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内部出版物
在“
Elsevier电子期刊
”中,
命中:
151
条,耗时:小于0.01 秒
1.
A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR
L858R/T790M
mutant with improved pharmacokinetic properties
作者:
Lei Yu
a
;
b
;
Minhao Huang
a
;
b
;
Tianfeng Xu
a
;
b
;
Linjiang Tong
d
;
Xiao-e Yan
e
;
Zhang Zhang
a
;
Yong Xu
a
;
Caihong Yun
e
;
Hua Xie
d
;
hxie@simm.ac.cn
;
Ke Ding
a
;
c
;
ding_ke@gibh.ac.cn
;
Xiaoyun Lu
c
;
luxy2016@jnu.edu.cn
关键词:
EGFRT790M mutant
;
Pyrido[2
;
3-d]pyrimidin-7-ones
;
Pharmacokinetic property
;
NSCLC
;
Irreversible inhibitor
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
387 PDGFR/STAT3 Signaling Pathway Regulating the Phenotypic Transition of Corpus Cavernosum Smooth Muscle
作者:
Y. Junfeng
;
H. Wenjie
;
L. Bodong
刊名:The Journal of Sexual Medicine
出版年:2017
3.
5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications
作者:
Fan Yao
a
;
Ming Zhang
a
;
Li Chen
a
;
b
;
chen_lab@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
ACC
;
carboxylase
;
AdipoR
;
adiponectin receptors
;
ADP
;
adenosine diphosphate
;
AMP
;
adenosine monophosphate
;
AMPK
;
5&prime
;
-monophosphate-activated protein kinase
;
ATP
;
adenosine triphosphate
;
CaMKK
;
Ca2+ calmodulin-dependent protein kinase kinase
;
DEPTOR
;
DEP domain-containing mTOR-interacting protein
;
DM
;
Diabetes mellitus
;
DN
;
Diabetic nephropathy
;
ERK
;
extracellular signal-regulated kinase
;
FoxO
;
forkhead box class O
;
GFRs
;
glomerular filtration rates
;
IKK
;
IκB kinase
;
JLDG
;
Jinlida granule
;
J
刊名:Acta Pharmaceutica Sinica B
出版年:2016
4.
Synthesis and biological evaluation of azole-diphenylpyrimidine derivatives (AzDPPYs) as potent T790M mutant form of epidermal growth factor receptor inhibitors
作者:
Zhendong Song
a
;
&dagger
;
;
Yue Jin
a
;
&dagger
;
;
Yang Ge
a
;
Changyuan Wang
a
;
Jianbin Zhang
a
;
Zeyao Tang
a
;
Jinyong Peng
a
;
Kexin Liu
a
;
Yanxia Li
b
;
liyanxia001@163.com" class="auth_mail" title="E-mail the corresponding author
;
Xiaodong Ma
a
;
xiaodong.ma@139.com" class="auth_mail" title="E-mail the corresponding author
关键词:
NSCLC
;
EGFR T790M
;
Inhibitors
;
Synthesis
;
Azole-diphenylpyrimidine
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
5.
Discovery of new [1,4]dioxino[2,3-f]quinazoline-based inhibitors of EGFR including the T790M/L858R mutant
作者:
Xuemei Qin
a
;
Zhipeng Li
a
;
Leifu Yang
b
;
Peng Liu
c
;
Liming Hu
a
;
huliming@bjut.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Chengchu Zeng
a
;
Zhiyong Pan
b
关键词:
EGFR inhibitors
;
Lung cancer
;
T790M/L858R mutation
;
Quinazoline
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
6.
Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors
作者:
Qiang Xiao
a
;
Rong Qu
b
;
Dingding Gao
a
;
Qi Yan
a
;
Linjiang Tong
b
;
Wei Zhang
a
;
Jian Ding
b
;
Hua Xie
b
;
hxie@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
;
Yingxia Li
a
;
liyx417@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
YXBJKXUKIDUKIH-UHFFFAOYSA-N
;
BULITYBNVIHSDM-UHFFFAOYSA-N
;
YDWRFDRHSNTINI-UHFFFAOYSA-N
;
JGVSJOHBWPEWKW-UHFFFAOYSA-N
;
XJCBAYFIITUVDS-UHFFFAOYSA-N
;
WAZLQAVHYOQHHY-UHFFFAOYSA-N
;
UUAOWKSAEYOOIY-UHFFFAOYSA-N
;
UGWGOOAEFJICES-UHFFFAOYSA-N
;
MTXGVGJDJNQPCL-UHFFFAOYSA-N
;
LYCJWVRLAGIQEB-UHFFFAOYSA-N
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
7.
6-Oxooxazolidine-quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFR
作者:
Jiaan Shao
;
En Chen
;
Ke Shu
;
Wenteng Chen
;
wentengchen@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Guolin Zhang
;
guolinzhang@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Yongping Yu
;
yyu@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
Drug resistance
;
Noncovalent EGFR inhibitors
;
Oxooxazolidine
;
Quinazoline
;
Hybrids
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
8.
Nanoparticle type effects on flexural, interfacial and vibration properties of GFRE composites
作者:
U.A. Khashaba
;
1
;
khashabu@zu.edu.eg" class="auth_mail" title="E-mail the corresponding author
;
khashabu@hotmail.com" class="auth_mail" title="E-mail the corresponding author
Author Vitae
关键词:
Flexural properties
;
GFRE composites
;
Interfacial bonding
;
Nanoparticles
;
Non-destructive vibration technique
刊名:Chinese Journal of Aeronautics
出版年:2016
9.
Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines
作者:
Haiqing Yu
a
;
1
;
Yanxia Li
b
;
1
;
Yang Ge
a
;
Zhendong Song
a
;
Changyuan Wang
a
;
Shanshan Huang
a
;
Yue Jin
a
;
Xu Han
a
;
Yuhong Zhen
a
;
Kexin Liu
a
;
kexinliu@dlmedu.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Youwen Zhou
c
;
youwen.zhou@ubc.ca" class="auth_mail" title="E-mail the corresponding author
;
Xiaodong Ma
a
;
xiaodong.ma@139.com" class="auth_mail" title="E-mail the corresponding author
关键词:
NSCLC
;
EGFR
;
T790M
;
Quinazoline
;
Adamantyl
刊名:European Journal of Medicinal Chemistry
出版年:2016
10.
Case report: Durable response to afatinib in a patient with lung cancer harboring two uncommon mutations of EGFR and a KRAS mutation
作者:
Junko Tanizaki
a
;
Eri Banno
b
;
Yosuke Togashi
b
;
c
;
Hidetoshi Hayashi
a
;
hayashi_h@dotd.med.kindai.ac.jp" class="auth_mail" title="E-mail the corresponding author
;
Kazuko Sakai
b
;
Masayuki Takeda
a
;
Hiroyasu Kaneda
a
;
d
;
Kazuto Nishio
b
;
Kazuhiko Nakagawa
a
关键词:
EGFR mutation
;
KRAS mutation
;
Afatinib
;
Non&ndash
;
small cell lung cancer
;
Tyrosine kinase inhibitor
刊名:Lung Cancer
出版年:2016
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