.
The ways and means of
fragment
-
based
drug
design
作者:
Bradley C. Doak
;
Raymond S. Norton
;
Martin J. Scanlon
;
martin.scanlon@monash.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Screening
;
Protein
;
Medicinal chemistry
;
Structure-
based
drug
design
刊名:Pharmacology and Therapeutics
出版年:2016
9.
Novel approach of
fragment
-
based
lead discovery applied to renin inhibitors
作者:
Michiko Tawada
a
;
michiko.tawada@takeda.com" class="auth_mail" title="E-mail the corresponding author
;
Shinkichi Suzuki
a
;
Yasuhiro Imaeda
a
;
Hideyuki Oki
a
;
Gyorgy Snell
b
;
Craig A. Behnke
b
;
&dagger
;
;
Mitsuyo Kondo
a
;
Naoki Tarui
a
;
Toshimasa Tanaka
a
;
Takanobu Kuroita
a
;
Masaki Tomimoto
a
关键词:
Fragment
-
based
drug
discovery (FBDD)
;
High-throughput synthetic chemistry
;
Structure-
based
drug
design
(SBDD)
;
Renin inhibitor
;
Crystal structure
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
10.
Fragment
-assisted hit investigation involving integrated HTS and
fragment
screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors
作者:
Jeffrey G. Varnes
a
;
jeffrey.varnes@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author
;
Stefan Geschwindner
b
;
Christopher R. Holmquist
a
;
Janet Forst
a
;
Xia Wang
a
;
Niek Dekker
b
;
Clay W. Scott
a
;
Gaochao Tian
a
;
Michael W. Wood
a
;
Jeffrey S. Albert
a
;
jeffrey.albert@intellisynrd.com" class="auth_mail" title="E-mail the corresponding author
关键词:
PDE10A
;
Fragment
-
based
drug
discovery
;
Fragment
-assisted
drug
discovery
;
Phosphodiesterase inhibitor
;
Schizophrenia
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
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