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CNKI学位论文(42)
知网期刊论文(65)
在“
Elsevier电子期刊
”中,
命中:
40
条,耗时:小于0.01 秒
在所有数据库中总计命中:
107
条
1.
Polar aromatic periphery increases
agonist
potency of spirocyclic free fatty acid receptor (
GPR40
)
agonist
s inspired by LY2881835
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru
;
Alexey Lukin
b
;
Daria Bagnyukova
b
;
Nikolay Zhurilo
b
;
Aleksei Golovanov
b
;
Sergey Zozulya
c
;
d
;
Ihor Zahanich
c
;
Daniel Moore
e
;
Irina G. Tikhonova
e
关键词:
Drug discovery
;
FFA1
agonist
s
;
Antidiabetic agents
;
Spirocyclic motifs
;
Hydrophobic interactions
;
π&minus
;
π stacking
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Novel free fatty acid receptor 1 (
GPR40
)
agonist
s based on 1,3,4-thiadiazole-2-carboxamide scaffold
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author
;
Alexey Lukin
b
;
Nikolay Zhurilo
b
;
Alexey Kovalenko
b
;
Ihor Zahanich
c
;
Sergey Zozulya
c
;
d
;
Daniel Moore
e
;
Irina G. Tikhonova
e
关键词:
GPR40
;
Free fatty acid receptor 1
;
FFA1
agonist
s
;
Bioisosteric replacement
;
Total polar surface area
;
c
;
Log
P ;
Metabolic stability
;
Aqueous solubility
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
3.
Discovery of the imidazole-derived
GPR40
agonist
AM-3189
作者:
Zhihua Ma
a
;
;
Daniel C.-H. Lin
b
;
Rajiv Sharma
a
;
Jinqian Liu
a
;
Liusheng Zhu
a
;
An-Rong Li
a
;
Todd Kohn
a
;
Yingcai Wang
a
;
Jiwen (Jim) Liu
a
;
Michael D. Bartberger
a
;
Julio C. Medina
a
;
Run Zhuang
b
;
Frank Li
b
;
Jane Zhang
b
;
Jian Luo
b
;
Simon Wong
c
;
George R. Tonn
c
;
Jonathan B. Houze
a
关键词:
GPR40
;
FFAR1
;
GPCR
;
Agonist
;
Type II diabetes
;
Insulin secretagogue
;
AMG 837
;
AM-3189
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
4.
Synthesis and biological evaluation of
GPR40
/FFAR1
agonist
s containing 3,5-dimethylisoxazole
作者:
Lingyun Yang
a
;
yanglingyun130@163.com" class="auth_mail" title="E-mail the corresponding author
;
Jian Zhang
a
;
Lianghui Si
a
;
Li Han
a
;
Bo Zhang
a
;
Hui Ma
a
;
Junhao Xing
a
;
Leilei Zhao
a
;
Jinpei Zhou
b
;
Huibin Zhang
a
;
c
;
zhanghb80@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Diabetes
;
GPR40
agonist
;
3
;
5-Dimethylisoxazole
;
Oral glucose tolerance test
刊名:European Journal of Medicinal Chemistry
出版年:2016
5.
Free fatty acid receptor 1 (
GPR40
)
agonist
s containing spirocyclic periphery inspired by LY2881835
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author
;
Alexey Lukin
b
;
Daria Bagnyukova
b
;
Nikolay Zhurilo
b
;
Ihor Zahanich
c
;
Sergey Zozulya
c
;
d
;
Jouni Ihalainen
e
;
Markus M. Forsberg
e
;
Marko Lehtonen
e
;
Jarkko Rautio
e
;
Daniel Moore
f
;
Irina G. Tikhonova
f
关键词:
GPCR
;
GPR40
;
Free fatty acid receptor 1
;
FFA1
agonist
s
;
Type 2 diabetes mellitus
;
Prins reaction
;
Spirocyclic motifs
;
Metabolic stability
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
6.
GPR40
agonist
s for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
作者:
Cheng Chen
a
;
b
;
He Li
a
;
Ya-Qiu Long
a
;
yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
GPR40
;
G protein-coupled receptor 40
;
FFA1
;
free fatty acid receptor 1
;
PK
;
pharmacokinetic
;
GSIS
;
glucose-stimulated insulin secretion
;
T2DM
;
type 2 diabetes mellitus
;
IDF
;
International Diabetes Federation
;
GLP-1
;
glucagon-like peptide1
;
GIP
;
gastric inhibitory polypeptide
;
DPP4
;
dipeptidyl peptidase-4
;
LA
;
linoleic acid
;
DHA
;
docosahexaenoic acid
;
IP3
;
inositol-triphosphate 3
;
DAG
;
diacylglycerol
;
PA
;
palmitic acid
;
OA
;
oleic acid
;
MOE
;
molecular operating environment
;
CNS
;
central nervous sy
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
7.
Discovery of novel free fatty acid receptor 1
agonist
s bearing triazole core via click chemistry
作者:
Zheng Li
a
;
Jianyong Yang
a
;
Xuekun Wang
a
;
Huilan Li
a
;
Chunxia Liu
a
;
Nasi Wang
a
;
Wenlong Huang
a
;
b
;
ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author
;
Hai Qian
a
;
b
;
qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
FFA1
agonist
;
GPR40
;
Triazole core
;
Click chemistry
;
Type 2 diabetes
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
8.
Design, synthesis and evaluation of potent G-protein coupled receptor 40
agonist
s
作者:
Jing Huang
a
;
1
;
Bin Guo
b
;
1
;
Wen-Jing Chu
b
;
Xin Xie
c
;
Yu-She Yang
b
;
ysyang@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
;
Xian-Li Zhou
a
;
xxbiochem@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
GPR40
;
Anti-diabetic
;
Agonist
;
Phenylpropionic acid derivative
刊名:Chinese Chemical Letters
出版年:2016
9.
Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1
agonist
s for the treatment of type 2 diabetes
作者:
Zheng Li
a
;
Miaobo Pan
a
;
Xin Su
a
;
Yuxuan Dai
a
;
Mian Fu
a
;
Xingguang Cai
a
;
Wei Shi
a
;
Wenlong Huang
a
;
b
;
ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author
;
Hai Qian
a
;
b
;
qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
FFA1
agonist
;
GPR40
;
Ligand efficiency
;
Type 2 diabetes
;
Pyrrole
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
10.
Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1
agonist
s for the treatment of type 2 diabetes
作者:
Zheng Li
a
;
Qianqian Qiu
a
;
Xue Xu
b
;
Xuekun Wang
a
;
Lei Jiao
a
;
Xin Su
a
;
Miaobo Pan
a
;
Wenlong Huang
a
;
c
;
ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author
;
Hai Qian
a
;
c
;
qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
FFA1
agonist
;
GPR40
;
Liver toxicity
;
Type 2 diabetes
;
Heteroaromatics
;
Dihedral angle
刊名:European Journal of Medicinal Chemistry
出版年:2016
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