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在“Elsevier电子期刊”中，命中：27条，耗时：小于0.01 秒

1.Effective G-protein coupling of Y2 receptors along axonal fiber tracts and its relevance for epilepsy

作者：Elisabeth Dum¹ ; ^{dum.elisabeth@gmail.com} ; Sabine Fü ; rtinger² ; ^{sabine.fuertinger@gmx.at} ; Elisabeth Gasser ; Anneliese Bukovac ; Meinrad Drexel ; Ramon Tasan ; Gü ; nther Sperk ; ^{guenther.sperk@i-med.ac.at}

关键词：NPY ; Y2 receptors ; Schaffer collaterals ; Stria terminalis ; GTPγS ; G-protein coupling ; Kainic acid ; Epilepsy

刊名：Neuropeptides

出版年：2017

2.Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt¹]N/OFQ(1-13)

作者：Maria Camilla Cerlesi^a ; Huiping Ding^b ; Mark F. Bird^c ; Norikazu Kiguchi^b ; Federica Ferrari^a ; Davide Malfacini^a ; Anna Rizzi^a ; Chiara Ruzza^a ; David G. Lambert^c ; Mei-Chuan Ko^b ; Girolamo Calo^a ; ; Remo Guerrini^d

关键词：PWT2-[Dmt1]N/OFQ(1&ndash ; 13) ; NOP and opioid receptors ; Receptor binding ; Stimulation of [35S]GTPγS binding ; Calcium mobilization ; Monkey spinal analgesia

刊名：European Journal of Pharmacology

出版年：2017

3.In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator

作者：Alessandra Porcu^a ; Carla Lobina^b ; Daniela Giunta^c ; Maurizio Solinas^c ; Claudia Mugnaini^d ; M. Paola Castelli^a ; ^{castelli@unica.it" class="auth_mail" title="E-mail the corresponding author}

关键词：GABAB receptors ; Positive allosteric modulator ; GTPγS binding ; Baclofen-induced sedation/hypnosis

刊名：European Journal of Pharmacology

出版年：2016

4.In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations

作者：Federica Ferrari^a ; Maria Camilla Cerlesi^a ; Davide Malfacini^a ; Laila Asth^b ; Elaine C. Gavioli^b ; Blair V. Journigan^c ; Uma Gayathri Kamakolanu^c ; Michael E. Meyer^c ; Dennis Yasuda^c ; Willma E. Polgar^d ; Anna Rizzi^a ; Remo Guerrini^e ; Chiara Ruzza^a ; Nurulain T. Zaveri^c ; Girolamo Calo^a ; ^{g.calo@unife.it}

关键词：NOP and classical opioid receptors ; Bioluminescence resonance energy transfer ; Calcium mobilization and mouse colon vas deferens and assays ; Receptor and [35S]GTPγS binding

刊名：European Journal of Pharmacology

出版年：2016

5.Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres

作者：Chad M. Kormos ; Moses G. Gichinga ; Scott P. Runyon ; James B. Thomas ; S. Wayne Mascarella ; Ann M. Decker ; Herná ; n A. Navarro ; F. Ivy Carroll ; ^{fic@rti.org" class="auth_mail" title="E-mail the corresponding author}

关键词：[35S]GTPγS ; sulfur-35 guanosine-5&prime ; -O-(3-thio)triphosphate ; DAMGO ; [D-Ala2 ; MePhe4 ; Gly-ol5]enkephalin ; DPDPE ; [D-Pen2 ; D-Pen5]enkephalin ; U69 ; 593 ; (5α ; 7α ; 8β)-(&minus ; )-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4 ; 5]dec-8-yl]benzeneacetamide

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Characterization of kappa opioid receptor mediated, dynorphin-stimulated [³⁵S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting

作者：Lei Zhou^a ; ^b ; Edward L. Stahl^a ; ^b ; Kimberly M. Lovell^a ; ^b ; Kevin J. Frankowski^c ; Thomas E. Prisinzano^c ; Jeffrey Aubé ; ^c ; Laura M. Bohn^a ; ^b ; ^{lbohn@scripps.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Dynorphin ; Kappa opioid receptor ; [35S]GTPγS binding ; Mouse striatum ; Selectivity ; Drug discovery ; KOR antagonist

刊名：Neuropharmacology

出版年：2015

7.Mu-Opioid (MOP) receptor mediated G-protein signaling is impaired in specific brain regions in a rat model of schizophrenia

作者：Edina Szűcs^a ; Alexandra Bü ; ki^b ; Gabriella Ké ; kesi^b ; Gyö ; ngyi Horvá ; th^b ; Sá ; ndor Benyhe^a ; ^{benyhe@brc.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：G-protein stimulation ; [35S]GTPγS binding ; Brain membranes ; Opioid receptors ; DAMGO ; Schizophrenia animal model

刊名：Neuroscience Letters

出版年：2016

8.Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia

作者：Edina Szűcs^a ; Szabolcs Dvorá ; cskó ; ^a ; Csaba Tö ; mbö ; ly^a ; Alexandra Bü ; ki^b ; Gabriella Ké ; kesi^b ; Gyö ; ngyi Horvá ; th^b ; Sá ; ndor Benyhe^a ; ^{benyhe@brc.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：G-protein activation ; [35S]GTPγS binding ; Radioligand binding ; Cannabinoid receptors ; WIN-55 ; 212-2 mesylate ; Schizophrenia animal model

刊名：Neuroscience Letters

出版年：2016

9.Novel multifunctional dopamine D₂/D₃ receptors agonists with potential neuroprotection and anti-alpha synuclein protein aggregation properties

作者：Dan Luo^a ; Horrick Sharma^a ; Deepthi Yedlapudi^a ; Tamara Antonio^b ; Maarten E.A. Reith^b ; Aloke K. Dutta^a ; ^{adutta@wayne.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：TPP ; triphenylphosphine ; NaHMDS ; sodium bis(trimethylsilyl)amide ; DIBALH ; diisobutylaluminium hydride ; TBS ; tert-butyldimethylsilyl ; TBDMSCl ; tert-butyl(chloro)dimethylsilane ; PCC ; pyridinium chlorochromate ; TBAF ; tetra-n-butylammonium fluoride ; HMDS ; hexamethyldisilazane ; n-BuLi ; n-butyllithium ; 6-OHDA ; 6-hydroxydopamine ; GTPγS ; guanosine 5&prime ; -O-[γ-thio]-triphosphate ; 5-OH-DPAT ; 5-hydroxy-2-(dipropylamino)-tetralin ; HEK ; human embryonic kidney ; CHO ; Chinese hamster ovary ; PD ; Parkinson&rsqu

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data

作者：Lisa A. Stott^a ; David A. Hall^b ; Nicholas D. Holliday^a ; ^{nicholas.holliday@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：CRC ; concentration response curve ; EC50 ; effective agonist concentration for 50% maximum response ; Emax ; maximum system response ; GPCR ; G protein coupled receptor ; D2R ; dopamine D2 receptor ; GTPγS ; guanosine 5&prime ; -O-[γ-thio]triphosphate ; KA ; agonist equilibrium dissociation constant ; KE ; concentration of agonist&ndash ; receptor complex which produces a half maximal effect ; MAPK ; mitogen activated protein kinase ; RAi ; relative intrinsic activity ratio ; Rmax ; maximum agonist response ; RT ; total

刊名：Biochemical Pharmacology

出版年：2016

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