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在“Elsevier电子期刊”中，命中：69条，耗时：0.0139938 秒

在所有数据库中总计命中：317条

1.Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B

作者：Marko Jukič^a ; Janez Ila&scaron ; ^a ; Matjaž Brvar^b ; Danijel Kikelj^a ; Jožko Cesar^a ; Marko Anderluh^a ; ^{marko.anderluh@ffa.uni-lj.si}

关键词：Antibiotics ; Antibacterials ; Inhibitor ; DNA gyrase B ; ATP binding site ; Pyrrole-2-carboxamides ; Structure-based drug design ; Ligand-based drug design

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors

作者：Tihomir Toma&scaron ; ič^a ; ^{tihomir.tomasic@ffa.uni-lj.si} ; Matic Mirt^a ; Michaela Barančoková ; ^a ; Janez Ila&scaron ; ^a ; Nace Zidar^a ; Pä ; ivi Tammela^b ; Danijel Kikelj^a

关键词：Antibacterial ; DNA gyrase ; Docking ; Inhibitor ; Thiazole

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Antimicrobial activity of novel 4H-4-oxoquinolizine compounds against extensively drug-resistant Acinetobacter baumannii strains

作者：Seok Hyeon Na^a ; Hyejin Jeon^a ; Yoo Jeong Kim^a ; Hyo Il Kwon^a ; Gati Noble Selasi^a ; Asiimwe Nicholas^a ; Chang-Soo Yun^b ; Sang Ho Lee^b ; Je Chul Lee^a ; ^{leejc@knu.ac.kr}

关键词：4H-4-oxoquinolizine ; Fluoroquinolone ; Antimicrobial resistance ; DNA gyrase inhibitor ; Chemical compound

刊名：International Journal of Antimicrobial Agents

出版年：2017

4.New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase

作者：Nace Zidar^a ; ^{nace.zidar@ffa.uni-lj.si" class="auth_mail" title="E-mail the corresponding author} ; Tihomir Toma&scaron ; ič^a ; Helena Macut^a ; Anja Sirc^a ; Matjaž Brvar^b ; Sofia Montalvã ; o^c ; Pä ; ivi Tammela^c ; Janez Ila&scaron ; ^a ; Danijel Kikelj^a

关键词：Antibacterial ; 4 ; 5-Dibromopyrrole ; DNA gyrase ; GyrB ; Inhibitor ; Topoisomerase IV

刊名：European Journal of Medicinal Chemistry

出版年：2016

5.Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors

作者：Variam Ullas Jeankumar¹ ; Rudraraju Srilakshmi Reshma¹ ; Rahul Vats ; Renuka Janupally ; Shalini Saxena ; Perumal Yogeeswari ; Dharmarajan Sriram ; ^{dsriram@hyderabad.bits-pilani.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Medium throughput virtual screening ; Mycobacterium tuberculosis ; DNA gyrase ; Differential scanning fluorimetry

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB

作者：Michael F. Mesleh^a ; ; Jason B. Cross^a ; Jing Zhang^a ; Jan Kahmann^b ; Ole A. Andersen^c ; John Barker^c ; Robert K. Cheng^c ; Brunella Felicetti^c ; Michael Wood^c ; Andrea T. Hadfield^c ; Christoph Scheich^b ; Terence I. Moy^a ; Qingyi Yang^a ; Joseph Shotwell^a ; Kien Nguyen^a ; Blaise Lippa^a ; Roland Dolle^a ; M. Dominic Ryan^a

关键词：DNA gyrase ; GyrB ; Fragment-based screening ; NMR ; Structure-based design

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Discovery and development of kibdelomycin, a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase

作者：Sheo B. Singh ^{Sheo.Singh.215@gmail.com}

关键词：Antibacterials ; Natural products ; Gyrase inhibitor ; DNA synthesis inhibitor ; Novel target binding ; Broad-spectrum ; Clostridium difficile

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors

作者：Karyakulam Andrews Bobesh^a ; ^&dagger ; ; Janupally Renuka^a ; ^&dagger ; ; Rudraraju Reshma Srilakshmi^a ; Swapna Yellanki^b ; ^c ; Pushkar Kulkarni^b ; ^c ; Perumal Yogeeswari^a ; Dharmarajan Sriram^a ; ^{dsriram@hyderabad.bits-pilani.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：DNA gyrase ; Topoisomerase ; Tuberculosis ; 1 ; 5-Naphthyridin-2(1H)-one ; zERG toxicity

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor

作者：Yan Li ; Yun Xuan Wong ; Zhi Ying Poh ; Ying Lei Wong ; Michelle Yueqi Lee ; Hui Qi Ng ; Boping Liu ; Alvin W. Hung ; Joseph Cherian ; Jeffrey Hill ; Thomas H. Keller ; CongBao Kang ; ^{cbkang@etc.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author}

关键词：NMR ; Drug discovery ; Topoisomerase ; Gyrase B ; Structure-based drug design

刊名：FEBS Letters

出版年：2015

10.Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action

作者：Kunal Patel^a ; Chetna Tyagi^b ; Sukriti Goyal^b ; Salma Jamal^b ; Divya Wahi^c ; Ritu Jain^c ; Navneeta Bharadvaja^a ; Abhinav Grover^c ; ^{abhinavgr@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{agrover@mail.jnu.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：HTVS ; high throughput virtual screening ; CA ; chebulinic acid ; XP ; extra precision ; MDR-TB ; multiple-drug resistant tuberculosis ; XDR-TB ; extensively-drug resistant tuberculosis ; QRDR ; quinolone resistance determining region ; CTD ; C-terminal domain ; PSVS ; protein structure validation suite ; MD ; molecular dynamics

刊名：Computational Biology and Chemistry

出版年：2015

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