搜索页_+GPR40

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

常用资源

在“Elsevier电子期刊”中，命中：95条，耗时：小于0.01 秒

1.The role of polyunsaturated fatty acids and GPR40 receptor in brain

作者：Muhammad Zahid Khan ; Ling He ; ^{hexyz@163.com} ; ^{heling92@hotmail.com}

关键词：Polyunsaturated fatty acids ; GPR40 receptor ; Neurodegenerative diseases ; Docosahexaenoic acid ; Arachidonic acid

刊名：Neuropharmacology

出版年：2017

2.Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835

作者：Mikhail Krasavin^a ; ^{m.krasavin@spbu.ru} ; Alexey Lukin^b ; Daria Bagnyukova^b ; Nikolay Zhurilo^b ; Aleksei Golovanov^b ; Sergey Zozulya^c ; ^d ; Ihor Zahanich^c ; Daniel Moore^e ; Irina G. Tikhonova^e

关键词：Drug discovery ; FFA1 agonists ; Antidiabetic agents ; Spirocyclic motifs ; Hydrophobic interactions ; π&minus ; π stacking

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior

作者：Fuka Aizawa^a ; Takashi Nishinaka^a ; Takuya Yamashita^b ; Kazuo Nakamoto^a ; Takashi Kurihara^c ; Akira Hirasawa^d ; Fumiyo Kasuya^b ; Atsuro Miyata^c ; Shogo Tokuyama^a ; ^{stoku@pharm.kobegakuin.ac.jp}

关键词：GPR40/FFAR1 ; Free fatty acid ; Anxiety ; Sucrose preference ; Noradrenaline

刊名：Journal of Pharmacological Sciences

出版年：2016

4.GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space

作者：Cheng Chen^a ; ^b ; He Li^a ; Ya-Qiu Long^a ; ^{yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：GPR40 ; G protein-coupled receptor 40 ; FFA1 ; free fatty acid receptor 1 ; PK ; pharmacokinetic ; GSIS ; glucose-stimulated insulin secretion ; T2DM ; type 2 diabetes mellitus ; IDF ; International Diabetes Federation ; GLP-1 ; glucagon-like peptide1 ; GIP ; gastric inhibitory polypeptide ; DPP4 ; dipeptidyl peptidase-4 ; LA ; linoleic acid ; DHA ; docosahexaenoic acid ; IP3 ; inositol-triphosphate 3 ; DAG ; diacylglycerol ; PA ; palmitic acid ; OA ; oleic acid ; MOE ; molecular operating environment ; CNS ; central nervous sy

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells

作者：Kaori Fukushima^a ; Kaede Takahashi^a ; Nobuyuki Fukushima^b ; Kanya Honoki^c ; Toshifumi Tsujiuchi^a ; ^{ttujiuch@life.kindai.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：GPR120 ; GPR40 ; Cell motility ; TPA ; Melanoma cells

刊名：Biochemical and Biophysical Research Communications

出版年：2016

6.Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism

作者：Carlos Puebla^a ; ^{capuebla@uc.cl" class="auth_mail" title="E-mail the corresponding author} ; Bruno A. Cisterna^a ; ^b ; Daniela P. Salas^a ; Fernando Delgado-Ló ; pez^c ; Paul D. Lampe^d ; Juan C. Sá ; ez^a ; ^b ; ^{jsaez@bio.puc.cl" class="auth_mail" title="E-mail the corresponding author}

关键词：Cx ; connexin ; DCFS ; divalent cation-free solution ; Etd+ ; ; ethidium ; FFA ; free fatty acid ; GPCR ; G-protein coupled receptor ; GPR40 ; G-protein receptor 40 ; HC ; hemichannel ; LA ; linoleic acid

刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids

出版年：2016

7.Discovery of the imidazole-derived GPR40 agonist AM-3189

作者：Zhihua Ma^a ; ; Daniel C.-H. Lin^b ; Rajiv Sharma^a ; Jinqian Liu^a ; Liusheng Zhu^a ; An-Rong Li^a ; Todd Kohn^a ; Yingcai Wang^a ; Jiwen (Jim) Liu^a ; Michael D. Bartberger^a ; Julio C. Medina^a ; Run Zhuang^b ; Frank Li^b ; Jane Zhang^b ; Jian Luo^b ; Simon Wong^c ; George R. Tonn^c ; Jonathan B. Houze^a

关键词：GPR40 ; FFAR1 ; GPCR ; Agonist ; Type II diabetes ; Insulin secretagogue ; AMG 837 ; AM-3189

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.GPR40 receptor activation leads to CREB phosphorylation and improves cognitive performance in an Alzheimer’s disease mouse model

作者：Muhammad Zahid Khan¹ ; Xuxu Zhuang¹ ; Ling He ; ^{heling92@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer&rsquo ; s disease ; GPR40 receptor ; cAMP response element binding protein ; Neurotropic factors ; Behavioral tests ; Spatial learning and memory

刊名：Neurobiology of Learning and Memory

出版年：2016

9.Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold

作者：Mikhail Krasavin^a ; ^{m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author} ; Alexey Lukin^b ; Nikolay Zhurilo^b ; Alexey Kovalenko^b ; Ihor Zahanich^c ; Sergey Zozulya^c ; ^d ; Daniel Moore^e ; Irina G. Tikhonova^e

关键词：GPR40 ; Free fatty acid receptor 1 ; FFA1 agonists ; Bioisosteric replacement ; Total polar surface area ; c ; Log P ; Metabolic stability ; Aqueous solubility

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Synthesis and biological evaluation of GPR40/FFAR1 agonists containing 3,5-dimethylisoxazole

作者：Lingyun Yang^a ; ^{yanglingyun130@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jian Zhang^a ; Lianghui Si^a ; Li Han^a ; Bo Zhang^a ; Hui Ma^a ; Junhao Xing^a ; Leilei Zhao^a ; Jinpei Zhou^b ; Huibin Zhang^a ; ^c ; ^{zhanghb80@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Diabetes ; GPR40 agonist ; 3 ; 5-Dimethylisoxazole ; Oral glucose tolerance test

刊名：European Journal of Medicinal Chemistry

出版年：2016

按检索点细分(95)

题名(56)

关键词(59)

文摘(85)

按出版年细分(95)

2027年及以后(3)

2017年(2)

2016年(18)

2015年(4)

2013年(8)

2012年(7)

2011年(11)

2010年(10)

2009年(4)

2008年(5)

2007年(7)

2006年(1)

2005年(5)

2004年(1)

2003年(3)

2000年及以前(6)