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CNKI会议论文(2)
CNKI学位论文(82)
知网期刊论文(123)
在“
Elsevier电子期刊
”中,
命中:
75
条,耗时:0.0279607 秒
在所有数据库中总计命中:
207
条
1.
The role of polyunsaturated fatty acids and
GPR40
receptor
in brain
作者:
Muhammad Zahid Khan
;
Ling He
;
hexyz@163.com
;
heling92@hotmail.com
关键词:
Polyunsaturated fatty acids
;
GPR40
receptor
;
Neurodegenerative diseases
;
Docosahexaenoic acid
;
Arachidonic acid
刊名:Neuropharmacology
出版年:2017
2.
Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid
receptor
(
GPR40
) agonists inspired by LY2881835
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru
;
Alexey Lukin
b
;
Daria Bagnyukova
b
;
Nikolay Zhurilo
b
;
Aleksei Golovanov
b
;
Sergey Zozulya
c
;
d
;
Ihor Zahanich
c
;
Daniel Moore
e
;
Irina G. Tikhonova
e
关键词:
Drug discovery
;
FFA1 agonists
;
Antidiabetic agents
;
Spirocyclic motifs
;
Hydrophobic interactions
;
π&minus
;
π stacking
刊名:European Journal of Medicinal Chemistry
出版年:2017
3.
Novel free fatty acid
receptor
1 (
GPR40
) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author
;
Alexey Lukin
b
;
Nikolay Zhurilo
b
;
Alexey Kovalenko
b
;
Ihor Zahanich
c
;
Sergey Zozulya
c
;
d
;
Daniel Moore
e
;
Irina G. Tikhonova
e
关键词:
GPR40
;
Free fatty acid
receptor
1
;
FFA1 agonists
;
Bioisosteric replacement
;
Total polar surface area
;
c
;
Log
P ;
Metabolic stability
;
Aqueous solubility
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
4.
GPR40
receptor
activation leads to CREB phosphorylation and improves cognitive performance in an Alzheimer’s disease mouse model
作者:
Muhammad Zahid Khan
1
;
Xuxu Zhuang
1
;
Ling He
;
heling92@hotmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Alzheimer&rsquo
;
s disease
;
GPR40
receptor
;
cAMP response element binding protein
;
Neurotropic factors
;
Behavioral tests
;
Spatial learning and memory
刊名:Neurobiology of Learning and Memory
出版年:2016
5.
Free fatty acid
receptor
1 (
GPR40
) agonists containing spirocyclic periphery inspired by LY2881835
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author
;
Alexey Lukin
b
;
Daria Bagnyukova
b
;
Nikolay Zhurilo
b
;
Ihor Zahanich
c
;
Sergey Zozulya
c
;
d
;
Jouni Ihalainen
e
;
Markus M. Forsberg
e
;
Marko Lehtonen
e
;
Jarkko Rautio
e
;
Daniel Moore
f
;
Irina G. Tikhonova
f
关键词:
GPCR
;
GPR40
;
Free fatty acid
receptor
1
;
FFA1 agonists
;
Type 2 diabetes mellitus
;
Prins reaction
;
Spirocyclic motifs
;
Metabolic stability
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
6.
Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a
GPR40
- and Akt-dependent mechanism
作者:
Carlos Puebla
a
;
capuebla@uc.cl" class="auth_mail" title="E-mail the corresponding author
;
Bruno A. Cisterna
a
;
b
;
Daniela P. Salas
a
;
Fernando Delgado-Ló
;
pez
c
;
Paul D. Lampe
d
;
Juan C. Sá
;
ez
a
;
b
;
jsaez@bio.puc.cl" class="auth_mail" title="E-mail the corresponding author
关键词:
Cx
;
connexin
;
DCFS
;
divalent cation-free solution
;
Etd+
;
;
ethidium
;
FFA
;
free fatty acid
;
GPCR
;
G-protein coupled
receptor
;
GPR40
;
G-protein
receptor
40
;
HC
;
hemichannel
;
LA
;
linoleic acid
刊名:Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
出版年:2016
7.
GPR40
agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
作者:
Cheng Chen
a
;
b
;
He Li
a
;
Ya-Qiu Long
a
;
yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
GPR40
;
G protein-coupled
receptor
40
;
FFA1
;
free fatty acid
receptor
1
;
PK
;
pharmacokinetic
;
GSIS
;
glucose-stimulated insulin secretion
;
T2DM
;
type 2 diabetes mellitus
;
IDF
;
International Diabetes Federation
;
GLP-1
;
glucagon-like peptide1
;
GIP
;
gastric inhibitory polypeptide
;
DPP4
;
dipeptidyl peptidase-4
;
LA
;
linoleic acid
;
DHA
;
docosahexaenoic acid
;
IP3
;
inositol-triphosphate 3
;
DAG
;
diacylglycerol
;
PA
;
palmitic acid
;
OA
;
oleic acid
;
MOE
;
molecular operating environment
;
CNS
;
central nervous sy
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
8.
PPARγ signaling and emerging opportunities for improved therapeutics
作者:
Shuibang Wang
;
swang@cc.nih.gov" class="auth_mail" title="E-mail the corresponding author
;
Edward J. Dougherty
;
Robert L. Danner
;
rdanner@nih.gov" class="auth_mail" title="E-mail the corresponding author
关键词:
PPARγ
;
peroxisome proliferator-activated
receptor
gamma
;
TZD
;
thiazolidinedione
;
T2DM
;
type 2 diabetes mellitus
;
RGZ
;
rosiglitazone
;
15d-PGJ2
;
15-deoxy-D12
;
14-prostanglandin J2
;
PGC-1α
;
PPARγ co-activator-1α
;
RXR
;
retinoid X
receptor
;
PPRE
;
peroxisome proliferator response element
;
NO
;
nitric oxide
;
EP300
;
E1A binding protein p300
;
PTM
;
post-translational modification
;
BAT
;
brown adipose tissue
;
SAT
;
subcutaneous white adipose tissue
;
VAT
;
visceral white adipose tissue
;
GPR40
;
G protein-coupled
刊名:Pharmacological Research
出版年:2016
9.
GPR40
/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior
作者:
Fuka Aizawa
a
;
Takashi Nishinaka
a
;
Takuya Yamashita
b
;
Kazuo Nakamoto
a
;
Takashi Kurihara
c
;
Akira Hirasawa
d
;
Fumiyo Kasuya
b
;
Atsuro Miyata
c
;
Shogo Tokuyama
a
;
stoku@pharm.kobegakuin.ac.jp
关键词:
GPR40
/FFAR1
;
Free fatty acid
;
Anxiety
;
Sucrose preference
;
Noradrenaline
刊名:Journal of Pharmacological Sciences
出版年:2016
10.
Discovery of novel free fatty acid
receptor
1 agonists bearing triazole core via click chemistry
作者:
Zheng Li
a
;
Jianyong Yang
a
;
Xuekun Wang
a
;
Huilan Li
a
;
Chunxia Liu
a
;
Nasi Wang
a
;
Wenlong Huang
a
;
b
;
ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author
;
Hai Qian
a
;
b
;
qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
FFA1 agonist
;
GPR40
;
Triazole core
;
Click chemistry
;
Type 2 diabetes
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
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